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Neuroscience

D-Index
65
Citations
32749
World Ranking
3059
National Ranking
1417

Overview

Oleg Butovsky is affiliated with Brigham and Women's Hospital in the United States. Their research focuses broadly on neuroscience, immunology and microbiology, and medicine, with substantial contributions in several subfields including neurology, immunology, physiology, molecular biology, and biological psychiatry.

The primary themes of Butovsky's work center on neuroinflammation and neurodegeneration mechanisms, which stand out as the most frequent topics in their publications. Other significant areas of study include immune cells in cancer, Alzheimer's disease research and treatments, immune response and inflammation, tryptophan and brain disorders, amyotrophic lateral sclerosis research, and neurogenetic and muscular disorders research.

Recent papers authored or co-authored by Butovsky demonstrate engagement with current topics in neuroscience and immunology. Notable publications include:

  • "Microglia states and nomenclature: A field at its crossroads," 2022, Neuron
  • "Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease," 2020, Journal of Clinical Investigation
  • "TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A," 2022, Nature
  • "Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia," 2021, Neuron
  • "Microglia, Lifestyle Stress, and Neurodegeneration," 2020, Immunity

Butovsky collaborates frequently with a number of researchers, underscoring a networked approach to their investigations. Frequent co-authors include Zhuoran Yin, Charlotte Madore, Kilian Kleemann, Christian Gauthier, and Hemali Phatnani.

Their work has appeared repeatedly in prominent publication venues, reflecting ongoing contributions to high-impact scientific discourse. Key venues include Alzheimer's & Dementia, Nature Communications, Nature Neuroscience, the bioRxiv preprint server from Cold Spring Harbor Laboratory, and Nature.

Best Publications

  • The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

    Susanne Krasemann;Susanne Krasemann;Charlotte Madore;Ron Cialic;Caroline Baufeld

  • Identification of a unique TGF-β–dependent molecular and functional signature in microglia

    Oleg Butovsky;Mark P Jedrychowski;Craig S Moore;Ron Cialic

  • Microglia Function in the Central Nervous System During Health and Neurodegeneration.

    Marco Colonna;Oleg Butovsky

  • Microglia states and nomenclature: A field at its crossroads

    Unknown

  • Depletion of microglia and inhibition of exosome synthesis halt tau propagation

    Hirohide Asai;Seiko Ikezu;Satoshi Tsunoda;Maria Medalla

  • Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood

    Yaniv Ziv;Noga Ron;Oleg Butovsky;Gennady Landa

  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

    Yang Shi;Kaoru Yamada;Shane Antony Liddelow;Shane Antony Liddelow;Scott T. Smith

  • Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells

    Oleg Butovsky;Yaniv Ziv;Adi Schwartz;Gennady Landa

  • Microglial signatures and their role in health and disease

    Oleg Butovsky;Howard L. Weiner

  • Differential roles of microglia and monocytes in the inflamed central nervous system.

    Ryo Yamasaki;Haiyan Lu;Oleg Butovsky;Nobuhiko Ohno

  • TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

    Taylor R. Jay;Crystal M Miller;Paul J Cheng;Leah C Graham

  • Loss of 'homeostatic' microglia and patterns of their activation in active multiple sclerosis.

    Tobias Zrzavy;Simon Hametner;Isabella Wimmer;Oleg Butovsky

  • Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

    Ethan R. Roy;Baiping Wang;Ying-Wooi Wan;Gabriel S. Chiu

  • Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

    Samira Parhizkar;Thomas Arzberger;Matthias Brendel;Gernot Kleinberger

  • Microglial phenotype: is the commitment reversible?

    Michal Schwartz;Oleg Butovsky;Wolfgang Brück;Uwe-Karsten Hanisch

  • Passive or Active Immunization with Myelin Basic Protein Promotes Recovery from Spinal Cord Contusion

    Ehud Hauben;Oleg Butovsky;Uri Nevo;Eti Yoles

  • Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1

    Oleg Butovsky;Maya Koronyo-Hamaoui;Gilad Kunis;Eran Ophir

  • Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective

    Oleg Butovsky;Adolfo E. Talpalar;Keren Ben-Yaakov;Michal Schwartz

  • Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

    Oleg Butovsky;Mark P. Jedrychowski;Ron Cialic;Susanne Krasemann

  • Dark microglia: A new phenotype predominantly associated with pathological states

    Kanchan Bisht;Kaushik P. Sharma;Cynthia Lecours;Maria Gabriela Sánchez

  • TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

    Fargol Mazaheri;Nicolas Snaidero;Nicolas Snaidero;Gernot Kleinberger;Charlotte Madore

  • Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis

    Oleg Butovsky;Gennady Landa;Gennady Landa;Gilad Kunis;Yaniv Ziv

  • Erratum: Identification of a unique TGF-β-dependent molecular and functional signature in microglia (Nature Neuroscience (2014) 17 (131-143))

    Oleg Butovsky;Mark P. Jedrychowski;Craig S. Moore;Ron Cialic

Frequent Co-Authors

Michal Schwartz
Michal Schwartz Weizmann Institute of Science
Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Jack P. Antel
Jack P. Antel McGill University
Richard M. Ransohoff
Richard M. Ransohoff Harvard University
Bruce T. Lamb
Bruce T. Lamb Indiana University
David M. Holtzman
David M. Holtzman Washington University in St. Louis
Shane A. Liddelow
Shane A. Liddelow New York University
Jeffrey D. Rothstein
Jeffrey D. Rothstein Johns Hopkins University
Matthias Brendel
Matthias Brendel Ludwig-Maximilians-Universität München
Marie-Ève Tremblay
Marie-Ève Tremblay University of Victoria

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