World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
74
Citations
22805
World Ranking
2086
National Ranking
67

Medicine

D-Index
74
Citations
22829
World Ranking
19348
National Ranking
707

Research.com Recognitions

  • 2019 - Member of Academia Europaea

Overview

Elly M. Hol is affiliated with Utrecht University in the Netherlands and has contributed extensively to the fields of neuroscience, biochemistry, genetics, molecular biology, and medicine. Their research spans multiple subfields including molecular biology, neurology, physiology, cellular and molecular neuroscience, and immunology.

The primary focus of Hol's work lies in investigating mechanisms of neuroinflammation and neurodegeneration, with particular attention to Alzheimer's disease research and treatments. Other significant areas include neuroscience and neuropharmacology research, RNA research and splicing, neurogenesis and neuroplasticity mechanisms, immune cells in cancer, and glioma diagnosis and treatment.

Frequent publication venues for Hol's research include:

  • Glia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain Behavior and Immunity
  • Handbook of Clinical Neurology
  • Frontiers in Cellular Neuroscience

Prominent co-authors frequently collaborating with Hol are:

  • Jinte Middeldorp
  • Jacqueline A. Sluijs
  • Lot D. de Witte
  • R. Jeroen Pasterkamp
  • Christiaan F. M. Huffels

Among recent papers authored or co-authored by Hol are:

  • "Reactive astrocyte nomenclature, definitions, and future directions," 2021, Nature Neuroscience
  • "Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus," 2021, Aging Cell
  • "Profiling Microglia From Alzheimer's Disease Donors and Non-demented Elderly in Acute Human Postmortem Cortical Tissue," 2020, Frontiers in Molecular Neuroscience
  • "A characterization of the molecular phenotype and inflammatory response of schizophrenia patient-derived microglia-like cells," 2020, Brain Behavior and Immunity
  • "Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma," 2022, Journal of Neuroinflammation

In 2019, Elly M. Hol was awarded membership of the Academia Europaea.

Best Publications

  • Reactive astrocyte nomenclature, definitions, and future directions

    Carole Escartin;Elena Galea;András Lakatos;James P. O’Callaghan

  • GFAP in Health and Disease

    J. Middeldorp;E.M. Hol

  • Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system.

    Elly M Hol;Elly M Hol;Elly M Hol;Milos Pekny;Milos Pekny;Milos Pekny

  • Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.

    Rixt F. Riemersma-van der Lek;Dick F. Swaab;Jos Twisk;Elly M. Hol

  • Astrocytes: a central element in neurological diseases

    Milos Pekny;Milos Pekny;Milos Pekny;Marcela Pekna;Marcela Pekna;Marcela Pekna;Albee Messing;Christian Steinhäuser

  • Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients

    Fred W. van Leeuwen;Dominique P. V. de Kleijn;Helma H. van den Hurk;Andrea Neubauer

  • Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

    Inge R Holtman;Divya D Raj;Jeremy A Miller;Wandert Schaafsma

  • Microglia innately develop within cerebral organoids.

    Paul R. Ormel;Renata Vieira de Sá;Emma J. van Bodegraven;Henk Karst

  • The Indispensable Roles of Microglia and Astrocytes during Brain Development

    Kitty Reemst;Stephen C. Noctor;Paul J. Lucassen;Elly M. Hol;Elly M. Hol;Elly M. Hol

  • Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

    Marie Orre;Willem Kamphuis;Lana M Osborn;Lana M Osborn;Anne H P Jansen

  • Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.

    Chotima Böttcher;Stephan Schlickeiser;Marjolein A. M. Sneeboer;Desiree Kunkel

  • Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies.

    C. F. M. G. van Kesteren;H. Gremmels;L. D. de Witte;E. M. Hol;E. M. Hol;E. M. Hol

  • GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease

    Willem Kamphuis;Carlyn Mamber;Martina Moeton;Lieneke Kooijman

  • Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease.

    Lana M. Osborn;Willem Kamphuis;Wytse J. Wadman;Elly M. Hol

  • hUPF2 Silencing Identifies Physiologic Substrates of Mammalian Nonsense-Mediated mRNA Decay

    Jürgen Wittmann;Elly M. Hol;Hans-Martin Jäck

  • Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

    Marie Orre;Willem Kamphuis;Lana M. Osborn;Lana M. Osborn;Jeroen Melief

  • Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

    Willem Kamphuis;Jinte Middeldorp;Jinte Middeldorp;Lieneke Kooijman;Jacqueline A. Sluijs

  • Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

    Kristina Lindsten;Femke M.S. de Vrij;Lisette G.G.C. Verhoef;David F. Fischer

  • Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

    Zhuoran Yin;Divya Raj;Nasrin Saiepour;Debby Van Dam

  • Enteric GFAP expression and phosphorylation in Parkinson's disease.

    Thomas Clairembault;Thomas Clairembault;Willem Kamphuis;Laurène Leclair-Visonneau;Laurène Leclair-Visonneau;Malvyne Rolli-Derkinderen;Malvyne Rolli-Derkinderen

  • Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton

    Reinko F. Roelofs;David F. Fischer;Simone H. Houtman;Jacqueline A. Sluijs

Frequent Co-Authors

Willem Kamphuis
Willem Kamphuis Royal Netherlands Academy of Arts and Sciences
Dick F. Swaab
Dick F. Swaab Royal Netherlands Academy of Arts and Sciences
Milos Pekny
Milos Pekny University of Gothenburg
W.H. Gispen
W.H. Gispen Utrecht University
René S. Kahn
René S. Kahn Icahn School of Medicine at Mount Sinai
Eleonora Aronica
Eleonora Aronica University of Amsterdam
Inge Huitinga
Inge Huitinga Netherlands Institute for Neuroscience
Joost Verhaagen
Joost Verhaagen Netherlands Institute for Neuroscience
Angelo L. Vescovi
Angelo L. Vescovi Casa Sollievo della Sofferenza
Bart J. L. Eggen
Bart J. L. Eggen University Medical Center Groningen

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Elly M. Hol

Trending Scientists