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Genetics

D-Index
118
Citations
87230
World Ranking
397
National Ranking
203

Overview

Bin Zhang is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research primarily focuses on the fields of Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, with significant work in the subfields of Physiology, Molecular Biology, Neurology, Cellular and Molecular Neuroscience, and Cell Biology.

The main topics of Bin Zhang's research include:

  • Alzheimer's disease research and treatments
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Prion Diseases and Protein Misfolding
  • Mitochondrial Function and Pathology
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Microtubule and mitosis dynamics

Bin Zhang has published extensively in scientific journals, including multiple papers in notable venues such as Acta Neuropathologica, Nature Communications, Molecular Neurodegeneration, Science Translational Medicine, and Alzheimer's & Dementia.

Selected recent papers by Bin Zhang include:

  • Transmission of tauopathy strains is independent of their isoform composition, 2020, Nature Communications
  • In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics, 2021, Acta Neuropathologica
  • Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease, 2020, Molecular Neurodegeneration
  • A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury, 2023, Science Translational Medicine
  • Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo, 2020, Journal of Neuropathology & Experimental Neurology

Frequent coauthors in Bin Zhang's research include Virginia M.-Y. Lee, John Q. Trojanowski, Lakshmi Changolkar, Hong Xu, and Kurt R. Brunden, indicating collaboration within a consistent network of researchers.

Overall, Bin Zhang's body of work reflects a broad interdisciplinary approach, exploring mechanisms of neurodegenerative diseases, especially Alzheimer's disease, protein misfolding, tau pathology, and neurodegeneration, with translational implications for traumatic brain injury and mitochondrial pathology.

Best Publications

  • Genome-wide atlas of gene expression in the adult mouse brain

    Ed S. Lein;Michael J. Hawrylycz;Nancy Ao;Mikael Ayres

  • The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

    Kristin G. Ardlie;David S. Deluca;Ayellet V. Segrè

  • A General Framework for Weighted Gene Co-Expression Network Analysis

    Bin Zhang;Steve Horvath

  • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

    Luke Jostins;Stephan Ripke;Rinse K Weersma;Richard H Duerr

  • PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

    Peter V. Hornbeck;Bin Zhang;Beth Murray;Jon M. Kornhauser

  • Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

    Kelvin C. Luk;Victoria Kehm;Jenna Carroll;Bin Zhang

  • Defining clusters from a hierarchical cluster tree

    Peter Langfelder;Bin Zhang;Steve Horvath

  • Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

    Yasumasa Yoshiyama;Makoto Higuchi;Bin Zhang;Shu-Ming Huang

  • Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

    Bin Zhang;Chris Gaiteri;Liviu Gabriel Bodea;Zhi Wang

  • Multiphase transport model for relativistic heavy ion collisions

    Zi-Wei Lin;Che Ming Ko;Bao-An Li;Bin Zhang

  • PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

    Peter V. Hornbeck;Jon M. Kornhauser;Sasha Tkachev;Bin Zhang

  • Genetics of gene expression and its effect on disease

    Valur Emilsson;Gudmar Thorleifsson;Bin Zhang;Amy S. Leonardson

  • Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

    Benoit I. Giasson;John E. Duda;John E. Duda;Shawn M. Quinn;Bin Zhang

  • Correction: Corrigendum: Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

    Jialiang Yang;Tao Huang;Francesca Petralia;Quan Long

  • Gene expression elucidates functional impact of polygenic risk for schizophrenia

    Menachem Fromer;Panos Roussos;Solveig K. Sieberts;Jessica S. Johnson

  • Mapping the Genetic Architecture of Gene Expression in Human Liver

    Eric E. Schadt;Cliona Molony;Eugene Chudin;Ke-Ke Hao

  • Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.

    Kelvin C. Luk;Victoria M. Kehm;Bin Zhang;Patrick O’Brien

  • Variations in DNA elucidate molecular networks that cause disease

    Yanqing Chen;Jun Zhu;Pek Yee Lum;Xia Yang

  • Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

    Michiyo Iba;Jing L. Guo;Jennifer D. McBride;Bin Zhang

  • Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

    S. Horvath;B. Zhang;M. Carlson;K. V. Lu

Frequent Co-Authors

Eric E. Schadt
Eric E. Schadt Icahn School of Medicine at Mount Sinai
Vahram Haroutunian
Vahram Haroutunian Icahn School of Medicine at Mount Sinai
Xia Yang
Xia Yang University of California, Los Angeles
Ke Hao
Ke Hao Icahn School of Medicine at Mount Sinai
Jian-Zhi Wang
Jian-Zhi Wang Huazhong University of Science and Technology
Michelle E. Ehrlich
Michelle E. Ehrlich Icahn School of Medicine at Mount Sinai
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Sam Gandy
Sam Gandy Icahn School of Medicine at Mount Sinai
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Kristen J. Brennand
Kristen J. Brennand Icahn School of Medicine at Mount Sinai

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