World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
24839
World Ranking
3163
National Ranking
1596

Overview

John Y. L. Chiang is affiliated with Northeast Ohio Medical University in the United States. Their research primarily focuses on medicine, with significant contributions to oncology, epidemiology, artificial intelligence, surgery, and molecular biology. The main topics covered in their work include drug transport and resistance mechanisms, liver disease diagnosis and treatment, pediatric hepatobiliary diseases and treatments, stochastic gradient optimization techniques, privacy-preserving technologies in data, cholesterol and lipid metabolism, and gut microbiota and health.

The scientist has published extensively, with notable papers including:

  • Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy (2020), published in American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Bile acid metabolism and signaling, the microbiota, and metabolic disease (2022), Pharmacology & Therapeutics
  • Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis (2020), Liver Research
  • Discovery of farnesoid X receptor and its role in bile acid metabolism (2022), Molecular and Cellular Endocrinology
  • Interactive Relationships between Intestinal Flora and Bile Acids (2022), International Journal of Molecular Sciences

Frequent co-authors collaborating with John Y. L. Chiang include Jessica M. Ferrell, Shannon Boehme, Tiangang Li, Matthew Dilts, and Zachary Stahl.

The scientist's research has been published in various venues, with multiple publications appearing in arXiv (Cornell University), Liver Research, Cardiology Plus, Hepatology Communications, and Cellular and Molecular Gastroenterology and Hepatology.

Best Publications

  • Bile acids: regulation of synthesis.

    John Y.L. Chiang

  • Bile Acid Metabolism and Signaling

    John Y. L. Chiang

  • Bile Acid Signaling in Metabolic Disease and Drug Therapy

    Tiangang Li;John Y. L. Chiang

  • Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.

    John Y.L Chiang

  • Bile Acid Regulation of Gene Expression: Roles of Nuclear Hormone Receptors

    John Y. L. Chiang

  • Regulation of bile acid and cholesterol metabolism by PPARs.

    Tiangang Li;John Y. L. Chiang

  • Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα)

    John Y.L. Chiang;Rhonda Kimmel;Diane Stroup

  • Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

    Preeti Pathak;Cen Xie;Robert G. Nichols;Jessica M. Ferrell

  • Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

    Kwang-Hoon Song;Tiangang Li;Erika Owsley;Stephen Strom

  • Bile Acid Metabolism in Liver Pathobiology.

    John Y. L. Chiang;Jessica M. Ferrell

  • REGULATION OF BILE ACID SYNTHESIS

    John Y. L Chiang

  • Mechanism of tissue‐specific farnesoid X receptor in suppressing the expression of genes in bile‐acid synthesis in mice

    Bo Kong;Li Wang;John Y.L. Chiang;Youcai Zhang

  • Farnesoid X Receptor Responds to Bile Acids and Represses Cholesterol 7α-Hydroxylase Gene (CYP7A1) Transcription

    John Y.L. Chiang;Rhonda Kimmel;Cary Weinberger;Diane Stroup

  • Bile Acids as Metabolic Regulators and Nutrient Sensors.

    John Y. L. Chiang;Jessica M. Ferrell

  • Transcriptional Regulation of the Human Sterol 12α-Hydroxylase Gene (CYP8B1): ROLES OF HEPATOCYTE NUCLEAR FACTOR 4α IN MEDIATING BILE ACID REPRESSION *

    Ming Zhang;John Y.L. Chiang

  • Bile acids as metabolic regulators

    Tiangang Li;John Y.L. Chiang

  • Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.

    Yan Chun Li;Dan Ping Wang;J. Y. L. Chiang

  • Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy.

    John Y. L. Chiang;Jessica M. Ferrell

  • Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7α-hydroxylase gene transcription

    Tiangang Li;John Y. L. Chiang

  • Overexpression of Cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

    Tiangang Li;Michelle Matozel;Shannon Boehme;Bo Kong

Frequent Co-Authors

Douglas M. Heuman
Douglas M. Heuman Virginia Commonwealth University
William M. Pandak
William M. Pandak Virginia Commonwealth University
Phillip B. Hylemon
Phillip B. Hylemon Virginia Commonwealth University
Stephen C. Strom
Stephen C. Strom Karolinska Institute
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Kristopher W. Krausz
Kristopher W. Krausz National Institutes of Health
Gerald Salen
Gerald Salen Rutgers, The State University of New Jersey
Seung Bum Park
Seung Bum Park Seoul National University
Lucy Waskell
Lucy Waskell University of Michigan–Ann Arbor
Hans M.G. Princen
Hans M.G. Princen Netherlands Organisation for Applied Scientific Research

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