Roberto Pellicciari mostly deals with Biochemistry, Internal medicine, Kynurenic acid, Endocrinology and Pharmacology. His Biochemistry study frequently draws parallels with other fields, such as Cell biology. In his study, which falls under the umbrella issue of Internal medicine, Bile acid, Small heterodimer partner, Retinoid X receptor and Adipogenesis is strongly linked to Farnesoid X receptor.
His Bile acid study frequently links to other fields, such as Stereochemistry. The concepts of his Kynurenic acid study are interwoven with issues in Quinolinic acid, Kynurenine pathway, Kynurenine and Indoleamine 2,3-dioxygenase. His Pharmacology study combines topics from a wide range of disciplines, such as Glutamate receptor, Metabotropic glutamate receptor 1 and Metabotropic glutamate receptor.
His main research concerns Stereochemistry, Biochemistry, Organic chemistry, Bile acid and Metabotropic glutamate receptor. Roberto Pellicciari has included themes like Agonist, Glycine, NMDA receptor and Chemical synthesis in his Stereochemistry study. In general Bile acid, his work in G protein-coupled bile acid receptor is often linked to Side chain linking many areas of study.
His Metabotropic glutamate receptor research is multidisciplinary, incorporating elements of Antagonist and Metabotropic receptor. His research investigates the connection with Kynurenic acid and areas like Quinolinic acid which intersect with concerns in Kynurenine. His Farnesoid X receptor study combines topics in areas such as Internal medicine and Chenodeoxycholic acid.
Roberto Pellicciari focuses on Biochemistry, Bile acid, Receptor, Stereochemistry and Farnesoid X receptor. His Biochemistry study frequently draws connections between adjacent fields such as In vivo. Roberto Pellicciari focuses mostly in the field of Bile acid, narrowing it down to topics relating to Cholestasis and, in certain cases, Metabolism.
Many of his studies on Stereochemistry involve topics that are commonly interrelated, such as Structure–activity relationship. His Farnesoid X receptor research is multidisciplinary, incorporating perspectives in Chenodeoxycholic acid, Ligand, Transactivation, Biological activity and Allosteric regulation. His work deals with themes such as Combinatorial chemistry and Signal transduction, Cell biology, which intersect with G protein-coupled bile acid receptor.
His primary scientific interests are in Biochemistry, G protein-coupled bile acid receptor, Farnesoid X receptor, Stereochemistry and Receptor. His study on G protein-coupled bile acid receptor also encompasses disciplines like
His Stereochemistry research is multidisciplinary, relying on both Agonist, Potency and Transactivation. His studies deal with areas such as Homology modeling and Site-directed mutagenesis as well as Receptor. Chenodeoxycholic acid is the focus of his Bile acid research.
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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles W. Thomas;Antimo Gioiello;Lilia G Noriega;Lilia G Noriega;Axelle Strehle.
Cell Metabolism (2009)
Targeting bile-acid signalling for metabolic diseases
Charles Thomas;Roberto Pellicciari;Mark Pruzanski;Johan Auwerx.
Nature Reviews Drug Discovery (2008)
Manipulation of Brain Kynurenines: Glial Targets, Neuronal Effects, and Clinical Opportunities
Robert Schwarcz;Roberto Pellicciari.
Journal of Pharmacology and Experimental Therapeutics (2002)
Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Elisabet Wahlberg;Tobias Karlberg;Ekaterina Kouznetsova;Ekaterina Kouznetsova;Natalia Markova;Natalia Markova.
Nature Biotechnology (2012)
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
Stefano Fiorucci;Elisabetta Antonelli;Giovanni Rizzo;Barbara Renga.
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.
Thijs Pols;Mitsunori Nomura;Taoufiq Harach;Giuseppe Lo Sasso.
Cell Metabolism (2011)
Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Li Zhi Mi;Srikripa Devarakonda;Joel M. Harp;Qing Han.
Molecular Cell (2003)
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies
Hiroyuki Sato;Antonio Macchiarulo;Charles Thomas;Antimo Gioiello.
Journal of Medicinal Chemistry (2008)
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure−Activity Relationship of a Series of Body and Side Chain Modified Analogues of Chenodeoxycholic Acid
Roberto Pellicciari;Gabriele Costantino;Emidio Camaioni;Bahman M. Sadeghpour.
Journal of Medicinal Chemistry (2004)
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid x receptor ligand, in estrogen-induced cholestasis
Stefano Fiorucci;Carlo Clerici;Elisabetta Antonelli;Stefano Orlandi.
Journal of Pharmacology and Experimental Therapeutics (2005)
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