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Molecular Biology
Sweden
2026
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Genetics and Molecular Biology
Sweden
2024

D-Index & Metrics

Molecular Biology

D-Index
152
Citations
121483
World Ranking
77
National Ranking
2

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Sweden Leader Award
  • 2025 - Research.com Molecular Biology in Sweden Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Sweden Leader Award
  • 2023 - Research.com Molecular Biology in Sweden Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Sweden Leader Award
  • 2004 - Buchanan Medal, Royal Society (UK) in recognition of his discovery of the p53 protein and the subsequent research in which this basic discovery has been followed through to clinical application, exploiting the p53 pathway to find new treatments for cancer
  • 1998 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 1992 - Fellow of the Royal Society of Edinburgh
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

David P. Lane is affiliated with the Karolinska Institute in Sweden. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a significant focus on cancer-related molecular pathways and intracellular regulatory mechanisms.

Their recent publications include:

  • Combining native and 'omics' mass spectrometry to identify endogenous ligands bound to membrane proteins, 2020, Nature Methods
  • Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells, 2020, Proceedings of the National Academy of Sciences
  • bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA), 2020, Proceedings of the National Academy of Sciences
  • A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma, 2020, Cell Reports
  • Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity, 2022, Proceedings of the National Academy of Sciences

Their work covers several main fields of study:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of scholarly focus include:

  • Molecular Biology
  • Oncology
  • Immunology
  • Radiology, Nuclear Medicine and Imaging
  • Biotechnology

Key topics within their research include:

  • Cancer-related Molecular Pathways
  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Cancer Research and Treatments
  • Chemical Synthesis and Analysis
  • Monoclonal and Polyclonal Antibodies Research

Frequent coauthors collaborating on their research are:

  • Christopher J. Brown
  • Dilraj Lama
  • Saikiran K. Sedimbi
  • Marika Nestor
  • Anthony W. Partridge

Common publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Zenodo (CERN European Organization for Nuclear Research)
  • Scientific Reports

In addition to articles, David P. Lane has contributed to book publications, notably the title Beyond Bars published by Policy Press in 2023.

The scientist has received recognition through several awards, such as the Buchanan Medal from the Royal Society (UK) in 2004, awarded in recognition of their work on the discovery of the p53 protein and its applications in cancer treatment. Other honors include the Paul Ehrlich and Ludwig Darmstaedter Prize in 1998, fellowship in the Royal Society of Edinburgh in 1992, and membership in the European Molecular Biology Organization.

Best Publications

  • Antibodies: A Laboratory Manual

    Ed Harlow;David Lane

  • Surfing the p53 network

    Bert Vogelstein;David Lane;Arnold J. Levine

  • p53, guardian of the genome

    David P. Lane

  • T Antigen Is Bound to a Host Protein in Sv40-Transformed Cells

    D. P. Lane;D. P. Lane;L. V. Crawford

  • p53 in health and disease.

    Karen H. Vousden;David P. Lane

  • International network of cancer genome projects

    Thomas J. Hudson;Thomas J. Hudson;Warwick Anderson;Axel Aretz;Anna D. Barker

  • Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms

    P. A. Hall;D. A. Levison;A. L. Woods;C. C.-W. Yu

  • Increased expression of mutant forms of p53 oncogene in primary lung cancer.

    R Iggo;K Gatter;J Bartek;D Lane

  • Regulation of the specific DNA binding function of p53

    T.R. Hupp;D.W. Meek;C.A. Midgley;D.P. Lane

  • Awakening guardian angels: drugging the p53 pathway

    Christopher J. Brown;Sonia Lain;Chandra S. Verma;Alan R. Fersht

  • p53: oncogene or anti-oncogene?

    David P. Lane;Sam Benchimol

  • p53 isoforms can regulate p53 transcriptional activity

    Jean-Christophe Bourdon;Kenneth Fernandes;Fiona Murray-Zmijewski;Geng Liu

  • Differential induction of transcriptionally active p53 following UV or ionizing radiation : defects in chromosome instability syndromes ?

    Xin Lu;David P. Lane

  • Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form.

    N.H. Waseem;D.P. Lane

  • High levels of p53 protein in UV-irradiated normal human skin.

    Hall Pa;McKee Ph;Menage Hd;Dover R

  • Drugging the p53 pathway: understanding the route to clinical efficacy

    Kian Hoe Khoo;Chandra S. Verma;Chandra S. Verma;Chandra S. Verma;David P. Lane

  • SUMO-1 modification activates the transcriptional response of p53

    Manuel S. Rodriguez;Joana M. P. Desterro;Sonia Lain;Carol A. Midgley

  • Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

    Bartek J;Iggo R;Gannon J;Lane Dp

  • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

    Anita J. Merritt;Christopher S. Potten;Christopher J. Kemp;John A. Hickman

  • p53 in tumour pathology: can we trust immunohistochemistry?--Revisited!

    Peter A. Hall;David P. Lane

Frequent Co-Authors

Chandra S. Verma
Chandra S. Verma Agency for Science, Technology and Research
Jean-Christophe Bourdon
Jean-Christophe Bourdon University of Dundee
Peter M. Fischer
Peter M. Fischer University of Nottingham
David M. Glover
David M. Glover California Institute of Technology
Curtis C. Harris
Curtis C. Harris National Institutes of Health
Ted R. Hupp
Ted R. Hupp University of Edinburgh
Alastair M. Thompson
Alastair M. Thompson Baylor College of Medicine
David W. Meek
David W. Meek University of Dundee
Sara E. Mole
Sara E. Mole University College London
Michael J. R. Stark
Michael J. R. Stark University of Dundee

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