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Neuroscience

D-Index
82
Citations
31172
World Ranking
1491
National Ranking
742

Overview

Linda J. Van Eldik is affiliated with the University of Kentucky in the United States. Their research primarily focuses on medicine, with significant contributions in neurology, physiology, psychiatry and mental health, molecular biology, and immunology. The scientist has published extensively on topics related to neurodegenerative disorders, particularly Alzheimer's disease and dementia.

Their main research themes include:

  • Alzheimer's disease research and treatments
  • Dementia and Cognitive Impairment Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cholinesterase and Neurodegenerative Diseases
  • Neurological Disease Mechanisms and Treatments
  • S100 Proteins and Annexins
  • Traumatic Brain Injury and Neurovascular Disturbances

Frequent publication venues for Van Eldik include:

  • Alzheimer's & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica Communications
  • Journal of Neuroinflammation
  • Journal of Neuropathology & Experimental Neurology

The scientist has collaborated frequently with several peers, including:

  • Gregory A. Jicha
  • Erin L. Abner
  • Peter T. Nelson
  • Frederick A. Schmitt
  • Donna M. Wilcock

Recent papers authored by Van Eldik highlight a range of neurodegenerative research:

  • "Prevalence and Clinical Phenotype of Quadruple Misfolded Proteins in Older Adults," 2020, JAMA Neurology
  • "Brain arteriolosclerosis," 2020, Acta Neuropathologica
  • "Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice," 2020, Journal of Neuroinflammation
  • "Neurodegenerative pathologies associated with behavioral and psychological symptoms of dementia in a community-based autopsy cohort," 2023, Acta Neuropathologica Communications
  • "The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review," 2020, Experimental Neurology

Best Publications

  • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

    Holly Oakley;Sarah L. Cole;Sreemathi Logan;Erika Maus

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.

    Scott J Webster;Adam D Bachstetter;Peter T Nelson;Frederick A Schmitt

  • β-Amyloid Stimulation of Inducible Nitric-oxide Synthase in Astrocytes Is Interleukin-1β- and Tumor Necrosis Factor-α (TNFα)-dependent, and Involves a TNFα Receptor-associated Factor- and NFκB-inducing Kinase-dependent Signaling Mechanism *

    Keith T. Akama;Linda J. Van Eldik

  • S100β Induces Neuronal Cell Death Through Nitric Oxide Release from Astrocytes

    Jingru Hu;Adriana Ferreira;Linda J. Van Eldik

  • Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

    Eric M Reiman;Joseph F Arboleda-Velasquez;Yakeel T Quiroz;Matthew J Huentelman

  • Alzheimer’s disease is not “brain aging”: neuropathological, genetic, and epidemiological human studies

    Peter T. Nelson;Elizabeth Head;Frederick A. Schmitt;Paulina R. Davis

  • In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

    Jin G. Sheng;Kazuhiro Ito;Robert D. Skinner;Robert E. Mrak

  • Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

    Jennifer L. Furman;Diana M. Sama;John C. Gant;Tina L. Beckett

  • A novel Alzheimer disease locus located near the gene encoding tau protein

    G. Jun;C. A. Ibrahim-Verbaas;M. Vronskaya;J-C Lambert;J-C Lambert;J-C Lambert

  • S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes.

    Jingru Hu;Francis Castets;José L. Guevara;Linda J. Van Eldik

  • A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model

    Lenka Munoz;Lenka Munoz;Hantamalala Ralay Ranaivo;Saktimayee M Roy;Wenhui Hu;Wenhui Hu

  • Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ).

    Adam D Bachstetter;Bin Xing;Lucia de Almeida;Edgardo R Dimayuga

  • Hippocampal sclerosis in advanced age: clinical and pathological features

    Peter T. Nelson;Frederick A. Schmitt;Yushun Lin;Erin L. Abner

  • Lipoproteins in the Central Nervous System

    Mary Jo Ladu;Catherine Reardon;Linda Van Eldik;Anne M. Fagan

  • Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging

    Adam D Bachstetter;Linda J Van Eldik;Frederick A Schmitt;Janna H Neltner

  • Brain arteriolosclerosis

    Unknown

  • Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

    Brian W. Kunkle;Michael Schmidt;Hans Ulrich Klein;Adam C. Naj

  • The roles of inflammation and immune mechanisms in Alzheimer's disease.

    Linda J. Van Eldik;Maria C. Carrillo;Patricia E. Cole;Dominik Feuerbach

  • University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology.

    Frederick A. Schmitt;Peter T. Nelson;Erin Abner;Stephen Scheff

  • Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

    Hantamalala Ralay Ranaivo;Jeffrey M. Craft;Wenhui Hu;Ling Guo

  • Self-reported memory complaints Implications from a longitudinal cohort with autopsies

    Richard J. Kryscio;Erin L. Abner;Gregory E. Cooper;David W. Fardo

  • Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.

    Adam C. Naj;Gyungah Jun;Christiane Reitz;Brian W. Kunkle

  • Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease

    Peter T. Nelson;Charles D. Smith;Erin L. Abner;Bernard J. Wilfred

Frequent Co-Authors

Adam D. Bachstetter
Adam D. Bachstetter University of Kentucky
Philip L. De Jager
Philip L. De Jager Columbia University
Ottavio Arancio
Ottavio Arancio Columbia University
Jeffrey Kaye
Jeffrey Kaye Oregon Health & Science University
Liana G. Apostolova
Liana G. Apostolova Indiana University
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Lindsay A. Farrer
Lindsay A. Farrer Boston University
Gerard D. Schellenberg
Gerard D. Schellenberg University of Pennsylvania
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Margaret A. Pericak-Vance
Margaret A. Pericak-Vance University of Miami

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