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D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
18435
World Ranking
5954
National Ranking
427

Overview

Thomas Höfer is affiliated with the German Cancer Research Center in Germany. Their research primarily spans the fields of biochemistry, genetics and molecular biology, medicine, and immunology and microbiology.

Their work engages deeply with subfields including immunology, molecular biology, oncology, genetics, and cancer research. The main topics of Höfer's research cover single-cell and spatial transcriptomics, immune cell function and interaction, T-cell and B-cell immunology, cancer genomics and diagnostics, hematopoietic stem cell transplantation, cancer immunotherapy and biomarkers, and immunotherapy and immune responses.

Höfer has contributed extensively to scientific literature, with frequent publications in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Oncology
  • Nature Communications
  • Experimental Hematology
  • Immunity

Selected recent papers illustrate the breadth of their research:

  • Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity (2020, Immunity)
  • Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma (2021, Nature Genetics)
  • MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis (2022, Nature Cancer)
  • Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding (2020, Cell Stem Cell)
  • Asynchronous nuclear cycles in multinucleated Plasmodium falciparum facilitate rapid proliferation (2022, Science Advances)

The scientist frequently collaborates with other researchers, including Verena Körber, Nils B. Becker, Alessandro Greco, Hans-Reimer Rodewald, and Xi Wang.

Best Publications

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

    Katrin Busch;Kay Klapproth;Melania Barile;Michael Flossdorf

  • Telomerase activation by genomic rearrangements in high-risk neuroblastoma

    Martin Peifer;Falk Hertwig;Frederik Roels;Daniel Dreidax

  • Modelling of simple and complex calcium oscillations

    Stefan Schuster;Stefan Schuster;Marko Marhl;Thomas Höfer

  • Disparate Individual Fates Compose Robust CD8+ T Cell Immunity

    Veit R. Buchholz;Michael Flossdorf;Michael Flossdorf;Inge Hensel;Lorenz Kretschmer

  • Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.

    Konstantina Nika;Cristiana Soldani;Mogjiborahman Salek;Wolfgang Paster

  • The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes

    Anna-Barbara Stittrich;Claudia Haftmann;Evridiki Sgouroudis;Anja Andrea Kühl

  • Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12

    Edda G. Schulz;Luca Mariani;Andreas Radbruch;Thomas Höfer

  • Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

    Weike Pei;Thorsten B. Feyerabend;Jens Rössler;Xi Wang

  • Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells

    Patricia Graef;Veit R. Buchholz;Christian Stemberger;Michael Flossdorf;Michael Flossdorf

  • Toward a Refined Definition of Monocyte Subsets

    Loems Ziegler-Heitbrock;Thomas P. J. Hofer

  • Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

    Dorothea Busse;Maurus de la Rosa;Kirstin Hobiger;Kevin Thurley

  • Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

    Ulrike M. Litzenburger;Christiane A. Opitz;Felix Sahm;Felix Sahm;Katharina J. Rauschenbach

  • Control and Plasticity of Intercellular Calcium Waves in Astrocytes: A Modeling Approach

    Thomas Höfer;Laurent Venance;Christian Giaume

  • Multisite protein phosphorylation – from molecular mechanisms to kinetic models

    Carlos Salazar;Thomas Höfer

  • Genome-wide nucleosome positioning during embryonic stem cell development

    Vladimir B Teif;Yevhen Vainshtein;Maïwen Caudron-Herger;Jan-Philipp Mallm

  • Data2Dynamics: A modeling environment tailored to parameter estimation in dynamical systems

    A. Raue;B. Steiert;M. Schelker;C. Kreutz

  • Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis

    Verena Körber;Verena Körber;Jing Yang;Pankaj Barah;Yonghe Wu

  • Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango.

    Alexander Scheffold;Jochen Hühn;Thomas Höfer

  • A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

    Mahima Swamy;Mahima Swamy;Mahima Swamy;Katharina Beck-Garcia;Katharina Beck-Garcia;Esmeralda Beck-Garcia;Esmeralda Beck-Garcia;Frederike A. Hartl

Frequent Co-Authors

Philip K. Maini
Philip K. Maini University of Oxford
Wolfgang W. A. Schamel
Wolfgang W. A. Schamel University of Freiburg
Max Löhning
Max Löhning Charité - University Medicine Berlin
Andreas Radbruch
Andreas Radbruch German Rheumatism Research Centre
Dirk H. Busch
Dirk H. Busch Technical University of Munich
Frank Westermann
Frank Westermann German Cancer Research Center
Matias D. Zurbriggen
Matias D. Zurbriggen Heinrich Heine University Düsseldorf
Michael Brunner
Michael Brunner Heidelberg University
Christoph Rader
Christoph Rader Scripps Research Institute
Roel van Driel
Roel van Driel University of Amsterdam

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