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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
16279
World Ranking
11786
National Ranking
5068

Overview

Lawrence C. Sowers is affiliated with The University of Texas Medical Branch at Galveston in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a significant emphasis on Molecular Biology.

The main topics covered in their work include DNA Repair Mechanisms, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, DNA and Nucleic Acid Chemistry, Genetics and Neurodevelopmental Disorders, CRISPR and Genetic Engineering, and Advanced Biosensing and Bioanalysis Techniques.

Frequent publication venues where their research appears include Neuro-Oncology, Molecules, Chemical Research in Toxicology, UNC Libraries, and the International Journal of Molecular Sciences.

Some of their recent papers are:

  • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification (2020, UNC Libraries)
  • Glioblastoma and Methionine Addiction (2022, International Journal of Molecular Sciences)
  • Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming (2022, PLoS ONE)
  • A combinatorial system to examine the enzymatic repair of multiply damaged DNA substrates (2022, Nucleic Acids Research)
  • DNA Base Excision Repair Intermediates Influence Duplex-Quadruplex Equilibrium (2023, Molecules)

Frequent coauthors collaborating with Lawrence C. Sowers include:

  • Mark L. Sowers
  • Jason Herring
  • Tuvshintugs Baljinnyam
  • Linda C. Hackfeld
  • James W. Conrad

Best Publications

  • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

    Shinsuke Ito;Ana C. D’Alessio;Ana C. D’Alessio;Olena V. Taranova;Olena V. Taranova;Kwonho Hong;Kwonho Hong

  • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR.

    Haibo Wang;Jasmine Chen;Kevin Hollister;Lawrence C Sowers

  • Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)

    Victoria Valinluck;Hsin-Hao Tsai;Daniel K. Rogstad;Artur Burdzy

  • Endogenous Cytosine Damage Products Alter the Site Selectivity of Human DNA Maintenance Methyltransferase DNMT1

    Victoria Valinluck;Lawrence C. Sowers

  • Comparison between DNA melting thermodynamics and DNA polymerase fidelity.

    John Petruska;Myron F. Goodman;Michael S. Boosalis;Lawrence C. Sowers

  • Base pairing and mutagenesis: observation of a protonated base pair between 2-aminopurine and cytosine in an oligonucleotide by proton NMR.

    Lawrence Sowers;G. V. Fazakerley;R. Eritja;B. E. Kaplan

  • Dynamics of mismatched base pairs in DNA.

    Christopher R. Guest;Remo A. Hochstrasser;Remo A. Hochstrasser;Lawrence C. Sowers;Lawrence C. Sowers;David P. Millar;David P. Millar

  • Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA

    Daniel I. Feig;Lawrence C. Sowers;Lawrence A. Loeb

  • First Principles Calculation of pKa Values for 5-Substituted Uracils

    Yun Hee Jang;Lawrence C. Sowers;Tahir Çağin;William A. Goddard

  • pKa Values of Guanine in Water: Density Functional Theory Calculations Combined with Poisson-Boltzmann Continuum-Solvation Model

    Yun Hee Jang;William A. Goddard;Katherine T. Noyes;Lawrence C. Sowers

  • The abasic site as a challenge to DNA polymerase: A nuclear magnetic resonance study of G, C and T opposite a model abasic site

    Ph Cuniasse;G. V. Fazakerley;W. Guschlbauer;B. E. Kaplan

  • Comparison of nucleotide interactions in water, proteins, and vacuum: Model for DNA polymerase fidelity

    J. Petruska;Lawrence Sowers;M. F. Goodman

  • Mechanism of human methyl-directed DNA methyltransferase and the fidelity of cytosine methylation.

    Steven S. Smith;Bruce E. Kaplan;Lawrence C. Sowers;Edward M. Newman

  • Inflammation-mediated cytosine damage: A mechanistic link between inflammation and the epigenetic alterations in human cancers

    Victoria Valinluck;Lawrence C. Sowers

  • The nucleotide analog 2-aminopurine as a spectroscopic probe of nucleotide incorporation by the Klenow fragment of Escherichia coli polymerase I and bacteriophage T4 DNA polymerase.

    Michelle West Frey;Lawrence C. Sowers;David P. Millar;Stephen J. Benkovic

  • Metabolism and anti-human immunodeficiency virus-1 activity of 2-halo-2',3'-dideoxyadenosine derivatives.

    T. Haertle;C. J. Carrera;D. B. Wasson;Lawrence Sowers

  • A fluorescence-based assay for monitoring helicase activity.

    Kevin D. Raney;Lawrence C. Sowers;David P. Millar;Stephen J. Benkovic

  • Molecular basis of cisplatin resistance in human carcinomas: model systems and patients.

    K. J. Scanlon;M. Kashani-Sabet;H. Miyachi;Lawrence Sowers

  • Base stacking and molecular polarizability: Effect of a methyl group in the 5-position of pyrimidines

    Lawrence C. Sowers;Barbara Ramsay Shaw;W.David Sedwick

  • DNA base modification: ionized base pairs and mutagenesis

    Lawrence C. Sowers;Barbara Ramsay Shaw;Martina L. Veigl;W. David Sedwick

Frequent Co-Authors

Myron F. Goodman
Myron F. Goodman University of Southern California
Ramon Eritja
Ramon Eritja Spanish National Research Council
William A. Goddard
William A. Goddard California Institute of Technology
David P. Millar
David P. Millar Scripps Research Institute
Allan R. Brasier
Allan R. Brasier University of Wisconsin–Madison
Adrian Bird
Adrian Bird University of Edinburgh
Stephen J. Benkovic
Stephen J. Benkovic Pennsylvania State University
Ping Wu
Ping Wu The University of Texas Medical Branch at Galveston
Jiping Tang
Jiping Tang Loma Linda University
Tahir Cagin
Tahir Cagin Texas A&M University

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