Dirk Geerts spends much of his time researching Cell biology, Integrin, Molecular biology, Cancer research and Plakin. The study incorporates disciplines such as Endothelium, Biochemistry, Actin cytoskeleton and Blood–brain barrier in addition to Cell biology. The concepts of his Integrin study are interwoven with issues in Hemidesmosome, Cytoplasm, Plectin and LIM domain, Zinc finger.
Dirk Geerts has researched Plectin in several fields, including Hemidesmosome assembly and Dystonin. His Molecular biology course of study focuses on Integrin, beta 6 and Two-hybrid screening and Laminin. His Cancer research research incorporates elements of Cell cycle, Kinase, DNA repair and Gene expression profiling.
His primary areas of study are Cell biology, Cancer research, Molecular biology, Neuroblastoma and Integrin. His research investigates the link between Cell biology and topics such as Gene knockdown that cross with problems in Viability assay. His Cancer research study integrates concerns from other disciplines, such as Cancer, Cell cycle, Kinase and Cell growth.
His research integrates issues of Gene expression and MAPK/ERK pathway in his study of Molecular biology. His work carried out in the field of Neuroblastoma brings together such families of science as Cell migration, Gene, Polyamine and Ornithine decarboxylase. As part of one scientific family, Dirk Geerts deals mainly with the area of Integrin, narrowing it down to issues related to the Plectin, and often Dystonin and Plakin.
His scientific interests lie mostly in Cancer research, Cell biology, Neuroblastoma, Cell and Downregulation and upregulation. His studies in Cancer research integrate themes in fields like Tumor necrosis factor alpha, Immunology, Cancer, Cell culture and Cell growth. Particularly relevant to Progenitor cell is his body of work in Cell biology.
The Neuroblastoma study combines topics in areas such as Apoptosis, Annexin, Harmine, Proteasome and Kinase. His studies deal with areas such as Epithelium, Endogeny, Wild type and Vacuole as well as Cell. His biological study spans a wide range of topics, including Mesenchymal stem cell, Neuroprotection and Voltage-dependent calcium channel.
His primary areas of investigation include Cancer research, Cell biology, Cancer, Regulation of gene expression and Ubiquitin ligase. His research in Cancer research intersects with topics in EC50, Cell growth, Downregulation and upregulation, Immunology and Cell cycle. Dirk Geerts carries out multidisciplinary research, doing studies in Cell biology and Photobleaching.
His Cancer research integrates issues from SOX2, Real-time polymerase chain reaction, Gene knockdown and Lymph node. The study incorporates disciplines such as NF-κB, Signal transduction, Transcription and Transcription factor in addition to Regulation of gene expression. His Ubiquitin ligase study combines topics in areas such as RHOB, RHOA and Subcellular localization.
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Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.
Jan Koster;Dirk Geerts;Dirk Geerts;Bertrand Favre;Luca Borradori.
Journal of Cell Science (2003)
Hemidesmosome Formation Is Initiated by the β4 Integrin Subunit, Requires Complex Formation of β4 and HD1/Plectin, and Involves a Direct Interaction between β4 and the Bullous Pemphigoid Antigen 180
Roel Q.J. Schaapveld;Luca Borradori;Dirk Geerts;Manuel R. van Leusden.
Journal of Cell Biology (1998)
In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma
Shahryar E. Mir;Philip C. De Witt Hamer;Przemek M. Krawczyk;Leonora Balaj.
Cancer Cell (2010)
Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding.
Dirk Geerts;Lionel Fontao;Mirjam G. Nievers;Roel Q.J. Schaapveld.
Journal of Cell Biology (1999)
LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF‐κB activation
Frederik J Verweij;Monique A J van Eijndhoven;Erik S Hopmans;Tineke Vendrig.
The EMBO Journal (2011)
Domain-wide regulation of gene expression in the human genome
Hinco J. Gierman;Mireille H.G. Indemans;Jan Koster;Sandra Goetze.
Genome Research (2007)
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
Jan J. Molenaar;Marli E. Ebus;Dirk Geerts;Jan Koster.
Proceedings of the National Academy of Sciences of the United States of America (2009)
The LIM-only Protein DRAL/FHL2 Binds to the Cytoplasmic Domain of Several α and β Integrin Chains and Is Recruited to Adhesion Complexes
Viktor Wixler;Dirk Geerts;Emmanuel Laplantine;Daniel Westhoff.
Journal of Biological Chemistry (2000)
Retinoic acid induces blood-brain barrier development.
M. R. Mizee;D. Wooldrik;K. A. M. Lakeman;B. van het Hof.
The Journal of Neuroscience (2013)
Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin β subunits
Arjan van der Flier;Ingrid Kuikman;Duco Kramer;Dirk Geerts.
Journal of Cell Biology (2002)
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