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Jean-Christophe Bourdon

Jean-Christophe Bourdon

D-Index & Metrics

Molecular Biology

D-Index
48
Citations
10258
World Ranking
2674
National Ranking
209

Overview

Jean-Christophe Bourdon is affiliated with the University of Dundee in the United Kingdom. Their research primarily focuses on areas within biochemistry, genetics, molecular biology, and medicine. The scientist's work is particularly concentrated in molecular biology, oncology, cancer research, biotechnology, and immunology.

The scientist has contributed to multiple key topics across their career, including:

  • Cancer-related Molecular Pathways
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Cancer Research and Treatments
  • Ubiquitin and proteasome pathways
  • Cancer Genomics and Diagnostics
  • Immunotherapy and Immune Responses

Jean-Christophe Bourdon's recent publications cover various aspects of cancer biology and molecular mechanisms involving the p53 protein and RNA modifications. Notable papers include:

  • "Ribosomal RNA 2'O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer" (2020, NAR Cancer)
  • "The pleiotropic role of p53 in functional/dysfunctional neurons: focus on pathogenesis and diagnosis of Alzheimer's disease" (2020, Alzheimer's Research & Therapy)
  • "Adaptive homeostasis and the p53 isoform network" (2021, EMBO Reports)
  • "Inhibition of nonsense-mediated decay rescues p53β/γ isoform expression and activates the p53 pathway in MDM2-overexpressing and select p53-mutant cancers" (2021, Journal of Biological Chemistry)
  • "Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells" (2021, Nature Communications)

The scientist frequently publishes in journals such as eLife, bioRxiv (Cold Spring Harbor Laboratory), NAR Cancer, Nature Communications, and Cell Death and Disease. Across these venues, Jean-Christophe Bourdon has multiple publications reflecting sustained research activity.

Collaborations have been an important part of their work, with several frequent co-authors including Alexandra Diot, Susan E. Bray, Lee B. Jordan, Antony W. Braithwaite, and Kira Groen.

Best Publications

  • p53 isoforms can regulate p53 transcriptional activity

    Jean-Christophe Bourdon;Kenneth Fernandes;Fiona Murray-Zmijewski;Geng Liu

  • Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity

    Dimitris P. Xirodimas;Mark K. Saville;Jean Christophe Bourdon;Ronald T. Hay

  • p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress

    Murray-Zmijewski F;Lane Dp;Bourdon Jc

  • Uncovering the role of p53 splice variants in human malignancy: a clinical perspective

    Sylvanie Surget;Marie P Khoury;Jean-Christophe Bourdon

  • p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

    Kaori Fujita;Abdul M. Mondal;Izumi Horikawa;Giang H. Nguyen;Giang H. Nguyen

  • p53 and its isoforms in cancer

    Bourdon Jc

  • p53 Acts as a Safeguard of Translational Control by Regulating Fibrillarin and rRNA Methylation in Cancer

    Virginie Marcel;Virginie Marcel;Sandra E. Ghayad;Sandra E. Ghayad;Stéphane Belin;Stéphane Belin;Gabriel Therizols;Gabriel Therizols

  • The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

    Gaynor J Bates;Samantha M Nicol;Brian J Wilson;Anne-Marie F Jacobs

  • The Isoforms of the p53 Protein

    Marie P. Khoury;Jean-Christophe Bourdon

  • DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

    Fanny Lemée;Valérie Bergoglio;Anne Fernandez-Vidal;Alice Machado-Silva

  • Biological functions of p53 isoforms through evolution: lessons from animal and cellular models

    Virginie Marcel;Marie-Laure Dichtel-Danjoy;C. Sagne;C. Sagne;C. Sagne;H. Hafsi

  • p53 Isoforms: An Intracellular Microprocessor?

    Marie P. Khoury;Jean-Christophe Bourdon

  • Further characterisation of the p53 responsive element – identification of new candidate genes for trans -activation by p53

    Jean-Christophe Bourdon;Valérie Deguin-Chambon;Jean-Claude Lelong;Philippe Dessen

  • Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo

    Mark K. Saville;Alison Sparks;Dimitris P. Xirodimas;Julie Wardrop

  • p53 isoform Δ113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish

    Jun Chen;Sok Meng Ng;Changqing Chang;Zhenhai Zhang

  • Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis.

    Dany Munsch;Rie Watanabe-Fukunaga;Jean Christophe Bourdon;Shigekasu Nagata

  • Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

    J.-C. Bourdon;J. Renzing;P.L. Robertson;K.N. Fernandes

  • Δ160p53 is a novel N-terminal p53 isoform encoded by Δ133p53 transcript.

    Virginie Marcel;Stéphane Perrier;Mustapha Aoubala;Sylvain Ageorges

  • p53 Isoforms: Key Regulators of the Cell Fate Decision.

    Sebastien M. Joruiz;Jean-Christophe Bourdon

  • p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage

    Mustapha Aoubala;F. Murray-Zmijewski;Marie Khoury;Marie Khoury;K. Fernandes

Frequent Co-Authors

David P. Lane
David P. Lane Karolinska Institute
Alastair M. Thompson
Alastair M. Thompson Baylor College of Medicine
Bjørn Tore Gjertsen
Bjørn Tore Gjertsen Haukeland University Hospital
Curtis C. Harris
Curtis C. Harris National Institutes of Health
Antony W. Braithwaite
Antony W. Braithwaite University of Otago
Bruno Lina
Bruno Lina Claude Bernard University Lyon 1
Alain Puisieux
Alain Puisieux Claude Bernard University Lyon 1
Philippe Bouvet
Philippe Bouvet École Normale Supérieure de Lyon
Øystein Bruserud
Øystein Bruserud University of Bergen

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