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Molecular Biology

D-Index
101
Citations
48209
World Ranking
506
National Ranking
281

Research.com Recognitions

  • 2020 - Member of the National Academy of Sciences

Overview

Dafna Bar-Sagi is affiliated with New York University in the United States. Their research spans several main fields of study, including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Within these areas, they have contributed significantly to subfields such as Oncology, Immunology, Molecular Biology, Cancer Research, and Physiology.

The scientist's work focuses on topics related to cancer, particularly Pancreatic and Hepatic Oncology Research, and the role of immune cells in cancer. Other research themes include Cancer Immunotherapy and Biomarkers, Phagocytosis and Immune Regulation, Immune Cell Function and Interaction, Cancer, Hypoxia, and Metabolism, as well as Cancer Genomics and Diagnostics.

Frequently, Dafna Bar-Sagi has collaborated with several coauthors, including Emily Vucic, Emma Kurz, Cristina Hajdu, Joseph Puccini, and Carolina Alcantara Hirsch.

Their publications appear regularly in key venues such as Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Cell, Nature Cancer, and Cancer Immunology Research.

Selected recent papers authored or coauthored by Dafna Bar-Sagi include:

  • Tumor Cell-Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer, 2020, Cancer Research
  • Embracing cancer complexity: Hallmarks of systemic disease, 2024, Cell
  • Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer, 2022, Cancer Cell
  • Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer, 2020, Cancer Discovery
  • EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion, 2021, Cell

Dafna Bar-Sagi was recognized as a Member of the National Academy of Sciences in 2020.

Best Publications

  • The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

    E.J. Lowenstein;R.J. Daly;A.G. Batzer;W. Li

  • Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

    Cathy Tournier;Patricia M. Hess;Derek D. Yang;Jie Xu

  • RAS oncogenes: weaving a tumorigenic web

    Yuliya Pylayeva-Gupta;Elda Grabocka;Dafna Bar-Sagi

  • Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

    Cosimo Commisso;Shawn M. Davidson;Rengin G. Soydaner-Azeloglu;Seth J. Parker

  • Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

    D. E. Quelle;R. A. Ashmun;S. A. Shurtleff;Jun-Ya Kato

  • Nucleolar Arf sequesters Mdm2 and activates p53.

    Jason D. Weber;Jason D. Weber;Laura J. Taylor;Martine F. Roussel;Charles J. Sherr

  • A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

    H Kouhara;Y.R Hadari;T Spivak-Kroizman;J Schilling

  • Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.

    N. Li;A. Batzer;R. Daly;V. Yajnik

  • Ras and Rho GTPases - A Family Reunion

    Dafna Bar-Sagi;Alan Hall

  • Ras-induced Interleukin-8 expression plays a critical role in tumor growth and angiogenesis

    Anke Sparmann;Dafna Bar-Sagi

  • Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

    P. Chardin;J. H. Camonis;N. W. Gale;L. Van Aelst

  • Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

    Dafna Bar-Sagi;James R. Feramisco

  • The structural basis of the activation of Ras by Sos

    P.A Boriack-Sjodin;S.M Margarit;D Bar-Sagi;J. Kuriyan

  • Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins

    Dafna Bar-Sagi;James R. Feramisco

  • Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein

    Jurre J. Kamphorst;Michel Nofal;Cosimo Commisso;Sean R. Hackett

  • Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

    William C. Colley;Tsung-Chang Sung;Richard Roll;John Jenco

  • Redox-dependent downregulation of Rho by Rac

    Anjaruwee S. Nimnual;Laura J. Taylor;Dafna Bar-Sagi

  • Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

    Nicholas W. Gale;Susan Kaplan;Eve J. Lowenstein;Joseph Schlessinger

  • Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia

    Yuliya Pylayeva-Gupta;Kyoung Eun Lee;Cristina H. Hajdu;George Miller

  • Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

    Anjaruwee S. Nimnual;Bogdan A. Yatsula;Dafna Bar-Sagi

Frequent Co-Authors

John Kuriyan
John Kuriyan Vanderbilt University
Holger Sondermann
Holger Sondermann Kiel University
Joseph Schlessinger
Joseph Schlessinger Yale University
Mark R. Philips
Mark R. Philips New York University
Joshua D. Rabinowitz
Joshua D. Rabinowitz Princeton University
Michael L. Dustin
Michael L. Dustin University of Oxford
Michael W. Epperly
Michael W. Epperly University of Pittsburgh
Len A. Pennacchio
Len A. Pennacchio Lawrence Berkeley National Laboratory
Bruno Dallapiccola
Bruno Dallapiccola Bambino Gesù Children's Hospital

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