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Biology and Biochemistry

D-Index
79
Citations
17761
World Ranking
4407
National Ranking
32

Overview

Gerhard Wiche is affiliated with the Max F. Perutz Laboratories in Austria and has contributed extensively to the field of biochemistry, genetics, and molecular biology, with a focused emphasis on cell biology and molecular biology. Their research output encompasses topics such as skin and cellular biology, cellular mechanics and interactions, polysaccharides and plant cell walls, glycosylation and glycoproteins, Wnt/β-catenin signaling in development and cancer, muscle physiology and disorders, and plant reproductive biology.

Their recent publications showcase a range of investigations into intermediate filaments and cytoskeletal dynamics. Notable papers include:

  • "The Diversity of Intermediate Filaments in Astrocytes" (2020, Cells)
  • "Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets" (2021, The Journal of Cell Biology)
  • "Plectin-Mediated Intermediate Filament Functions: Why Isoforms Matter" (2021, Cells)
  • "Plectin ensures intestinal epithelial integrity and protects colon against colitis" (2021, Mucosal Immunology)
  • "Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory" (2020, Neuropathology and Applied Neurobiology)

Their frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cells
  • Mucosal Immunology
  • Neuropathology and Applied Neurobiology
  • European Journal of Cell Biology

Gerhard Wiche collaborates regularly with several coauthors, including:

  • Lilli Winter
  • Martin Gregor
  • Lenka Sarnová
  • Gizem Oyman-Eyrilmez
  • Eva Sticová

Their work predominantly spans the study of skin and cellular biology research, with significant contributions to cellular mechanics and interactions. Other areas of expertise include polysaccharides and plant cell wall research as well as glycosylation and glycoproteins. Further domains of investigation involve Wnt/β-catenin signaling pathways relevant to development and cancer, muscle physiology, and plant reproductive biology.

Best Publications

  • Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

    C. Bancher;C. Brunner;H. Lassmann;H. Budka

  • Role of Plectin in Cytoskeleton Organization and Dynamics

    Wiche G

  • Plectin deficiency results in muscular dystrophy with epidermolysis bullosa

    F.J.D. Smith;R.A.J. Eady;I.M. Leigh;J.R. McMillan

  • Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture

    Kerstin Andrä;Hans Lassmann;Reginald Bittner;Sigrid Shorny

  • Defective Expression of Plectin/HD1 in Epidermolysis Bullosa Simplex with Muscular Dystrophy

    Yannick Gache;Stéphane Chavanas;Jean Philippe Lacour;Gerhard Wiche

  • Linking Integrin α6β4-based Cell Adhesion to the Intermediate Filament Cytoskeleton: Direct Interaction between the β4 Subunit and Plectin at Multiple Molecular Sites

    Günther A. Rezniczek;José M. de Pereda;Siegfried Reipert;Gerhard Wiche

  • Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

    Raffaele Teperino;Sabine Amann;Martina Bayer;Sean L. McGee

  • Molecular architecture and function of the hemidesmosome

    Gernot Walko;Maria J. Castañón;Gerhard Wiche

  • MAP1B is required for axon guidance and Is involved in the development of the central and peripheral nervous system.

    Arabella Meixner;Silke Haverkamp;Heinz Wässle;Susanne Führer

  • Not just scaffolding: plectin regulates actin dynamics in cultured cells

    Kerstin Andrä;Branislav Nikolic;Markus Stöcher;Detlev Drenckhahn

  • Occurrence and immunolocalization of plectin in tissues.

    G Wiche;R Krepler;U Artlieb;R Pytela

  • Molecular structure and function of microtubule-associated proteins.

    Gerhard Wiche;Christian Oberkanins;Adolf Himmler

  • Cloning and sequencing of rat plectin indicates a 466-kD polypeptide chain with a three-domain structure based on a central alpha-helical coiled coil.

    G Wiche;B Becker;K Luber;G Weitzer

  • Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions

    B Nikolic;E Mac Nulty;B Mir;G Wiche

  • Association of mitochondria with plectin and desmin intermediate filaments in striated muscle.

    Siegfried Reipert;Ferdinand Steinböck;Irmgard Fischer;Reginald E. Bittner

  • Unusual 5′ Transcript Complexity of Plectin Isoforms: Novel Tissue-Specific Exons Modulate Actin Binding Activity

    Peter Fuchs;Michael Zörer;Günther A. Rezniczek;Daniel Spazierer

  • Novel Features of the Light Chain of Microtubule-associated Protein MAP1B: Microtubule Stabilization, Self Interaction, Actin Filament Binding, and Regulation by the Heavy Chain

    Martin Tögel;Gerhard Wiche;Friedrich Propst

  • Cytoskeleton-associated plectin: in situ localization, in vitro reconstitution, and binding to immobilized intermediate filament proteins.

    R Foisner;F E Leichtfried;H Herrmann;J V Small

  • TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.

    Flávia C. Nery;Juan Zeng;Brian P. Niland;Jeffrey Hewett

  • Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis.

    Alexander H. Stegh;Harald Herrmann;Stefan Lampel;Dieter Weisenberger

Frequent Co-Authors

Roland Foisner
Roland Foisner Medical University of Vienna
Hans Lassmann
Hans Lassmann Medical University of Vienna
Jouni Uitto
Jouni Uitto Thomas Jefferson University
Walter Berger
Walter Berger Medical University of Vienna
Wolfram S. Kunz
Wolfram S. Kunz University of Bonn
Ben Fabry
Ben Fabry University of Erlangen-Nuremberg
Dieter O. Fürst
Dieter O. Fürst University of Bonn
Michael A. Jakupec
Michael A. Jakupec University of Vienna
Christian G. Hartinger
Christian G. Hartinger University of Auckland
Bernhard K. Keppler
Bernhard K. Keppler University of Vienna

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