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Biology and Biochemistry

D-Index
52
Citations
8157
World Ranking
16837
National Ranking
411

Overview

Dirk Geerts is affiliated with the University of Amsterdam in the Netherlands. Their research spans multiple disciplines primarily within Biochemistry, Genetics and Molecular Biology, and Medicine. Key areas of focus include Molecular Biology, Immunology, Oncology, Hematology, and Cancer Research.

The scientist's recent work covers diverse topics such as Epigenetics and DNA Methylation, Polyamine Metabolism and Applications, Platelet Disorders and Treatments, Ovarian Function and Disorders, Reproductive Biology and Fertility, Pancreatic and Hepatic Oncology Research, and Immune Cell Function and Interaction.

The recent publications of Dirk Geerts include:

  • The depot GnRH agonist protocol improves the live birth rate per fresh embryo transfer cycle, but not the cumulative live birth rate in normal responders: a randomized controlled trial and molecular mechanism study (2020) - Human Reproduction
  • The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis (2021) - Angiogenesis
  • Differential Expression of Polyamine Pathways in Human Pancreatic Tumor Progression and Effects of Polyamine Blockade on Tumor Microenvironment (2021) - Cancers
  • Genetic Engineering of Natural Killer Cells for Enhanced Antitumor Function (2020) - Frontiers in Immunology
  • Osteoprotegerin: Relationship to Breast Cancer Risk and Prognosis (2020) - Frontiers in Oncology

Frequent collaborators in Dirk Geerts's research include Marije Kat, Coert Margadant, Sai Preethi Nakkina, Sarah B. Gitto, and Veethika Pandey. Each of these coauthors has contributed to three publications alongside them.

Publication venues where Dirk Geerts has contributed multiple works are:

  • Frontiers in Oncology (3 papers)
  • Human Reproduction (2 papers)
  • Frontiers in Immunology (2 papers)
  • Haematologica (2 papers)
  • Cancer Research (2 papers)

Best Publications

  • In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma

    Shahryar E. Mir;Philip C. De Witt Hamer;Przemek M. Krawczyk;Leonora Balaj

  • Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

    Jan Koster;Dirk Geerts;Dirk Geerts;Bertrand Favre;Luca Borradori

  • LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF‐κB activation

    Frederik J Verweij;Monique A J van Eijndhoven;Erik S Hopmans;Tineke Vendrig

  • Hemidesmosome Formation Is Initiated by the β4 Integrin Subunit, Requires Complex Formation of β4 and HD1/Plectin, and Involves a Direct Interaction between β4 and the Bullous Pemphigoid Antigen 180

    Roel Q.J. Schaapveld;Luca Borradori;Dirk Geerts;Manuel R. van Leusden

  • Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding.

    Dirk Geerts;Lionel Fontao;Mirjam G. Nievers;Roel Q.J. Schaapveld

  • Retinoic acid induces blood-brain barrier development.

    M.R. Mizee;D. Wooldrik;K.A.M. Lakeman;B. van het Hof

  • Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

    Jan J. Molenaar;Marli E. Ebus;Dirk Geerts;Jan Koster

  • Domain-wide regulation of gene expression in the human genome

    Hinco J. Gierman;Mireille H.G. Indemans;Jan Koster;Sandra Goetze

  • The LIM-only Protein DRAL/FHL2 Binds to the Cytoplasmic Domain of Several α and β Integrin Chains and Is Recruited to Adhesion Complexes

    Viktor Wixler;Dirk Geerts;Emmanuel Laplantine;Daniel Westhoff

  • Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin β subunits

    Arjan van der Flier;Ingrid Kuikman;Duco Kramer;Dirk Geerts

  • Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

    Maarten E. Witte;Philip G. Nijland;Joost A. R. Drexhage;Wouter Gerritsen

  • Polyamine synthesis as a target of MYC oncogenes

    André S. Bachmann;Dirk Geerts

  • Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs

    Bakhos A. Tannous;Mariam Kerami;Petra M. Van der Stoop;Nicholas Kwiatkowski

  • Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

    Ruben van Doorn;Melissa A. Lopes Pinheiro;Gijs Kooij;Kim Lakeman

  • INTERACTION OF THE BULLOUS PEMPHIGOID ANTIGEN 1 (BP230) AND DESMOPLAKIN WITH INTERMEDIATE FILAMENTS IS MEDIATED BY DISTINCT SEQUENCES WITHIN THEIR COOH TERMINUS

    Lionel Fontao;Bertrand Favre;Sara Riou;Dirk Geerts

  • Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma

    Michiel Smits;Thomas Wurdinger;Bert van het Hof;Joost A. R. Drexhage

  • Tumor sialylation impedes T cell mediated anti-tumor responses while promoting tumor associated-regulatory T cells

    Maurizio Perdicchio;Maurizio Perdicchio;Lenneke A. M. Cornelissen;Ingeborg Streng-Ouwehand;Steef Engels

  • The role of the MEIS homeobox genes in neuroblastoma.

    Dirk Geerts;Nathalie Schilderink;Gerda Jorritsma;Rogier Versteeg

  • Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

    Micha Nethe;Eloise C. Anthony;Mar Fernandez-Borja;Rob Dee

  • Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection

    Jessy Hasna;Frédéric Hague;Lise Rodat-Despoix;Dirk Geerts

Frequent Co-Authors

Jan Koster
Jan Koster University of Amsterdam
Rogier Versteeg
Rogier Versteeg University of Amsterdam
Arnoud Sonnenberg
Arnoud Sonnenberg Antoni van Leeuwenhoek Hospital
Helga E. de Vries
Helga E. de Vries University of Amsterdam
Peter L. Hordijk
Peter L. Hordijk University of Amsterdam
Peter Weisbeek
Peter Weisbeek Utrecht University
Jack van Horssen
Jack van Horssen Vrije Universiteit Amsterdam
Marie-José Goumans
Marie-José Goumans Leiden University Medical Center
Ben Berkhout
Ben Berkhout University of Amsterdam
Ronald Dijkman
Ronald Dijkman University of Bern

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