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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
115
Citations
53727
World Ranking
782
National Ranking
13

Medicine

D-Index
114
Citations
53799
World Ranking
4689
National Ranking
136

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Pierre Hainaut is affiliated with Grenoble Alpes University in France and has a robust publication record primarily in medicine and biochemistry, genetics, and molecular biology. Their research encompasses numerous topics focusing on cancer-related molecular mechanisms and diagnostics, as well as cardiovascular and epidemiological studies.

The main fields of study for this researcher include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Subfields of study include:

  • Molecular Biology
  • Oncology
  • Cancer Research
  • Cardiology and Cardiovascular Medicine
  • Epidemiology

Key research topics associated with their work are:

  • Cancer-related Molecular Pathways
  • Cancer Genomics and Diagnostics
  • Hedgehog Signaling Pathway Studies
  • Epigenetics and DNA Methylation
  • Atrial Fibrillation Management and Outcomes
  • Venous Thromboembolism Diagnosis and Management
  • Genetic factors in colorectal cancer

Frequent coauthors in their publications include:

  • Christian P. Kratz
  • Emilie Montellier
  • David Malkin
  • Claire Freyçon
  • Sandrine Blanchet

Notable recent papers by Pierre Hainaut are:

  • The TP53 Database: transition from the International Agency for Research on Cancer to the US National Cancer Institute, 2022, Cell Death and Differentiation
  • Analysis of the Li-Fraumeni Spectrum Based on an International Germline TP53 Variant Data Set, 2021, JAMA Oncology
  • A novel whole blood gene expression signature for asthma, dermatitis, and rhinitis multimorbidity in children and adolescents, 2020, Allergy
  • Heterozygous BRCA1 and BRCA2 and Mismatch Repair Gene Pathogenic Variants in Children and Adolescents With Cancer, 2022, JNCI Journal of the National Cancer Institute
  • Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement, 2020, Nanoscale

The researcher frequently publishes in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Current Opinion in Oncology
  • JNCI Journal of the National Cancer Institute
  • Cell Death and Differentiation
  • The American Journal of Medicine

Best Publications

  • A global view of hepatocellular carcinoma: trends, risk, prevention and management.

    Ju Dong Yang;Pierre Hainaut;Gregory J. Gores;Amina Amadou

  • TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

    Magali Olivier;Monica Hollstein;Pierre Hainaut

  • Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.

    Audrey Petitjean;Ewy Mathe;Ewy Mathe;Shunsuke Kato;Chikashi Ishioka

  • The IARC TP53 database: new online mutation analysis and recommendations to users.

    Magali Olivier;Ros Eeles;Monica Hollstein;Mohammed A. Khan

  • A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

    Rayjean J. Hung;James D. Mckay;Valerie Gaborieau;Paolo Boffetta

  • Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers

    Gerd P Pfeifer;Mikhail F Denissenko;Magali Olivier;Natalia Tretyakova

  • p53 and human cancer: the first ten thousand mutations.

    Pierre Hainaut;Monica Hollstein

  • TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

    A. Petitjean;Maria I.A.S.W. Achatz;Anne-Lise Borresen-Dale;P. Hainaut

  • The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

    Magali Olivier;Anita Langerød;Patrizia Carrieri;Jonas Bergh

  • PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

    Jeremy M.R. Lambert;Jeremy M.R. Lambert;Petr Gorzov;Dimitry B. Veprintsev;Maja Söderqvist

  • Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype.

    Magali Olivier;David E. Goldgar;Nayanta Sodha;Hiroko Ohgaki

  • Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance.

    Emmanuelle Gormally;Emmanuelle Gormally;Elodie Caboux;Paolo Vineis;Pierre Hainaut

  • IARC Database of p53 gene mutations in human tumors and cell lines: Updated compilation, revised formats and new visualisation tools

    Pierre Hainaut;T. Hernandez;Alan J. Robinson;Patricia Rodriguez-Tomé

  • Association between pre-diagnostic circulating vitamin D concentration and risk of colorectal cancer in European populations:a nested case-control study

    Mazda Jenab;H. Bas Bueno-de-Mesquita;Pietro Ferrari;Franzel J.B. van Duijnhoven

  • Redox Modulation of p53 Conformation and Sequence-specific DNA Binding in Vitro

    Pierre Hainaut;Jo Milner

  • Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke.

    Pierre Hainaut;Gerd P. Pfeifer

  • Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers

    Sophie Rousseaux;Alexandra Debernardi;Baptiste Jacquiau;Anne Laure Vitte

  • Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: a review.

    Montesano R;Hollstein M;Hainaut P

  • Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study.

    P Vineis;L Airoldi;F Veglia;L Olgiati

  • Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

    Pierre Hainaut;Thierry Soussi;Benny Shomer;M. Hollstein

Frequent Co-Authors

Ruggero Montesano
Ruggero Montesano International Agency For Research On Cancer
Paolo Boffetta
Paolo Boffetta Stony Brook Medicine
Elisabeth Brambilla
Elisabeth Brambilla Grenoble Alpes University
Elio Riboli
Elio Riboli Imperial College London
Paolo Vineis
Paolo Vineis Imperial College London
Kim Overvad
Kim Overvad Aarhus University
Hilton Whittle
Hilton Whittle London School of Hygiene & Tropical Medicine
Janet Hall
Janet Hall National Institute of Environmental Health Sciences
Gregory D. Kirk
Gregory D. Kirk Johns Hopkins University
Zdenko Herceg
Zdenko Herceg International Agency For Research On Cancer

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