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D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
16263
World Ranking
12355
National Ranking
5287

Overview

Brian Zambrowicz is affiliated with Regeneron in the United States. Their research spans multiple fields with a focus on biochemistry, genetics, and molecular biology, complemented by significant work in medicine. The primary subfields addressed in their publications include molecular biology, genetics, neurology, epidemiology, and physiology.

The main topics of Brian Zambrowicz's scientific contributions focus on areas such as CRISPR and genetic engineering, RNA regulation and disease, diabetes treatment and management, genetic associations and epidemiology, metabolism related to diabetes and cancer, liver disease diagnosis and treatment, and pancreatic function in relation to diabetes.

Their frequent co-authors include George D. Yancopoulos, Andrew Murphy, Aris N. Economides, Mark W. Sleeman, and Judith Y. Altarejos, indicating close collaboration within a network of researchers.

Brian Zambrowicz has published extensively in several venues, with repeated publications in bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, New England Journal of Medicine, Nature Communications, and Stem Cell Reports.

Selected recent papers exemplify the scope and impact of their research:

  • CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis, 2021, New England Journal of Medicine
  • Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity, 2021, Science
  • Germline Mutations in CIDEB and Protection against Liver Disease, 2022, New England Journal of Medicine
  • Autophagy protects tumors from T cell-mediated cytotoxicity via inhibition of TNFα-induced apoptosis, 2020, Science Immunology
  • Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes, 2022, Nature Communications

Best Publications

  • CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

    Julian D. Gillmore;Ed Gane;Jorg Taubel;Justin Kao

  • Disruption of overlapping transcripts in the ROSA βgeo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells

    Brian P. Zambrowicz;Akira Imamoto;Steve Fiering;Leonard A. Herzenberg

  • A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease

    Noura S. Abul-Husn;Xiping Cheng;Alexander H. Li;Yurong Xin

  • The knockout mouse project

    Christopher P. Austin;James F. Battey;Allan Bradley;Maja Bucan

  • Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia

    Carol J. Quaife;Seth D. Findley;Jay C. Erickson;Glenda J. Froelick

  • Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

    Brian P. Zambrowicz;Glenn A. Friedrich;Eric C. Buxton;Stan L. Lilleberg

  • Knockouts model the 100 best-selling drugs—will they model the next 100?

    Brian P. Zambrowicz;Arthur T. Sands

  • Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN.

    Dorit B. Donoviel;Deon D. Freed;Hannes Vogel;David G. Potter

  • Lrp5 functions in bone to regulate bone mass

    Yajun Cui;Paul J Niziolek;Paul J Niziolek;Bryan T MacDonald;Cassandra R Zylstra

  • Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles

    Brian A. Masters;Carol J. Quaife;Jay C. Erickson;Edward J. Kelly

  • Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice

    Cynthia J. Guidi;Arthur T. Sands;Brian P. Zambrowicz;Tod K. Turner

  • Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

    Brian P. Zambrowicz;Alejandro Abuin;Ramiro Ramirez-Solis;Lizabeth J. Richter

  • A mouse knockout library for secreted and transmembrane proteins.

    Tracy Tang;Li Li;Jerry Tang;Yun Li

  • Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome.

    Matthew H Kulke;Dieter Hörsch;Martyn E Caplin;Lowell B Anthony

  • Tissue non-specific alkaline phosphatase is expressed in both embryonic and extraembryonic lineages during mouse embryogenesis but is not required for migration of primordial germ cells

    Grant R. MacGregor;Brian P. Zambrowicz;Philippe Soriano

  • mdmx Is a Negative Regulator of p53 Activity in Vivo

    Rick A. Finch;Dorit B. Donoviel;David Potter;Min Shi

  • C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.

    Amanda Atanasio;Vilma Decman;Derek White;Meg Ramos

  • Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice.

    Urvi Desai;E-Chiang Lee;Kyu Chung;Cuihua Gao

  • LX4211 Increases Serum Glucagon-Like Peptide 1 and Peptide YY Levels by Reducing Sodium/Glucose Cotransporter 1 (SGLT1)–Mediated Absorption of Intestinal Glucose

    David R Powell;Melinda Smith;Jennifer Greer;Angela Harris

  • Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice.

    Jinrang Kim;Haruka Okamoto;Zhi Jiang Huang;Guillermo Anguiano

Frequent Co-Authors

Andrew J. Murphy
Andrew J. Murphy St. Jude Children's Research Hospital
Peter Vogel
Peter Vogel St. Jude Children's Research Hospital
Qingyun Liu
Qingyun Liu The University of Texas Health Science Center at Houston
George D. Yancopoulos
George D. Yancopoulos Regeneron (United States)
William C. Olson
William C. Olson Regeneron (United States)
Matthew H. Kulke
Matthew H. Kulke Boston Medical Center
Richard D. Palmiter
Richard D. Palmiter University of Washington
Juan W. Valle
Juan W. Valle University of Manchester
Aris N. Economides
Aris N. Economides Regeneron (United States)
Jesper Gromada
Jesper Gromada Regeneron (United States)

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