Nicholas W. Gale

Overview

Best Publications

• Vascular-specific growth factors and blood vessel formation

  George D. Yancopoulos;Samuel Davis;Nicholas W. Gale;John S. Rudge

  5047
  Citations

• Recognition of single-stranded RNA viruses by Toll-like receptor 7

  Jennifer M. Lund;Lena Alexopoulou;Ayuko Sato;Margaret Karow

  2475
  Citations

• Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

  Ralf H. Adams;George A. Wilkinson;Cornelia Weiss;Francesca Diella

  1329
  Citations

• Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

  Irene Noguera-Troise;Christopher Daly;Nicholas J. Papadopoulos;Sandra Coetzee

  1281
  Citations

• Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

  Nicholas W. Gale;Gavin Thurston;Sean F. Hackett;Roumiana Renard

  1217
  Citations

• CD133 expression is not restricted to stem cells, and both CD133 + and CD133 – metastatic colon cancer cells initiate tumors

  Sergey V. Shmelkov;Jason M. Butler;Andrea T. Hooper;Adilia Hormigo

  1154
  Citations

• Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation.

  Ulrike Fiedler;Yvonne Reiss;Marion Scharpfenecker;Verena Grunow

  1129
  Citations

• Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development

  Nicholas W. Gale;George D. Yancopoulos

  1119
  Citations

• Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

  Nicholas W Gale;Sacha J Holland;David M Valenzuela;Ann Flenniken

  1068
  Citations

• Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

  P. Chardin;J. H. Camonis;N. W. Gale;L. Van Aelst

  1062
  Citations

• Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.

  Samuel Davis;Nicholas W. Gale;Thomas H. Aldrich;Peter C. Maisonpierre

  950
  Citations

• Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting.

  I. B. Lobov;R. A. Renard;N. Papadopoulos;N. W. Gale

  937
  Citations

• EphB receptors interact with NMDA receptors and regulate excitatory synapse formation.

  Matthew B Dalva;Mari A Takasu;Michael Z Lin;Steven M Shamah

  866
  Citations

• High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

  David M Valenzuela;Andrew J Murphy;David Frendewey;Nicholas W Gale

  774
  Citations

• Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

  Nicholas W. Gale;Melissa G. Dominguez;Irene Noguera;Li Pan

  770
  Citations

• Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

  Nicholas W. Gale;Susan Kaplan;Eve J. Lowenstein;Joseph Schlessinger

  745
  Citations

• Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

  Sacha J. Holland;Nicholas W. Gale;Geraldine Mbamalu;George D. Yancopoulos

  661
  Citations

• PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

  Richard Torres;Bonnie L Firestein;Hualing Dong;Jeff Staudinger

  616
  Citations

• Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone

  Joanne C. Conover;Joanne C. Conover;Fiona Doetsch;Jose-Manuel Garcia-Verdugo;Nicholas W. Gale

  603
  Citations

• Generation of functional multipotent adult stem cells from GPR125 + germline progenitors

  Marco Seandel;Marco Seandel;Daylon James;Sergey V. Shmelkov;Ilaria Falciatori

  542
  Citations