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Medicine
Sweden
2023

D-Index & Metrics

Medicine

D-Index
111
Citations
42260
World Ranking
5360
National Ranking
111

Research.com Recognitions

  • 2023 - Research.com Medicine in Sweden Leader Award

Overview

Ingemar Björkhem is affiliated with the Karolinska University Hospital in Sweden and has contributed extensively to research in Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields, including Surgery, Molecular Biology, Endocrinology, Diabetes and Metabolism, Genetics, and Pulmonary and Respiratory Medicine.

The main topics of Björkhem's research focus on Cholesterol and Lipid Metabolism, Hormonal Regulation and Hypertension, Peroxisome Proliferator-Activated Receptors, Receptor Mechanisms and Signaling, Drug Transport and Resistance Mechanisms, Estrogen and related hormone effects, and Aquaculture Nutrition and Growth.

Frequent co-authors in Björkhem's publications include Ángel Cedazo-Mı́nguez, Anna Matton, Silvia Maioli, Miia Kivipelto, and María Latorre-Leal.

Björkhem has published in several scientific venues, with multiple papers appearing in The Journal of Steroid Biochemistry and Molecular Biology and bioRxiv (Cold Spring Harbor Laboratory). Other publication venues include Science Advances, BMC Veterinary Research, and Alzheimer's Research & Therapy.

Recent papers authored or co-authored by Björkhem include:

  • Choline supplementation prevents diet induced gut mucosa lipid accumulation in post-smolt Atlantic salmon (Salmo salar L.), 2020, BMC Veterinary Research
  • 27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial, 2021, Alzheimer's Research & Therapy
  • Dose-response relationship between dietary choline and lipid accumulation in pyloric enterocytes of Atlantic salmon (Salmo salar L.) in seawater, 2020, British Journal Of Nutrition
  • Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration, 2021, Molecular Neurobiology
  • CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice, 2024, Science Advances

Best Publications

  • Brain Cholesterol: Long Secret Life Behind a Barrier

    Ingemar Björkhem;Steve Meaney

  • Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

    Dieter Lutjohann;Olof Breuer;Gunvor Ahlborg;Inger Nennesmo

  • Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

    Ingemar Björkhem;Dieter Lütjohann;Ulf Diczfalusy;Lars Ståhle

  • The antioxidant butylated hydroxytoluene protects against atherosclerosis.

    I. Bjorkhem;A. Henriksson-Freyschuss;O. Breuer;U. Diczfalusy

  • Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

    I. Björkhem

  • Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients.

    Dieter Lütjohann;Dieter Lütjohann;Andreas Papassotiropoulos;Ingemar Björkhem;Sandra Locatelli

  • Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice

    S. Alberti;G. Schuster;P. Parini;D. Feltkamp

  • Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages.

    Ingemar Bjorkhem;Olof Andersson;Ulf Diczfalusy;Bo Sevastik

  • Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.

    Kangmo Lu;Mi Hye Lee;Starr Hazard;Angela Brooks-Wilson

  • Oxysterols Friends, Foes, or Just Fellow Passengers?

    Ingemar Björkhem;Ulf Diczfalusy

  • Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

    Ingemar Björkhem;Dieter Lütjohann;Olof Breuer;Augustinas Sakinis

  • Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

    Maura Heverin;Nenad Bogdanovic;Dieter Lütjohann;Thomas Bayer

  • Disruption of Cholesterol 7α-Hydroxylase Gene in Mice II. BILE ACID DEFICIENCY IS OVERCOME BY INDUCTION OF OXYSTEROL 7α-HYDROXYLASE

    Margrit Schwarz;Erik G. Lund;Kenneth D. R. Setchell;Herbert J. Kayden

  • Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment.

    D Lütjohann;I Björkhem;U.F. Beil;K von Bergmann

  • Effects of Cholesteryl Ester Transfer Protein Inhibition on High-Density Lipoprotein Subspecies, Apolipoprotein A-I Metabolism, and Fecal Sterol Excretion

    Margaret E. Brousseau;Margaret R. Diffenderfer;John S. Millar;Chorthip Nartsupha

  • Lipoprotein Oxidation and Progression of Carotid Atherosclerosis

    Jukka T. Salonen;Kristiina Nyyssonen;Riitta Salonen;Elina Porkkala-sarataho

  • Do oxysterols control cholesterol homeostasis

    Ingemar Björkhem

  • Elimination of Cholesterol in Macrophages and Endothelial Cells by the Sterol 27-Hydroxylase Mechanism COMPARISON WITH HIGH DENSITY LIPOPROTEIN-MEDIATED REVERSE CHOLESTEROL TRANSPORT

    Amir Babiker;Olof Andersson;Erik Lund;Rui-Juan Xiu

  • Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol

    I Bjorkhem;KM Boberg;E. Leitersdorf

  • Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming

    Sebastian Zimmer;Alena Grebe;Siril Skaret Bakke;Siril Skaret Bakke;Niklas Bode

Frequent Co-Authors

Ulf Diczfalusy
Ulf Diczfalusy Karolinska University Hospital
Dieter Lütjohann
Dieter Lütjohann University Hospital Bonn
Bo Angelin
Bo Angelin Karolinska University Hospital
Jan-Åke Gustafsson
Jan-Åke Gustafsson University of Houston
Angel Cedazo-Minguez
Angel Cedazo-Minguez Karolinska Institute
Lars Berglund
Lars Berglund Royal Institute of Technology
William J. Griffiths
William J. Griffiths Swansea University
Miia Kivipelto
Miia Kivipelto University of Eastern Finland
Bengt Winblad
Bengt Winblad Karolinska Institute
Ludger Schöls
Ludger Schöls University of Tübingen

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