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Genetics

D-Index
58
Citations
25249
World Ranking
3289
National Ranking
32

Overview

Yardena Samuels is affiliated with the Weizmann Institute of Science in Israel and has a significant presence in the fields of biochemistry, genetics, molecular biology, medicine, immunology, and microbiology. Their research primarily spans molecular biology, immunology, oncology, radiology, nuclear medicine, imaging, and cancer research.

Their scholarly work covers multiple specialized topics, including:

  • Immunotherapy and Immune Responses
  • Vaccines and immunoinformatics approaches
  • Cancer Immunotherapy and Biomarkers
  • Monoclonal and Polyclonal Antibodies Research
  • CAR-T Cell Therapy Research
  • RNA and protein synthesis mechanisms
  • Melanoma and MAPK Pathways

Key recent publications by Yardena Samuels include:

  • "Identification of bacteria-derived HLA-bound peptides in melanoma," 2021, Nature
  • "Melanoma models for the next generation of therapies," 2021, Cancer Cell
  • "Mechanisms of immune activation and regulation: lessons from melanoma," 2022, Nature Reviews Cancer
  • "Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma," 2020, Nature Communications
  • "Anti-tumour immunity induces aberrant peptide presentation in melanoma," 2020, Nature

Their frequent coauthors include:

  • Ronen Levy
  • Yishai Levin
  • Michal Alon
  • Osnat Bartok
  • Polina Greenberg

Their research has been published predominantly in the following scientific venues:

  • Nature Cancer
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature
  • Cancer Cell

Yardena Samuels' work has contributed to the understanding of immune activation, tumor immunity, and melanoma biology, highlighting molecular pathways and immune responses relevant for developing novel therapeutic strategies.

Best Publications

  • High frequency of mutations of the PIK3CA gene in human cancers

    Yardena Samuels;Zhenghe Wang;Alberto Bardelli;Natalie Silliman

  • Genomic Classification of Cutaneous Melanoma

    Rehan Akbani;Kadir C. Akdemir;B. Arman Aksoy;Monique Albert

  • Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

    Paul F. Robbins;Yong Chen Lu;Mona El-Gamil;Yong F. Li

  • Mutant PIK3CA promotes cell growth and invasion of human cancer cells

    Yardena Samuels;Luis A. Diaz;Oleg Schmidt-Kittler;Jordan M. Cummins

  • The PIK3CA gene is mutated with high frequency in human breast cancers

    Kurtis E. Bachman;Pedram Argani;Yardena Samuels;Natalie Silliman

  • The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

    Chuan Hsiang Huang;Chuan Hsiang Huang;Diana Mandelker;Diana Mandelker;Oleg Schmidt-Kittler;Oleg Schmidt-Kittler;Yardena Samuels;Yardena Samuels

  • Oncogenic PI3K and its role in cancer.

    Yardena Samuels;Kajsa Ericson

  • Oncogenic Mutations of PIK3CA in Human Cancers

    Yardena Samuels;Victor E. Velculescu

  • Exome sequencing identifies GRIN2A as frequently mutated in melanoma

    Xiaomu Wei;Vijay Walia;Jimmy C Lin;Jamie K Teer

  • Colorectal cancer: mutations in a signalling pathway.

    D. Williams Parsons;Tian Li Wang;Yardena Samuels;Alberto Bardelli;Alberto Bardelli

  • Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

    David A. Solomon;Taeyeon Kim;Laura A. Diaz-Martinez;Joshlean Fair

  • iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

    Daniele Bergamaschi;Yardena Samuels;Nigel J. O'Neil;Giuseppe Trigiante

  • Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas

    Daniel K. Broderick;Chunhui Di;Timothy J. Parrett;Yardena R. Samuels

  • Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

    Yong Chen Lu;Xin Yao;Jessica S. Crystal;Yong F. Li

  • Analysis of the Tyrosine Kinome in Melanoma Reveals Recurrent Mutations in ERBB4

    Todd D Prickett;Neena S Agrawal;Xiaomu Wei;Kristin E Yates

  • Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion

    Kensuke Tateishi;Hiroaki Wakimoto;A. John Iafrate;Shota Tanaka

  • iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

    Daniele Bergamaschi;Yardena Samuels;Yardena Samuels;Yardena Samuels;Alexandra Sullivan;Marketa Zvelebil

  • UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

    Yochai Wolf;Osnat Bartok;Sushant Patkar;Gitit Bar Eli

  • ASPP1 and ASPP2: Common Activators of p53 Family Members

    Daniele Bergamaschi;Yardena Samuels;Boquan Jin;Sai Duraisingham

  • Analysis of the genome to personalize therapy for melanoma

    M A Davies;Y Samuels

Frequent Co-Authors

Steven A. Rosenberg
Steven A. Rosenberg National Institutes of Health
Victor E. Velculescu
Victor E. Velculescu Johns Hopkins University School of Medicine
Bert Vogelstein
Bert Vogelstein Johns Hopkins University
Arie Admon
Arie Admon Technion – Israel Institute of Technology
Nicholas K. Hayward
Nicholas K. Hayward QIMR Berghofer Medical Research Institute
Abdel G. Elkahloun
Abdel G. Elkahloun National Human Genome Research Institute
Richard A. Scolyer
Richard A. Scolyer Royal Prince Alfred Hospital
Michael A. Davies
Michael A. Davies The University of Texas MD Anderson Cancer Center
Kenneth W. Kinzler
Kenneth W. Kinzler Johns Hopkins University
Eytan Ruppin
Eytan Ruppin National Institutes of Health

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