World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
32530
World Ranking
2422
National Ranking
1285

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Michael A. Frohman is affiliated with Stony Brook University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on Molecular Biology, Cancer Research, Oncology, Genetics, and Epidemiology.

The scientist's recent work includes studies on enzyme structure and function, lipid metabolism, mitochondrial function, and cancer-related biochemical processes.

  • Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2 and RhoA (2020), Nature Chemical Biology
  • Structure and regulation of human phospholipase D (2021), Advances in Biological Regulation
  • Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy (2021), Journal of Clinical Investigation
  • Roles for Phospholipase D1 in the Tumor Microenvironment (2020), Advances in experimental medicine and biology
  • Inhibition of phospholipase D1 reduces pancreatic carcinogenesis in mice partly through a FAK-dependent mechanism (2024), Carcinogenesis

Frequent coauthors include Forrest Z. Bowling, Michael V. Airola, Christian Salazar, Justin A. Bell, and Tahrima Saiha Huq.

Their publications have appeared in the following venues:

  • Nature Chemical Biology
  • Advances in Biological Regulation
  • Journal of Clinical Investigation
  • Advances in experimental medicine and biology
  • Carcinogenesis

Michael A. Frohman has also contributed to books published by Springer Science+Business Media, including Pharmacology of Immunosuppression (2022) and Lipid Signaling in Human Diseases (2020).

Their main research topics encompass:

  • Mitochondrial Function and Pathology
  • Lipid metabolism and biosynthesis
  • Cancer, Lipids, and Metabolism
  • Bone health and treatments
  • Enzyme Structure and Function
  • Biochemical and Molecular Research
  • Protein Kinase Regulation and GTPase Signaling

Michael A. Frohman has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2015 and is a member of the Association of American Physicians.

Best Publications

  • Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer

    Michael A. Frohman;Michael K. Dush;Gail R. Martin

  • REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

    Jayhong A Chong;José Tapia-Ramirez;Sandra Kim;Juan J Toledo-Aral

  • Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation

    Akira Honda;Masahiro Nogami;Takeaki Yokozeki;Masakazu Yamazaki

  • Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

    William C. Colley;Tsung-Chang Sung;Richard Roll;John Jenco

  • Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries

    A. Bulfone;L. Puelles;M. H. Porteus;M. A. Frohman

  • Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

    Scott M. Hammond;Yelena M. Altshuller;Tsung Chang Sung;Simon A. Rudge

  • Characterization of Two Alternately Spliced Forms of Phospholipase D1 ACTIVATION OF THE PURIFIED ENZYMES BY PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE, ADP-RIBOSYLATION FACTOR, AND RHO FAMILY MONOMERIC GTP-BINDING PROTEINS AND PROTEIN KINASE C-α

    Scott M. Hammond;John M. Jenco;Shigeru Nakashima;Karen Cadwallader

  • Rapid amplification of complementary DNA ends for generation of full-length complementary DNAs: thermal RACE.

    Michael A. Frohman

  • Phospholipase D: a lipid centric review.

    G. M. Jenkins;M. A. Frohman

  • A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis

    Seok-Yong Choi;Ping Huang;Gary M. Jenkins;David C. Chan

  • 3′ End cDNA amplification using classic RACE

    Elizabeth Scotto-Lavino;Guangwei Du;Michael A Frohman

  • 5′ end cDNA amplification using classic RACE

    Elizabeth Scotto–Lavino;Guangwei Du;Michael A Frohman

  • Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.

    Tsung Chang Sung;Rachel L. Roper;Yue Zhang;Simon A. Rudge

  • Phospholipase D and Its Product, Phosphatidic Acid, Mediate Agonist-dependent Raf-1 Translocation to the Plasma Membrane and the Activation of the Mitogen-activated Protein Kinase Pathway

    Megan A. Rizzo;Kuntala Shome;Chandrasekaran Vasudevan;Donna B. Stolz

  • Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos

    Chen Zhao;Guangwei Du;Karl Skowronek;Michael A. Frohman

  • Mammalian phospholipase D structure and regulation.

    Michael A Frohman;Tsung-Chang Sung;Andrew J Morris

  • Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm.

    M.A. Frohman;M. Boyle;G.R. Martin

  • Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

    Ye Guang Chen;Anirban Siddhanta;Cary D. Austin;Scott M. Hammond

  • piRNA-associated germline nuage formation and spermatogenesis require MitoPLD profusogenic mitochondrial-surface lipid signaling.

    Huiyan Huang;Qun Gao;Xiaoxue Peng;Seok Yong Choi;Seok Yong Choi

  • Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

    Akihiko Nishikimi;Hideo Fukuhara;Wenjuan Su;Tsunaki Hongu

Frequent Co-Authors

Andrew J. Morris
Andrew J. Morris University of Kentucky
Yasunori Kanaho
Yasunori Kanaho University of Tsukuba
Gail R. Martin
Gail R. Martin University of California, San Francisco
Sylvette Chasserot-Golaz
Sylvette Chasserot-Golaz Centre national de la recherche scientifique, CNRS
Takehiko Sasaki
Takehiko Sasaki Tokyo Medical and Dental University
Marie-France Bader
Marie-France Bader Centre national de la recherche scientifique, CNRS
Nicolas Vitale
Nicolas Vitale Centre national de la recherche scientifique, CNRS
Gilbert Di Paolo
Gilbert Di Paolo Columbia University Medical Center
Glenn D. Prestwich
Glenn D. Prestwich University of Utah
William N. Kelley
William N. Kelley University of Pennsylvania

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