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Molecular Biology

D-Index
80
Citations
32733
World Ranking
984
National Ranking
74

Overview

Xin Lu is affiliated with the University of Oxford in the United Kingdom. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Molecular Biology, Oncology, Surgery, Cell Biology, and Cancer Research.

The scientist has published extensively on a range of topics. Their main research areas include:

  • Cancer Immunotherapy and Biomarkers
  • Esophageal Cancer Research and Treatment
  • Cancer-related Molecular Pathways
  • RNA Modifications and Cancer
  • Cellular Mechanics and Interactions
  • Epigenetics and DNA Methylation
  • Cancer Cells and Metastasis

Xin Lu has contributed to a number of recent publications. Notable papers include:

  • "Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site", 2020, published in Cancer Cell
  • "A deep learning framework for quality assessment and restoration in video endoscopy", 2020, published in Medical Image Analysis
  • "Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer", 2021, published in Theranostics
  • "Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1", 2022, published in EMBO Reports
  • "Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution", 2020, published in Molecular Cell

The scientist frequently publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cell Death and Disease
  • SSRN Electronic Journal
  • Cancer Cell

Xin Lu collaborates regularly with several co-authors, including:

  • Richard Owen
  • Mark R. Middleton
  • Felix Zhou
  • Thomas Carroll
  • Benjamin Schuster-Böckler

Best Publications

  • Live or let die: the cell's response to p53

    Karen H. Vousden;Xin Lu

  • Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

    Galluzzi L;Vitale I;Vitale I;Vitale I;Abrams Jm;Alnemri Es

  • Comprehensive genomic profiles of small cell lung cancer

    Julie George;Jing Shan Lim;Se Jin Jang;Yupeng Cun

  • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

    Martin Peifer;Lynnette Fernández-Cuesta;Martin L. Sos;Julie George

  • Differential induction of transcriptionally active p53 following UV or ionizing radiation : defects in chromosome instability syndromes ?

    Xin Lu;David P. Lane

  • X chromosomal abnormalities in basal-like human breast cancer

    Andrea L. Richardson;Zhigang C. Wang;Arcangela De Nicolo;Arcangela De Nicolo;Xin Lu

  • ASPP proteins specifically stimulate the apoptotic function of p53.

    Yardena Samuels-Lev;Daniel J. O'Connor;Daniele Bergamaschi;Giuseppe Trigiante

  • A genomics-based classification of human lung tumors

    Danila Seidel;Thomas Zander;Lukas C. Heukamp;Martin Peifer

  • p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis.

    Daniele Bergamaschi;Milena Gasco;Louise Hiller;Alexandra Sullivan

  • A complex barcode underlies the heterogeneous response of p53 to stress

    Fiona Murray-Zmijewski;Elizabeth A. Slee;Xin Lu

  • High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers.

    Steffen Fredersdorf;Jorges Burns;Alistair M. Milne;Graham Packham

  • iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human

    Daniele Bergamaschi;Yardena Samuels;Nigel J. O'Neil;Giuseppe Trigiante

  • E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

    J K Hsieh;S Fredersdorf;T Kouzarides;K Martin

  • Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.

    S Rowan;R L Ludwig;Y Haupt;S Bates

  • To die or not to die: how does p53 decide?

    Elizabeth A Slee;Daniel J O'Connor;Xin Lu

  • Functional regulation of p73 and p63: development and cancer

    Gerry Melino;Xin Lu;Milena Gasco;Tim Crook

  • Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia

    Xia Wang;Hong Ouyang;Yusuke Yamamoto;Pooja Ashok Kumar

  • RB Regulates the Stability and the Apoptotic Function of p53 via MDM2

    Jung-Kuang Hsieh;Florence S.G Chan;Daniel J O’Connor;Sibylle Mittnacht

  • Epithelial cell polarity: a major gatekeeper against cancer?

    C Royer;X Lu

  • Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo.

    Alexandra Sullivan;Nelofer Syed;Milena Gasco;Daniele Bergamaschi

Frequent Co-Authors

Robert D. Goldin
Robert D. Goldin Imperial College London
Jens Rittscher
Jens Rittscher University of Oxford
Gerry Melino
Gerry Melino University of Rome Tor Vergata
David P. Lane
David P. Lane Karolinska Institute
Yardena Samuels
Yardena Samuels Weizmann Institute of Science
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Hextan Y.S. Ngan
Hextan Y.S. Ngan University of Hong Kong
Karen H. Vousden
Karen H. Vousden The Francis Crick Institute
Ingo Helbig
Ingo Helbig Children's Hospital of Philadelphia

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