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Molecular Biology
Israel
2026
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Genetics and Molecular Biology
Israel
2024

D-Index & Metrics

Molecular Biology

D-Index
147
Citations
87138
World Ranking
91
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Israel Leader Award
  • 2025 - Research.com Molecular Biology in Israel Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Israel Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Israel Leader Award
  • 2023 - Research.com Molecular Biology in Israel Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Israel Leader Award
  • 2019 - Member of the National Academy of Sciences
  • 2013 - Member of the National Academy of Medicine (NAM)
  • 2007 - Member of Academia Europaea
  • 2007 - Fellow of the American Academy of Arts and Sciences
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Moshe Oren is affiliated with the Weizmann Institute of Science in Israel and has a robust publication record in biochemistry, genetics, molecular biology, and medicine. Their research focuses primarily on molecular biology and oncology, with significant contributions to cancer research, cell biology, and pulmonary and respiratory medicine.

Their main topics of investigation include:

  • Cancer-related Molecular Pathways
  • Cancer Genomics and Diagnostics
  • Hippo pathway signaling and YAP/TAZ
  • Cancer Research and Treatments
  • Epigenetics and DNA Methylation
  • Ubiquitin and proteasome pathways
  • MicroRNA in disease regulation

Oren has coauthored extensively with several researchers, frequently collaborating with Yael Aylon, Saptaparna Mukherjee, Nishanth Belugali Nataraj, Yosef Yarden, and Ori Hassin.

Their publications are often found in prominent scientific venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Proceedings of the National Academy of Sciences
  • Nature Communications
  • Cell

Notable recent papers include:

  • "Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers" (2020, Cell)
  • "Drugging p53 in cancer: one protein, many targets" (2022, Nature Reviews Drug Discovery)
  • "The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic" (2020, Nature)
  • "TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment" (2021, Proceedings of the National Academy of Sciences)
  • "AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer" (2022, Cancer Discovery)

Moshe Oren's scientific contributions have been recognized by several memberships and fellowships in prestigious organizations. These include:

  • Member of the National Academy of Sciences (2019)
  • Member of the National Academy of Medicine (NAM) (2013)
  • Fellow of the American Academy of Arts and Sciences (2007)
  • Member of Academia Europaea (2007)
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Mdm2 promotes the rapid degradation of p53

    Ygal Haupt;Ruth Maya;Anat Kazaz;Moshe Oren

  • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

    E Yonish-Rouach;D Resnitzky;J Lotem;L Sachs

  • The first 30 years of p53: growing ever more complex

    Arnold J. Levine;Moshe Oren

  • mdm2 expression is induced by wild type p53 activity.

    Y. Barak;T. Juven;R. Haffner;M. Oren

  • Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

    Nina Raver-Shapira;Efi Marciano;Eti Meiri;Yael Spector

  • Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

    C A Finlay;P W Hinds;T H Tan;D Eliyahu

  • Decision making by p53: life, death and cancer.

    M Oren

  • Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

    Noa Rivlin;Ran Brosh;Moshe Oren;Varda Rotter

  • p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

    Martina Müller;Sylvia Wilder;Detlev Bannasch;David Israeli

  • Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

    Ayuko Hoshino;Ayuko Hoshino;Han Sang Kim;Han Sang Kim;Linda Bojmar;Linda Bojmar;Linda Bojmar;Kofi Ennu Gyan

  • Participation of p53 cellular tumour antigen in transformation of normal embryonic cells.

    Daniel Eliyahu;Avraham Raz;Peter Gruss;David Givol

  • Wild-type p53 can inhibit oncogene-mediated focus formation.

    Daniel Eliyahu;Dan Michalovitz;Siona Eliyahu;Orit Pinhasi-Kimhi

  • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

    Dan Michalovitz;Orna Halevy;Moshe Oren

  • The p53-Mdm2 module and the ubiquitin system.

    Dan Michael;Moshe Oren

  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.

    Ruth Maya;Moshe Balass;Seong-Tae Kim;Dganit Shkedy

  • Mutant p53 Gain-of-Function in Cancer

    Moshe Oren;Varda Rotter

  • Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study

    Ruth Lev Bar-Or;Ruth Maya;Lee A. Segel;Uri Alon

  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

    L. Galluzzi;L. Galluzzi;L. Galluzzi;S. A. Aaronson;J. Abrams;E. S. Alnemri

  • Regulation of the p53 Tumor Suppressor Protein

    Moshe Oren

Frequent Co-Authors

Varda Rotter
Varda Rotter Weizmann Institute of Science
Giovanni Blandino
Giovanni Blandino McMaster University
Ygal Haupt
Ygal Haupt Peter MacCallum Cancer Centre
Eyal Gottlieb
Eyal Gottlieb Technion – Israel Institute of Technology
Gerry Melino
Gerry Melino University of Rome Tor Vergata
David Givol
David Givol Weizmann Institute of Science
Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Eli Pikarsky
Eli Pikarsky Hebrew University of Jerusalem
Yitzhak Pilpel
Yitzhak Pilpel Weizmann Institute of Science
Adi Kimchi
Adi Kimchi Weizmann Institute of Science

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