Roberto Pellicciari

Overview

Best Publications

• TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

  Charles W. Thomas;Antimo Gioiello;Lilia G Noriega;Lilia G Noriega;Axelle Strehle

  2003
  Citations

• Targeting bile-acid signalling for metabolic diseases

  Charles Thomas;Roberto Pellicciari;Mark Pruzanski;Johan Auwerx

  1564
  Citations

• 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

  Roberto Pellicciari;Stefano Fiorucci;Emidio Camaioni;Carlo Clerici

  868
  Citations

• Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities

  Robert Schwarcz;Roberto Pellicciari

  780
  Citations

• TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.

  Thijs Pols;Mitsunori Nomura;Taoufiq Harach;Giuseppe Lo Sasso

  616
  Citations

• Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

  Elisabet Wahlberg;Tobias Karlberg;Ekaterina Kouznetsova;Ekaterina Kouznetsova;Natalia Markova;Natalia Markova

  542
  Citations

• The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis

  Stefano Fiorucci;Elisabetta Antonelli;Giovanni Rizzo;Barbara Renga

  522
  Citations

• De novo NAD + synthesis enhances mitochondrial function and improves health

  Elena Katsyuba;Adrienne Mottis;Marika Zietak;Marika Zietak;Francesca De Franco

  434
  Citations

• Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

  Li Zhi Mi;Srikripa Devarakonda;Joel M. Harp;Qing Han

  360
  Citations

• Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

  Giovanni Sorrentino;Alessia Perino;Ece Yildiz;Gaby El Alam

  357
  Citations

• Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

  Hiroyuki Sato;Antonio Macchiarulo;Charles Thomas;Antimo Gioiello

  339
  Citations

• Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure−Activity Relationship of a Series of Body and Side Chain Modified Analogues of Chenodeoxycholic Acid

  Roberto Pellicciari;Gabriele Costantino;Emidio Camaioni;Bahman M. Sadeghpour

  298
  Citations

• Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

  Roberto Pellicciari;Antimo Gioiello;Antonio Macchiarulo;Charles Thomas;Charles Thomas

  274
  Citations

• Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid x receptor ligand, in estrogen-induced cholestasis

  Stefano Fiorucci;Carlo Clerici;Elisabetta Antonelli;Stefano Orlandi

  270
  Citations

• A Farnesoid X Receptor-Small Heterodimer Partner Regulatory Cascade Modulates Tissue Metalloproteinase Inhibitor-1 and Matrix Metalloprotease Expression in Hepatic Stellate Cells and Promotes Resolution of Liver Fibrosis

  Stefano Fiorucci;Giovanni Rizzo;Elisabetta Antonelli;Barbara Renga

  248
  Citations

• Cross-Talk between Farnesoid-X-Receptor (FXR) and Peroxisome Proliferator-Activated Receptor γ Contributes to the Antifibrotic Activity of FXR Ligands in Rodent Models of Liver Cirrhosis

  Stefano Fiorucci;Giovanni Rizzo;Elisabetta Antonelli;Barbara Renga

  238
  Citations

• TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

  Alessia Perino;Thijs Willem Hendrik Pols;Mitsunori Nomura;Sokrates Stein

  229
  Citations

• Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities

  R. Carpenedo;A. Chiarugi;P. Russi;G. Lombardi

  222
  Citations

• Pharmacological Characterization of 1-Aminoindan-1,5-dicarboxylic Acid, a Potent mGluR1 Antagonist

  Flavio Moroni;Grazia Lombardi;Christian Thomsen;Patrizia Leonardi

  219
  Citations

• The farnesoid X receptor promotes adipocyte differentiation and regulates adipose cell function in vivo.

  Giovanni Rizzo;Moises Disante;Andrea Mencarelli;Barbara Renga

  199
  Citations

• 1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.

  Roberto Pellicciari;Roberto Luneia;Gabriele Costantino;Maura Marinozzi

  198
  Citations