World's Best Scientists 2026 revealed!
Jan-Åke Gustafsson

Jan-Åke Gustafsson

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Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
200
Citations
180216
World Ranking
294
National Ranking
193

Biology and Biochemistry

D-Index
203
Citations
182936
World Ranking
30
National Ranking
25

Medicine

D-Index
203
Citations
182899
World Ranking
160
National Ranking
107

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2026 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2002 - Member of the National Academy of Sciences
  • 2000 - Fellow of the American Academy of Arts and Sciences

Overview

Jan-Åke Gustafsson is affiliated with the University of Houston in the United States and has research publications predominantly in the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their work encompasses 67 publications in biochemistry-related disciplines and 64 in medicine, with key subfields including Genetics, Immunology, Molecular Biology, Surgery, and Oncology.

The scientist's research topics focus on areas such as estrogen and related hormone effects, cholesterol and lipid metabolism, and the effects and risks of endocrine disrupting chemicals. Additional topics include immune cell function and interaction, drug transport and resistance mechanisms, cancer, lipids, and metabolism, and prostate cancer treatment and research.

Frequent publication venues for their work are:

  • Proceedings of the National Academy of Sciences
  • International Journal of Molecular Sciences
  • The Journal of Experimental Medicine
  • Molecular Psychiatry
  • Vitamins and hormones

Frequent co-authors include:

  • Margaret Warner
  • Wanfu Wu
  • Per Antonson
  • Xiaotang Fan
  • Ivan Nalvarte

Selected recent papers by Jan-Åke Gustafsson include:

  • Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain (2020), published in The Journal of Experimental Medicine
  • Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis (2022), published in Arteriosclerosis Thrombosis and Vascular Biology
  • Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes (2020), published in Cancer Letters
  • G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERα and ERβ in pancreatic beta cells (2022), published in Environment International
  • Estrogen receptor β deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior (2022), published in Microbiome

Jan-Åke Gustafsson has been recognized with memberships and fellowships, including:

  • Member of the National Academy of Sciences (2002)
  • Fellow of the American Academy of Arts and Sciences (2000)

Best Publications

  • Cloning of a novel receptor expressed in rat prostate and ovary.

    George G.J.M. Kuiper;Eva Enmark;Markku Pelto-Huikko;Stefan Nilsson

  • COMPARISON OF THE LIGAND BINDING SPECIFICITY AND TRANSCRIPT TISSUE DISTRIBUTION OF ESTROGEN RECEPTORS ALPHA AND BETA

    George G.J.M. Kuiper;Bo Carlsson;Kaj Grandien;Eva Enmark

  • Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

    George G.J.M. Kuiper;Josephine G. Lemmen;Bo Carlsson;J. Christopher Corton

  • Molecular basis of agonism and antagonism in the oestrogen receptor.

    Andrzej M. Brzozowski;Ashley C. W. Pike;Zbigniew Dauter;Roderick E. Hubbard

  • DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER$g(a) AND ER$g(b) AT AP1 SITES

    Peter J. Kushner;Jan-Ake Gustafsson;George G. J. M. Kuiper;Stefan Nilsson

  • Mechanisms of Estrogen Action

    Stefan Nilsson;Sari Mäkelä;Eckardt Treuter;Michel Tujague

  • Estrogen Receptors: How Do They Signal and What Are Their Targets

    Nina Heldring;Ashley Pike;Sandra Andersson;Jason Matthews

  • Generation and reproductive phenotypes of mice lacking estrogen receptor β

    John H. Krege;Jeffrey B. Hodgin;John F. Couse;Eva Enmark

  • Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern.

    Eva Enmark;Markku Pelto-Huikko;Markku Pelto-Huikko;Kaj Grandien;Svetlana Lagercrantz

  • Principles for modulation of the nuclear receptor superfamily

    Hinrich Gronemeyer;Jan Åke Gustafsson;Vincent Laudet

  • Structure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist

    Ashley C.W. Pike;Andrzej M. Brzozowski;Roderick E. Hubbard;Tomas Bonn

  • Tissue Distribution and Quantitative Analysis of Estrogen Receptor-α (ERα) and Estrogen Receptor-β (ERβ) Messenger Ribonucleic Acid in the Wild-Type and ERα-Knockout Mouse

    John F. Couse;Jonathan Lindzey;Kaj Grandien;Jan-Åke Gustafsson

  • A unified nomenclature system for the nuclear receptor superfamily

    J. Auwerx;E. Baulieu;M. Beato;M. Becker-Andre

  • Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor.

    Martin Göttlicher;Eva Widmark;Qiao Li;Jan Åke Gustafsson

  • Estrogen signaling: a subtle balance between ER alpha and ER beta.

    Jason Matthews;Jan-Ake Gustafsson

  • Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists.

    Tomas Barkhem;Bo Carlsson;Yvonne Nilsson;Eva Enmark

  • Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha.

    Katarina Pettersson;Kaj Grandien;George G. J. M. Kuiper;Jan-Åke Gustafsson

  • Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA

    Roger Miesfeld;Sandro Rusconi;Paul J. Godowski;Bonnie A. Maler

  • International Union of Pharmacology. LXIV. Estrogen Receptors

    Karin Dahlman-Wright;Vincent Cavailles;Suzanne A. Fuqua;V. Craig Jordan

  • Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region.

    Farhang Payvar;Donald DeFranco;Gary L. Firestone;Bruce Edgar

Frequent Co-Authors

Margaret Warner
Margaret Warner University of Houston
Karin Dahlman-Wright
Karin Dahlman-Wright Karolinska Institute
Jan Carlstedt-Duke
Jan Carlstedt-Duke Nanyang Technological University
Kjell Fuxe
Kjell Fuxe Karolinska Institute
Sam Okret
Sam Okret Karolinska Institute
Claes Ohlsson
Claes Ohlsson University of Gothenburg
Anthony P. H. Wright
Anthony P. H. Wright Karolinska Institute
Eckardt Treuter
Eckardt Treuter Karolinska Institute
Lorenz Poellinger
Lorenz Poellinger Karolinska Institute
Jan Sjövall
Jan Sjövall Karolinska Institute

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