World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
59
Citations
13860
World Ranking
3976
National Ranking
122

Overview

Bart J. L. Eggen is affiliated with the University Medical Center Groningen in the Netherlands. Their research primarily spans the fields of Neuroscience, Immunology and Microbiology, and Medicine, contributing extensively to the understanding of neuroinflammatory and neurodegenerative mechanisms.

The scientist has an extensive publication record in several subfields, including Neurology, Immunology, Molecular Biology, Physiology, and Biological Psychiatry. This multidisciplinary approach supports research that intersects the immune system and brain function, particularly related to neurodegeneration.

Main topics addressed in their work include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Immune cells in cancer
  • Immune Response and Inflammation
  • Alzheimer's disease research and treatments
  • Tryptophan and brain disorders
  • Single-cell and spatial transcriptomics
  • Neurogenesis and neuroplasticity mechanisms

Bart J. L. Eggen has collaborated frequently with several coauthors, among them:

  • Susanne M. Kooistra (33 joint publications)
  • Erik Boddeke (28 joint publications)
  • Nieske Brouwer (28 joint publications)
  • Emma Gerrits (20 joint publications)
  • Laura Kracht (17 joint publications)

The scientist's work appears often in a range of publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory) with 15 publications
  • Glia with 10 publications
  • University of Groningen research database (University of Groningen / Centre for Information Technology) with 7 publications
  • Journal of Neuroinflammation with 3 publications
  • Acta Neuropathologica Communications with 3 publications

Selected recent papers include:

  • "Microglia states and nomenclature: A field at its crossroads," published in Neuron, 2022
  • "Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease," published in Acta Neuropathologica, 2021
  • "Human fetal microglia acquire homeostatic immune-sensing properties early in development," published in Science, 2020
  • "APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints," published in Nature Immunology, 2023
  • "Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction," published in Nature Communications, 2023

This research emphasizes the role of microglia in neuroinflammation, Alzheimer's disease, and immune responses in the brain, with investigations ranging from developmental biology to disease-associated cellular states. The work also addresses the metabolic changes occurring in immune cells during inflammation.

Best Publications

  • Microglia states and nomenclature: A field at its crossroads

    Unknown

  • Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

    Thais F Galatro;Thais F Galatro;Inge R Holtman;Antonio M Lerario;Ilia D Vainchtein

  • Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

    Inge R Holtman;Divya D Raj;Jeremy A Miller;Wandert Schaafsma

  • A novel microglial subset plays a key role in myelinogenesis in developing brain

    Agnieszka Wlodarczyk;Inge R. Holtman;Martin Krueger;Nir Yogev

  • Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.

    Frank Szulzewsky;Andreas Pelz;Xi Feng;Michael Synowitz

  • Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease

    Emma Gerrits;Nieske Brouwer;Susanne M. Kooistra;Maya E. Woodbury

  • Identification of a microglia phenotype supportive of remyelination

    Marta Olah;Sandra Amor;Sandra Amor;Nieske Brouwer;Jonathan Vinet

  • Exercise improves memory acquisition and retrieval in the Y-maze task: relationship with hippocampal neurogenesis.

    Karin Van der Borght;Robbert Havekes;Thomas Bos;Bart J. L. Eggen

  • The Kaleidoscope of Microglial Phenotypes.

    Marissa L. Dubbelaar;Laura Kracht;Bart J. L. Eggen;Erik W. G. M. Boddeke

  • Physical exercise leads to rapid adaptations in hippocampal vasculature: Temporal dynamics and relationship to cell proliferation and neurogenesis

    Karin Van der Borght;Dora E. Kobor-Nyakas;Karin Klauke;Bart J. L. Eggen

  • Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

    Zhuoran Yin;Divya Raj;Nasrin Saiepour;Debby Van Dam

  • Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.

    D Mattei;A Ivanov;C Ferrai;P Jordan

  • Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain

    Divya Raj;Zhuoran Yin;Marjolein Breur;Janine Doorduin

  • Human fetal microglia acquire homeostatic immune-sensing properties early in development

    L. Kracht;M. Borggrewe;S. Eskandar;N. Brouwer

  • Microglial Phenotype and Adaptation

    B. J. L. Eggen;D. Raj;U.-K. Hanisch;H. W. G. M. Boddeke

  • Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease

    Paul D Wes;Inge R Holtman;Erik W G M Boddeke;Thomas Möller

  • APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

    Unknown

  • Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing

    W. Schaafsma;X. Zhang;K. C. van Zomeren;S. Jacobs

  • Priming of microglia in a DNA-repair deficient model of accelerated aging

    Divya D. A. Raj;Dick Jaarsma;Inge R. Holtman;Marta Olah

  • Current concepts in RET-related genetics, signaling and therapeutics

    Ivan Plaza-Menacho;Grzegorz M. Burzynski;Jan Willem de Groot;Bart J.L. Eggen

  • UTF1 is a chromatin-associated protein involved in ES cell differentiation

    Vincent van den Boom;Susanne M. Kooistra;Marije Boesjes;Bart Geverts

  • Morris water maze learning in two rat strains increases the expression of the polysialylated form of the neural cell adhesion molecule in the dentate gyrus but has no effect on hippocampal neurogenesis

    Karin Van der Borght;Alinde E. Wallinga;Paul G. M. Luiten;Bart J. L. Eggen

  • Histone deacetylase inhibitors suppress immune activation in primary mouse microglia.

    Vishnu Kannan;Nieske Brouwer;Uwe-Karsten Hanisch;Tommy Regen

Frequent Co-Authors

Erik Boddeke
Erik Boddeke University Medical Center Groningen
Robert M.W. Hofstra
Robert M.W. Hofstra Erasmus University Rotterdam
Elly M. Hol
Elly M. Hol Utrecht University
Harm J. Krugers
Harm J. Krugers University of Amsterdam
Helmut Kettenmann
Helmut Kettenmann Shenzhen Institutes of Advanced Technology
Debby Van Dam
Debby Van Dam University of Antwerp
Paul J. Lucassen
Paul J. Lucassen University of Amsterdam
Eddy A. Van der Zee
Eddy A. Van der Zee University of Groningen
Paul G.M. Luiten
Paul G.M. Luiten University of Groningen
Stanislas Lyonnet
Stanislas Lyonnet Université Paris Cité

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