Jan Koster spends much of his time researching Cancer research, Medulloblastoma, Cancer, Neuroblastoma and Gene expression profiling. His Cancer research research integrates issues from DNA methylation, Mutation, Immunology, Gene silencing and Epigenetics. The study incorporates disciplines such as Bioinformatics, Li–Fraumeni syndrome, Germline, Genomics and PTCH1 in addition to Medulloblastoma.
His Cancer research is multidisciplinary, incorporating perspectives in Microprocessor complex, DGCR8, Germline mutation and Human genetics. His studies deal with areas such as Molecular biology, Regulation of gene expression, Receptor and RNA interference as well as Neuroblastoma. His work in Gene expression profiling tackles topics such as Transcriptome which are related to areas like Cell, SNP, Retrospective cohort study, Meta-analysis and Adult Medulloblastoma.
His main research concerns Cancer research, Neuroblastoma, Cancer, Molecular biology and Cell biology. His research in Cancer research intersects with topics in Cellular differentiation, Gene expression profiling, Mutation, Carcinogenesis and Cell cycle. His Gene expression profiling research includes elements of Medulloblastoma and Metastasis.
Jan Koster has researched Neuroblastoma in several fields, including Regulation of gene expression, Gene silencing, Transcription factor and Apoptosis. His Cancer study combines topics from a wide range of disciplines, such as Transcriptome, Gene expression, Gene, Somatic cell and Immunology. His Molecular biology research is multidisciplinary, incorporating perspectives in Messenger RNA and N-Myc Proto-Oncogene Protein.
His primary areas of investigation include Cancer research, Neuroblastoma, Cancer, Cell biology and Transcription factor. His studies in Cancer research integrate themes in fields like Somatic cell, Carcinogenesis, Mutation, Transcriptome and In vivo. His study in Neuroblastoma is interdisciplinary in nature, drawing from both Lineage, Regulator, Gene silencing, Epigenetics and Mesenchymal stem cell.
His work in Cancer covers topics such as Gene which are related to areas like Prostate cancer and Oncology. His study looks at the relationship between Cell biology and fields such as Reprogramming, as well as how they intersect with chemical problems. His work carried out in the field of Transcription factor brings together such families of science as Chromatin, Promoter, Regulation of gene expression and Programmed cell death.
Jan Koster mostly deals with Cancer research, Neuroblastoma, Cancer, Cell biology and Gene expression profiling. His Cancer research research includes themes of Immunohistochemistry, Somatic cell, Phenotype, Transcriptome and In vivo. His research integrates issues of SNP, Oncology, Chromatin, Promoter and Locus in his study of Neuroblastoma.
His Cancer study combines topics in areas such as Biobank, DNA methylation, DNA, Frameshift mutation and Gene. His Cell biology research is multidisciplinary, incorporating elements of Stromal cell, Cellular differentiation, Transcription factor, Regulation of gene expression and Innate lymphoid cell. His Gene expression profiling research is multidisciplinary, relying on both TEAD4, Tyrosine kinase and Receptor tyrosine kinase.
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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Dominik Sturm;Hendrik Witt;Hendrik Witt;Volker Hovestadt;Dong Anh Khuong-Quang.
Cancer Cell (2012)
Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients
Marc van de Wetering;Hayley E. Francies;Joshua M. Francis;Joshua M. Francis;Gergana Bounova.
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas
Marcel Kool;Andrey Korshunov;Marc Remke;Marc Remke;David T.W. Jones.
Acta Neuropathologica (2012)
Dissecting the genomic complexity underlying medulloblastoma
David T. W. Jones;Natalie Jäger;Marcel Kool;Thomas Zichner.
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
Jan J. Molenaar;Jan Koster;Danny A. Zwijnenburg;Peter van Sluis.
The landscape of genomic alterations across childhood cancers
Susanne N. Gröbner;Barbara C. Worst;Joachim Weischenfeldt;Joachim Weischenfeldt;Ivo Buchhalter.
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
Kristian W. Pajtler;Kristian W. Pajtler;Hendrik Witt;Martin Sill;David T.W. Jones.
Cancer Cell (2015)
Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations
Tobias Rausch;David T.W. Jones;Marc Zapatka;Adrian M. Stütz.
Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features
Marcel Kool;Jan Koster;Jens Bunt;Nancy E. Hasselt.
PLOS ONE (2008)
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
Javier Muñoz;Daniel E Stange;Arnout G Schepers;Marc van de Wetering.
The EMBO Journal (2012)
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