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Molecular Biology

D-Index
85
Citations
32246
World Ranking
844
National Ranking
23

Overview

Rogier Versteeg is affiliated with the University of Amsterdam in the Netherlands and has contributed significantly to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on neuroblastoma and cancer biology, exploring molecular mechanisms, cellular phenotypes, and therapeutic targets.

Their publication record includes influential papers such as:

  • Super enhancers define regulatory subtypes and cell identity in neuroblastoma (2020, Nature Cancer)
  • A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities (2020, Nature Communications)
  • Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes (2022, Nature Cancer)
  • SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry (2023, Nature Communications)
  • DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma (2022, JCI Insight)

Versteeg's main topics of work cover:

  • Neuroblastoma Research and Treatments
  • Cancer, Hypoxia, and Metabolism
  • Protein Degradation and Inhibitors
  • Cancer therapeutics and mechanisms
  • Cell death mechanisms and regulation
  • Ubiquitin and proteasome pathways
  • Immune cells in cancer

The scientist's subfields of study include:

  • Molecular Biology
  • Neurology
  • Cancer Research
  • Immunology
  • Genetics

Versteeg has published predominantly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cancer
  • Nature Communications
  • JCI Insight
  • Proceedings of the National Academy of Sciences

Frequent collaborators in their work include:

  • Jan Köster
  • Johan van Nes
  • Ellen M. Westerhout
  • Linda Schild
  • Marli E. Ebus

Overall, Rogier Versteeg's research portfolio encompasses a multidisciplinary approach bridging molecular biology, cancer research, and immunological perspectives, particularly focused on neuroblastoma mechanisms and treatment strategies.

Best Publications

  • Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

    Marc van de Wetering;Hayley E. Francies;Joshua M. Francis;Joshua M. Francis;Gergana Bounova

  • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

    Dominik Sturm;Hendrik Witt;Hendrik Witt;Volker Hovestadt;Dong Anh Khuong-Quang

  • Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

    Kristian W. Pajtler;Kristian W. Pajtler;Hendrik Witt;Martin Sill;David T.W. Jones

  • The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

    Huib Caron;Barbera van Schaik;Merlijn van der Mee;Frank Baas

  • New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Dominik Sturm;Dominik Sturm;Brent A. Orr;Umut H. Toprak;Volker Hovestadt

  • Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

    Jan J. Molenaar;Jan Koster;Danny A. Zwijnenburg;Peter van Sluis

  • Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

    Tobias Rausch;David T.W. Jones;Marc Zapatka;Adrian M. Stütz

  • Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

    Marcel Kool;Jan Koster;Jens Bunt;Nancy E. Hasselt

  • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

    David T W Jones;Barbara Hutter;Natalie Jäger;Andrey Korshunov;Andrey Korshunov

  • The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

    Javier Muñoz;Daniel E Stange;Arnout G Schepers;Marc van de Wetering

  • Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

    Marcel Kool;David T.W. Jones;Natalie Jäger;Paul A. Northcott

  • Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

    Paul A. Northcott;Catherine Lee;Catherine Lee;Thomas Zichner;Adrian M. Stütz

  • N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis.

    Kathy Boon;Kathy Boon;Huib N. Caron;Ronald Van Asperen;Linda Valentijn

  • Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

    Thomas F Eleveld;Derek A Oldridge;Virginie Bernard;Jan Koster

  • Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

    Pascal D. Johann;Pascal D. Johann;Serap Erkek;Marc Zapatka;Kornelius Kerl

  • Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

    Johannes H. Schulte;Soyoung Lim;Alexander Schramm;Nicolaus Friedrichs

  • Allelic loss of chromosome 1p as a predictor of unfavorable outcome in patients with neuroblastoma.

    H.N. Caron;P. van Sluis;J. de Kraker;J.P.M. Bökkerink

  • Neuroblastoma is composed of two super-enhancer-associated differentiation states

    Tim van Groningen;Jan Koster;Linda J Valentijn;Danny A Zwijnenburg

  • Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

    Volker Hovestadt;David T.W. Jones;Simone Picelli;Wei Wang

  • The Human Transcriptome Map Reveals Extremes in Gene Density, Intron Length, GC Content, and Repeat Pattern for Domains of Highly and Weakly Expressed Genes

    Rogier Versteeg;Barbera D.C. van Schaik;Marinus F. van Batenburg;Marco Roos

Frequent Co-Authors

Jan Koster
Jan Koster University of Amsterdam
Franki Speleman
Franki Speleman Ghent University
Johannes H. Schulte
Johannes H. Schulte Charité - University Medicine Berlin
Katleen De Preter
Katleen De Preter Ghent University
Genevieve Laureys
Genevieve Laureys Ghent University Hospital
Marcel Kool
Marcel Kool German Cancer Research Center
Raymond L. Stallings
Raymond L. Stallings Royal College of Surgeons in Ireland
Jo Vandesompele
Jo Vandesompele Ghent University
Andries Westerveld
Andries Westerveld University of Amsterdam
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center

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