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Biology and Biochemistry

D-Index
76
Citations
31083
World Ranking
4940
National Ranking
2372

Overview

Gilbert Di Paolo is affiliated with Columbia University Medical Center in the United States and focuses primarily on research within the field of medicine. Their work prominently addresses neurological conditions, with a strong emphasis on neuroinflammation and neurodegeneration mechanisms.

The scientist's research spans several specialized subfields including neurology, physiology, immunology, cell biology, and molecular biology. These subfields reflect the complexity and multidisciplinary nature of the disorders they investigate.

The main topics researched by Gilbert Di Paolo include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Lysosomal Storage Disorders Research
  • Amyotrophic Lateral Sclerosis Research
  • Cellular transport and secretion
  • Inflammation biomarkers and pathways

Gilbert Di Paolo has contributed to a number of scientific publications. Recent notable papers include:

  • "TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge" (2020), published in Neuron
  • "Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region" (2020), published in EMBO Molecular Medicine
  • "Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia" (2020), published in Nature Neuroscience
  • "Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer's Disease" (2020), published in Neuron
  • "A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models" (2023), published in Nature Neuroscience

Frequent coauthors of Gilbert Di Paolo include:

  • Joseph W. Lewcock
  • Sonnet S. Davis
  • Jung H. Suh
  • Kathryn M. Monroe
  • Thomas Sandmann

The publication venues where Gilbert Di Paolo frequently publishes are diverse, with a concentration in notable journals and repositories. These include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Annals of Oncology
  • Neuron
  • Nature Neuroscience
  • Cell

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Phosphoinositides in cell regulation and membrane dynamics

    Gilbert Di Paolo;Pietro De Camilli

  • Linking lipids to Alzheimer's disease: cholesterol and beyond

    Gilbert Di Paolo;Tae-Wan Kim

  • Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling

    Ottavio Cremona;Ottavio Cremona;Gilbert Di Paolo;Markus R Wenk;Anita Lüthi

  • Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.

    Robin B. Chan;Tiago Gil Oliveira;Etty P. Cortes;Lawrence S. Honig

  • Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

    Jessica W. Wu;Mathieu Herman;Li Liu;Sabrina Simoes

  • Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin

    Gilbert Di Paolo;Lorenzo Pellegrini;Lorenzo Pellegrini;Kresimir Letinic;Gianluca Cestra

  • TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.

    Alicia A. Nugent;Karin Lin;Bettina van Lengerich;Steve Lianoglou

  • Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking.

    Gilbert Di Paolo;Howard S. Moskowitz;Keith Gipson;Markus R. Wenk

  • Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis.

    Niels Ringstad;Helge Gad;Peter Löw;Gilbert Di Paolo

  • Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin.

    Helge Gad;Niels Ringstad;Peter Löw;Ole Kjaerulff

  • The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures.

    Catharine E. Krebs;Siamak Karkheiran;James C. Powell;Mian Cao

  • The Role of Lipids in the Control of Autophagy

    Claudia Dall'Armi;Kelly A. Devereaux;Gilbert Di Paolo

  • Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry

    Markus R Wenk;Louise Lucast;Gilbert Di Paolo;Anthony J Romanelli

  • Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells

    Bohao Liu;Benjamin W. Lee;Koki Nakanishi;Aranzazu Villasante

  • Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice

    Gilbert Di Paolo;Sethuraman Sankaranarayanan;Markus R. Wenk;Laurie Daniell

  • PIP Kinase Iγ Is the Major PI(4,5)P2 Synthesizing Enzyme at the Synapse

    Markus R Wenk;Lorenzo Pellegrini;Vadim A Klenchin;Gilbert Di Paolo

  • The Dual Phosphatase Activity of Synaptojanin1 Is Required for Both Efficient Synaptic Vesicle Endocytosis and Reavailability at Nerve Terminals

    Meera Mani;Sang Yoon Lee;Louise Lucast;Ottavio Cremona;Ottavio Cremona

  • Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

    Diego E Berman;Claudia Dall'Armi;Sergey V Voronov;Laura Beth J McIntire

  • Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10

    Beat M. Riederer;Véronique Pellier;Bruno Antonsson;Gilbert Di Paolo

Frequent Co-Authors

Pietro De Camilli
Pietro De Camilli Yale University
Markus R. Wenk
Markus R. Wenk Hamad bin Khalifa University
Karen Duff
Karen Duff University College London
Giuseppe Astarita
Giuseppe Astarita Georgetown University
Ottavio Arancio
Ottavio Arancio Columbia University
Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Ryan J. Watts
Ryan J. Watts Denali Therapeutics (United States)
Do Sik Min
Do Sik Min Yonsei University
Michael A. Frohman
Michael A. Frohman Stony Brook University
Guanghou Shui
Guanghou Shui Chinese Academy of Sciences

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