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Neuroscience

D-Index
89
Citations
35223
World Ranking
1137
National Ranking
589

Overview

Ottavio Arancio is affiliated with Columbia University in the United States and specializes in research spanning medicine, biochemistry, genetics, molecular biology, and neuroscience. Their work focuses on critical areas including Alzheimer's disease research and treatments, neuroscience and neuropharmacology research, neuroinflammation and neurodegeneration mechanisms, and the study of cholinesterase in neurodegenerative diseases.

Their research is further detailed through subfields such as molecular biology, physiology, cellular and molecular neuroscience, neurology, and pharmacology, underpinning a broad interdisciplinary approach to understanding brain function and pathology.

Ottavio Arancio has contributed extensively to scientific literature, including notable recent publications:

  • Involvement of p38 MAPK in Synaptic Function and Dysfunction, 2020, International Journal of Molecular Sciences
  • Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer's disease, 2020, Biochemical Pharmacology
  • Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease, 2022, Brain
  • Alzheimer's disease as an autoimmune disorder of innate immunity endogenously modulated by tryptophan metabolites, 2022, Alzheimer s & Dementia Translational Research & Clinical Interventions
  • Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2, 2023, Nature Neuroscience

These publications reflect an emphasis on molecular pathways involved in synaptic function and dysfunction, therapeutic strategies targeting phosphodiesterase enzymes for Alzheimer's disease, and mechanisms contributing to neurodegenerative processes, including the role of extracellular vesicles and immune modulation.

Frequent coauthors collaborating with Ottavio Arancio include:

  • Elentina K. Argyrousi
  • Erica Acquarone
  • Agnieszka Staniszewski
  • Elisa Zuccarello
  • Jole Fiorito

Their research output is published predominantly in journals such as Alzheimer s & Dementia, bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, Brain, and Alzheimer s & Dementia Translational Research & Clinical Interventions, indicating a strong presence in Alzheimer's and neuroscience-focused academic communities.

Main topics addressed in Ottavio Arancio's work include:

  • Alzheimer's disease research and treatments
  • Neuroscience and Neuropharmacology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cholinesterase and Neurodegenerative Diseases
  • Phosphodiesterase function and regulation
  • Computational Drug Discovery Methods
  • Extracellular vesicles in disease

The combination of diverse research topics, frequent collaboration patterns, and publication record highlights a comprehensive scientific inquiry into neurological disorders, with particular emphasis on molecular mechanisms and therapeutic developments in Alzheimer's disease and related neurodegenerative conditions.

Best Publications

  • Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

    Luca Santarelli;Michael Saxe;Cornelius Gross;Alexandre Surget

  • ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

    Joyce W. Lustbader;Maurizio Cirilli;Chang Lin;Hong Wei Xu;Hong Wei Xu

  • Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

    Guomei Tang;Kathryn Gudsnuk;Sheng-Han Kuo;Marisa L. Cotrina;Marisa L. Cotrina

  • Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.

    Thomas J. O'dell;Robert D. Hawkins;Eric R. Kandel;Ottavio Arancio

  • Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.

    Heng Du;Lan Guo;Fang Fang;Doris Chen

  • Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus.

    Daniela Puzzo;Lucia Privitera;Elena Leznik;Mauro Fà

  • Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

    Mychael V. Lourenco;Mychael V. Lourenco;Rudimar L. Frozza;Rudimar L. Frozza;Guilherme B. de Freitas;Guilherme B. de Freitas;Hong Zhang

  • Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

    Ottavio V. Vitolo;Antonino Sant'Angelo;Vincenzo Costanzo;Fortunato Battaglia

  • Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome

    Paolo Moretti;Jonathan M. Levenson;Fortunato Battaglia;Richard Atkinson

  • Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

    Bing Gong;Ottavio V. Vitolo;Fabrizio Trinchese;Shumin Liu

  • Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

    Fabrizio Trinchese;Shumin Liu;Shumin Liu;Fortunato Battaglia;Fortunato Battaglia;Sean Walter;Sean Walter

  • Ubiquitin Hydrolase Uch-L1 Rescues β-Amyloid-Induced Decreases in Synaptic Function and Contextual Memory

    Bing Gong;Zixuan Cao;Ping Zheng;Ottavio V. Vitolo

  • NITRIC OXIDE ACTS DIRECTLY IN THE PRESYNAPTIC NEURON TO PRODUCE LONG-TERM POTENTIATION IN CULTURED HIPPOCAMPAL NEURONS

    Ottavio Arancio;Michael Kiebler;C.Justin Lee;Varda Lev-Ram

  • Activity-dependent long-term enhancement of transmitter release by presynaptic 3',5'-cyclic GMP in cultured hippocampal neurons

    Arancio O;Kandel Er;Hawkins Rd

  • RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice

    Ottavio Arancio;Hui Ping Zhang;Xi Chen;Chang Lin

  • Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus.

    Robert D. Hawkins;Hyeon Son;Ottavio Arancio

  • Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

    Yitshak I. Francis;Mauro Fà;Haider Ashraf;Hong Zhang

  • Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory.

    Daniela Puzzo;Lucia Privitera;Lucia Privitera;Mauro Fa;Agnieszka Staniszewski

  • Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid-β Load in an Alzheimer's Disease Mouse Model

    Daniela Puzzo;Agnieszka Staniszewski;Shi Xian Deng;Lucia Privitera

  • ABAD enhances Aβ-induced cell stress via mitochondrial dysfunction

    Kazuhiro Takuma;Jun Yao;Jianmin Huang;Hongwei Xu

Frequent Co-Authors

Daniela Puzzo
Daniela Puzzo University of Catania
Luciano Domenici
Luciano Domenici University of L'Aquila
Eric R. Kandel
Eric R. Kandel Columbia University
Claudio Grassi
Claudio Grassi Catholic University of the Sacred Heart
Robert D. Hawkins
Robert D. Hawkins Columbia University
Linda J. Van Eldik
Linda J. Van Eldik University of Kentucky
Fortunato Battaglia
Fortunato Battaglia Seton Hall University
Balapal S. Basavarajappa
Balapal S. Basavarajappa Nathan Kline Institute for Psychiatric Research
Ralph A. Nixon
Ralph A. Nixon Nathan Kline Institute for Psychiatric Research
Karen Duff
Karen Duff University College London

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