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Matthias Fischer

Matthias Fischer

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
19413
World Ranking
6591
National Ranking
472

Overview

Matthias Fischer is affiliated with the University of Cologne in Germany and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans multiple subfields including Neurology, Molecular Biology, Cancer Research, Genetics, and Oncology.

Their work focuses primarily on topics related to Neuroblastoma Research and Treatments, Cancer, Hypoxia, and Metabolism, Lung Cancer Research Studies, Cancer therapeutics and mechanisms, RNA modifications and cancer, Glioma Diagnosis and Treatment, and Protein Degradation and Inhibitors.

Frequent publication venues for Matthias Fischer include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Scientific Reports
  • Klinische Pädiatrie
  • Cancer Discovery

Notable recent papers illustrate the focus and impact of their research:

  • "The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets," 2021, Cancer Discovery
  • "Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma," 2020, Nature Communications
  • "MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis," 2022, Nature Cancer
  • "Chromothripsis followed by circular recombination drives oncogene amplification in human cancer," 2021, Nature Genetics
  • "Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome," 2021, Nature Communications

Matthias Fischer has collaborated extensively with a number of co-authors, with particularly frequent collaborations including:

  • Christoph Bartenhagen
  • Angelika Eggert
  • Carolina Rosswog
  • Johannes H. Schulte
  • Barbara Hero

This body of work demonstrates a consistent concentration on cancer biology and neuroblastoma, often integrating molecular mechanisms with clinical oncology to address disease progression and therapeutic vulnerabilities.

Best Publications

  • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

    Martin Peifer;Lynnette Fernández-Cuesta;Martin L. Sos;Julie George

  • The Microarray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

    Leming Shi;Gregory Campbell;Wendell D. Jones;Fabien Campagne

  • A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

    Zhenqiang Su;Paweł P. Łabaj;Sheng Li;Jean Thierry-Mieg

  • Telomerase activation by genomic rearrangements in high-risk neuroblastoma

    Martin Peifer;Falk Hertwig;Frederik Roels;Daniel Dreidax

  • Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

    Susanne Walz;Francesca Lorenzin;Jennifer Morton;Katrin E. Wiese

  • Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

    Ina Oehme;Hedwig E. Deubzer;Dennis Wegener;Diana Pickert

  • Comparison of RNA-seq and microarray-based models for clinical endpoint prediction.

    Wenqian Zhang;Ying Yu;Falk Hertwig;Falk Hertwig;Jean Thierry-Mieg

  • Somatic hypermutation in normal and transformed human B cells

    U Klein;T Goossens;M Fischer;H Kanzler

  • Reporting guidelines for human microbiome research: the STORMS checklist

    Chloe Mirzayi;Audrey Renson;Massive Analysis

  • LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

    Jan J Molenaar;Raquel Domingo-Fernández;Marli E Ebus;Sven Lindner

  • Customized Oligonucleotide Microarray Gene Expression–Based Classification of Neuroblastoma Patients Outperforms Current Clinical Risk Stratification

    André Oberthuer;Frank Berthold;Patrick Warnat;Barbara Hero

  • Mutational dynamics between primary and relapse neuroblastomas

    Alexander Schramm;Johannes Köster;Johannes Köster;Yassen Assenov;Kristina Althoff

  • The risk-associated long noncoding RNA NBAT-1 controls neuroblastoma progression by regulating cell proliferation and neuronal differentiation.

    Gaurav Kumar Pandey;Sanhita Mitra;Santhilal Subhash;Falk Hertwig

  • Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

    Markus Brockmann;Evon Poon;Teeara Berry;Anne Carstensen

  • Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study

    Barbara C. Worst;Barbara C. Worst;Cornelis M. van Tilburg;Gnana Prakash Balasubramanian;Petra Fiesel;Petra Fiesel

  • Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas

    Frank Westermann;Daniel Muth;Axel Benner;Tobias Bauer

  • Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma

    Shahab Asgharzadeh;Jill A. Salo;Lingyun Ji;André Oberthuer

  • A mechanistic classification of clinical phenotypes in neuroblastoma

    Sandra Ackermann;Sandra Ackermann;Maria Cartolano;Barbara Hero;Anne Welte;Anne Welte

  • Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma

    Richard P. Koche;Elias Rodriguez-Fos;Konstantin Helmsauer;Martin Burkert;Martin Burkert

  • The Tumor-Associated Antigen PRAME Is Universally Expressed in High-Stage Neuroblastoma and Associated with Poor Outcome

    André Oberthuer;Barbara Hero;Rüdiger Spitz;Frank Berthold

Frequent Co-Authors

Frank Berthold
Frank Berthold University of Cologne
Frank Westermann
Frank Westermann German Cancer Research Center
Johannes H. Schulte
Johannes H. Schulte Charité - University Medicine Berlin
Benedikt Brors
Benedikt Brors German Cancer Research Center
Jo Vandesompele
Jo Vandesompele Ghent University
Leming Shi
Leming Shi Fudan University
Katleen De Preter
Katleen De Preter Ghent University
Roland Eils
Roland Eils Charité - University Medicine Berlin
Manfred Schwab
Manfred Schwab German Cancer Research Center
Pieter Mestdagh
Pieter Mestdagh Ghent University

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