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Biology and Biochemistry

D-Index
79
Citations
36449
World Ranking
4206
National Ranking
100

Overview

Jan Koster is affiliated with the University of Amsterdam in the Netherlands. Their research contributions span primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a total of 168 and 156 publications respectively. Within these broad fields, Koster's work is focused on subfields such as Molecular Biology, Oncology, Neurology, Cancer Research, and Genetics.

Koster's recent publications include multiple papers in high-impact journals that cover a range of topics related to cancer biology and molecular mechanisms. Some notable papers include:

  • Apc-mutant cells act as supercompetitors in intestinal tumour initiation, 2021, Nature
  • The RNA Atlas expands the catalog of human non-coding RNAs, 2021, Nature Biotechnology
  • Super enhancers define regulatory subtypes and cell identity in neuroblastoma, 2020, Nature Cancer
  • Molecular characterization of colorectal cancer related peritoneal metastatic disease, 2022, Nature Communications
  • Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome, 2021, Nature Communications

The topics of Koster's research reflect a focus on cancer types and mechanisms, including neuroblastoma, protein degradation pathways, tumor metabolism, and cancer genomics. Key research topics covered in their work are:

  • Neuroblastoma Research and Treatments
  • Protein Degradation and Inhibitors
  • Cancer, Hypoxia, and Metabolism
  • Cancer-related molecular mechanisms research
  • Glioma Diagnosis and Treatment
  • Pancreatic and Hepatic Oncology Research
  • Cancer Genomics and Diagnostics

Koster frequently publishes in several scientific journals. The most common venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • European Journal of Cancer
  • Nature Communications
  • Cell Reports

Throughout the course of their research career, Koster has collaborated extensively with several researchers. Frequent co-authors include:

  • Jan J. Molenaar
  • Maarten F. Bijlsma
  • Danny A. Zwijnenburg
  • Jan Paul Medema
  • Rogier Versteeg

Koster's work in these areas contributes a comprehensive approach to studying cancer biology, exploring genetic and molecular facets across different types of tumors and oncology research. The scope of their research regarding molecular biology and cancer-related mechanisms aligns with the publication record and collaborative network documented in scientific literature.

Best Publications

  • Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

    Marc van de Wetering;Hayley E. Francies;Joshua M. Francis;Joshua M. Francis;Gergana Bounova

  • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

    Dominik Sturm;Hendrik Witt;Hendrik Witt;Volker Hovestadt;Dong Anh Khuong-Quang

  • The landscape of genomic alterations across childhood cancers

    Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter

  • Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

    Marcel Kool;Andrey Korshunov;Marc Remke;Marc Remke;David T.W. Jones

  • Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

    Kristian W. Pajtler;Kristian W. Pajtler;Hendrik Witt;Martin Sill;David T.W. Jones

  • The whole-genome landscape of medulloblastoma subtypes

    Paul A. Northcott;Paul A. Northcott;Ivo Buchhalter;Ivo Buchhalter;A. Sorana Morrissy;Volker Hovestadt

  • New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

    Dominik Sturm;Dominik Sturm;Brent A. Orr;Umut H. Toprak;Volker Hovestadt

  • Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

    Jan J. Molenaar;Jan Koster;Danny A. Zwijnenburg;Peter van Sluis

  • Dissecting the genomic complexity underlying medulloblastoma

    David T. W. Jones;Natalie Jäger;Marcel Kool;Thomas Zichner

  • Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

    Tobias Rausch;David T.W. Jones;Marc Zapatka;Adrian M. Stütz

  • Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

    Marcel Kool;Jan Koster;Jens Bunt;Nancy E. Hasselt

  • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

    David T W Jones;Barbara Hutter;Natalie Jäger;Andrey Korshunov;Andrey Korshunov

  • RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

    Myron G. Best;Nik Sol;Irsan Kooi;Jihane Tannous

  • The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

    Javier Muñoz;Daniel E Stange;Arnout G Schepers;Marc van de Wetering

  • Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

    Marcel Kool;David T.W. Jones;Natalie Jäger;Paul A. Northcott

  • Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

    Paul A. Northcott;Catherine Lee;Catherine Lee;Thomas Zichner;Adrian M. Stütz

  • Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

    S. C. Mack;H. Witt;R. M. Piro;L. Gu

  • Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

    Thomas F Eleveld;Derek A Oldridge;Virginie Bernard;Jan Koster

  • Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium

    Daniel E. Stange;Daniel E. Stange;Bon-Kyoung Koo;Bon-Kyoung Koo;Meritxell Huch;Greg Sibbel

  • Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

    Pascal D. Johann;Pascal D. Johann;Serap Erkek;Marc Zapatka;Kornelius Kerl

Frequent Co-Authors

Rogier Versteeg
Rogier Versteeg University of Amsterdam
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Marcel Kool
Marcel Kool German Cancer Research Center
Andrey Korshunov
Andrey Korshunov German Cancer Research Center
Katleen De Preter
Katleen De Preter Ghent University
Johannes H. Schulte
Johannes H. Schulte Charité - University Medicine Berlin
Andreas von Deimling
Andreas von Deimling Heidelberg University
David T. W. Jones
David T. W. Jones German Cancer Research Center
Dirk Geerts
Dirk Geerts University of Amsterdam
Paul A. Northcott
Paul A. Northcott St. Jude Children's Research Hospital

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