World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
39729
World Ranking
4201
National Ranking
2055

Overview

David M. Valenzuela is primarily affiliated with Regeneron in the United States. Their research contributions span multiple disciplines, including Agricultural and Biological Sciences, Neuroscience, and Biochemistry, Genetics and Molecular Biology. The subfields they focus on include Molecular Biology, Materials Chemistry, Plant Science, Forestry, and Food Science.

The main topics covered in Valenzuela's work consist of:

  • Phytochemistry Medicinal Plant Applications
  • Agricultural and Food Sciences
  • Botanical Research and Applications
  • Neurogenesis and neuroplasticity mechanisms
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • CRISPR and Genetic Engineering

Valenzuela's recent publications illustrate a multidisciplinary approach to biological sciences and neuroscience. Their papers include:

  • "Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG," published in 2020 in BMC Biology
  • "Bioactive Compound Profiling and Antioxidant Activity of Phytelephas tenuicaulis and Other Amazonian Fruits," published in 2024 in Foods
  • "Production of large, defined genome modifications in rats by targeting rat embryonic stem cells," published in 2022 in Stem Cell Reports
  • "Strained Graphene as Pristine Graphene with Deformed Momentum Operator," published in 2024 in Preprints.org

The scientist has collaborated frequently with colleagues such as Elena Coyago-Cruz, Aida Guachamin, Gabriela Méndez, Jorge Heredia-Moya, and Edwin Vera. This network of collaborators reflects an interdisciplinary research environment encompassing biological sciences and materials chemistry.

Valenzuela's work has been published across a variety of scientific venues, including Foods, BMC Biology, Stem Cell Reports, and Preprints.org, suggesting engagement with both peer-reviewed journals and preprint platforms. Their research interests range from fundamental neurobiology and molecular mechanisms underlying neuroplasticity to agricultural bioactives and genome editing techniques.

Best Publications

  • Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

    Sue C. Bodine;Esther Latres;Susanne Baumhueter;Venus K.-M. Lai

  • Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

    Raul Mostoslavsky;Katrin F. Chua;Katrin F. Chua;David B. Lombard;Wendy W. Pang

  • Regulation of the Germinal Center Response by MicroRNA-155

    To-Ha Thai;Dinis Pedro Calado;Stefano Casola;K. Mark Ansel

  • Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

    David B. Lombard;Frederick W. Alt;Hwei Ling Cheng;Jakob Bunkenborg

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • CD133 expression is not restricted to stem cells, and both CD133 + and CD133 – metastatic colon cancer cells initiate tumors

    Sergey V. Shmelkov;Jason M. Butler;Andrea T. Hooper;Adilia Hormigo

  • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

    Lauren A. Zenewicz;George D. Yancopoulos;David M. Valenzuela;Andrew J. Murphy

  • The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

    Thomas M DeChiara;David C Bowen;David M Valenzuela;Mary V Simmons

  • Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

    Nicholas W Gale;Sacha J Holland;David M Valenzuela;Ann Flenniken

  • trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

    Stephen P. Squinto;Trevor N. Stitt;Thomas H. Aldrich;Samuel Davis

  • Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation.

    Lauren A. Zenewicz;George D. Yancopoulos;David M. Valenzuela;Andrew J. Murphy

  • Agrin Acts via a MuSK Receptor Complex

    David J Glass;David C Bowen;Trevor N Stitt;Czeslaw Radziejewski

  • The Receptor for Ciliary Neurotrophic Factor

    Samuel Davis;Thomas H. Aldrich;David M. Valenzuela;Vivien Wong

  • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

    Samuel Huber;Nicola Gagliani;Lauren A. Zenewicz;Francis J. Huber

  • High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

    David M Valenzuela;Andrew J Murphy;David Frendewey;Nicholas W Gale

  • Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

    Nicholas W. Gale;Melissa G. Dominguez;Irene Noguera;Li Pan

  • Multiple knockout mouse models reveal lincRNAs are required for life and brain development

    Martin Sauvageau;Martin Sauvageau;Loyal A Goff;Loyal A Goff;Loyal A Goff;Simona Lodato;Simona Lodato;Boyan Bonev;Boyan Bonev

  • During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

    Shenhav Orit Cohen;Jeffrey J. Brault;Steven P. Gygi;David Jonathan Glass

  • Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

    David M. Valenzuela;Jennifer A. Griffiths;Jose Rojas;Thomas H. Aldrich

  • Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

    Tong Jin Zhao;Guosheng Liang;Robert Lin Li;Xuefen Xie

Frequent Co-Authors

George D. Yancopoulos
George D. Yancopoulos Regeneron (United States)
Andrew J. Murphy
Andrew J. Murphy St. Jude Children's Research Hospital
Aris N. Economides
Aris N. Economides Regeneron (United States)
Nicholas W. Gale
Nicholas W. Gale Regeneron (United States)
Richard A. Flavell
Richard A. Flavell Yale University
David J. Glass
David J. Glass Regeneron (United States)
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Raul Mostoslavsky
Raul Mostoslavsky Harvard University
David Artis
David Artis Cornell University
Nancy Y. Ip
Nancy Y. Ip Hong Kong University of Science and Technology

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing David M. Valenzuela

Trending Scientists

Recently Published Articles