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Molecular Biology

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107
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406
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Research.com Recognitions

  • 2020 - Fellow of the Royal Society, United Kingdom
  • 2008 - Member of the National Academy of Sciences
  • 2005 - Member of the National Academy of Medicine (NAM)
  • 2001 - Fellow of the American Academy of Microbiology DNA Viruses
  • 2000 - Fellow of the American Academy of Arts and Sciences

Overview

Carol Prives is affiliated with Columbia University in the United States. Their research spans multiple fields, with a primary focus on biochemistry, genetics, molecular biology, and medicine. The subfields of their work include molecular biology, oncology, cancer research, pulmonary and respiratory medicine, and biotechnology.

The main topics covered by Carol Prives' research include cancer-related molecular pathways, RNA modifications and cancer, epigenetics and DNA methylation, ferroptosis and cancer prognosis, cancer research and treatments, cancer lipids and metabolism, and ubiquitin and proteasome pathways.

Carol Prives has published extensively, contributing notably to journals such as Cancer Research, Genes & Development, Cancer Discovery, bioRxiv (Cold Spring Harbor Laboratory), and Proceedings of the National Academy of Sciences.

  • MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling (2020, Genes & Development)
  • GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma (2022, Cancer Research)
  • The roles and regulation of MDM2 and MDMX: it is not just about p53 (2021, Genes & Development)
  • p21 can be a barrier to ferroptosis independent of p53 (2020, Aging)
  • p53 at the crossroads of tumor immunity (2024, Nature Cancer)

The scientist frequently collaborates with a number of coauthors, including Gizem Efe, Rafaela Muniz de Queiroz, Anil K. Rustgi, James J. Manfredi, and David Tong.

Carol Prives' contributions have been recognized by several honors. These include being a Fellow of the Royal Society in the United Kingdom since 2020, a Member of the National Academy of Sciences since 2008, and a Member of the National Academy of Medicine since 2005. Earlier distinctions include being named a Fellow of the American Academy of Microbiology in 2001 for work related to DNA viruses and a Fellow of the American Academy of Arts and Sciences since 2000.

Best Publications

  • Blinded by the Light: The Growing Complexity of p53

    Karen H. Vousden;Carol Prives

  • p53: puzzle and paradigm.

    L J Ko;C Prives

  • Enchanced phosphorylation of P53 by ATM in response to DNA damage

    Yosef Shiloh;Nehama I. Smorodinsky

  • DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

    Sheau-Yann Shieh;Masako Ikeda;Yoichi Taya;Carol Prives

  • The p53 pathway

    Carol Prives;Peter A. Hall

  • Mutant p53: one name, many proteins

    William A. Freed-Pastor;Carol Prives

  • Identification of p53 as a sequence-specific DNA-binding protein

    Scott E. Kern;Kenneth W. Kinzler;Arthur Bruskin;David Jarosz

  • A role for ATR in the DNA damage-induced phosphorylation of p53

    Randal S. Tibbetts;Kathryn M. Brumbaugh;Josie M. Williams;Jann N. Sarkaria

  • The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

    Sheau-Yann Shieh;Jinwoo Ahn;Katsuyuki Tamai;Yoichi Taya

  • p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

    Xinbin Chen;Linda J. Ko;Lata Jayaraman;Carol Prives

  • Regulation of p53 activity through lysine methylation

    Sergei Chuikov;Julia K. Kurash;Jonathan R. Wilson;Bing Xiao

  • SIGNALING TO P53 : BREAKING THE MDM2-P53 CIRCUIT

    Carol Prives

  • Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRB is a critical determinant in blocking DNA replication and in preventing endoreduplication

    Alexander B. Niculescu;Xinbin Chen;Monique Smeets;Ludger Hengst

  • Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

    William A. Freed-Pastor;Hideaki Mizuno;Xi Zhao;Anita Langerød

  • Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

    Sawako Suzuki;Tomoaki Tanaka;Masha V. Poyurovsky;Hidekazu Nagano

  • E1A signaling to p53 involves the p19(ARF) tumor suppressor.

    Elisa de Stanchina;Mila E. McCurrach;Frederique Zindy;Sheau-Yann Shieh

  • Wild-type p53 activates transcription in vitro

    George Farmer;Jill Bargonetti;Hua Zhu;Paula Friedman

  • Transcriptional regulation by p53.

    Rachel Beckerman;Carol Prives

  • PML is induced by oncogenic ras and promotes premature senescence

    Gerardo Ferbeyre;Elisa de Stanchina;Emmanuelle Querido;Nicole Baptiste

  • Transcriptional regulation by p53: one protein, many possibilities.

    O Laptenko;C Prives

Frequent Co-Authors

James L. Manley
James L. Manley Columbia University
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center
Xinbin Chen
Xinbin Chen University of California, Davis
Yoichi Taya
Yoichi Taya National University of Singapore
James J. Manfredi
James J. Manfredi Icahn School of Medicine at Mount Sinai
Moshe Oren
Moshe Oren Weizmann Institute of Science
Carlos Cordon-Cardo
Carlos Cordon-Cardo Icahn School of Medicine at Mount Sinai
Arnold J. Levine
Arnold J. Levine Institute for Advanced Study
Anne Lise Børresen-Dale
Anne Lise Børresen-Dale Oslo University Hospital
Harmen J. Bussemaker
Harmen J. Bussemaker Columbia University

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