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Donald P. McDonnell

Donald P. McDonnell

D-Index & Metrics

Biology and Biochemistry

D-Index
116
Citations
44715
World Ranking
756
National Ranking
477

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors
  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Donald P. McDonnell is affiliated with Duke University in the United States. Their research focuses broadly on biochemistry, genetics, and molecular biology, alongside significant contributions to medicine. Within these domains, their work frequently addresses molecular biology, immunology, genetics, oncology, and pulmonary and respiratory medicine.

Key topics in their research include estrogen and related hormone effects, immune cell function and interaction, prostate cancer treatment and research, cancer-related molecular pathways, immune cells in cancer, advanced breast cancer therapies, and cancer, hypoxia, and metabolism.

McDonnell has published extensively in prominent venues where they have multiple contributions. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Cancer Immunology Research, Clinical Cancer Research, Cancer Research, and UNC Libraries.

Frequent collaborators in McDonnell's research include Ching-yi Chang, Suzanne E. Wardell, Sandeep Artham, John D. Norris, and Binita Chakraborty.

Selected recent publications are as follows:

  • "Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer," 2021, Nature Communications
  • "Estrogen Receptor Signaling in the Immune System," 2022, Endocrine Reviews
  • "The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor," 2020, Molecular Cancer Therapeutics
  • "Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice," 2023, Nature Communications
  • "Next-Generation Endocrine Therapies for Breast Cancer," 2021, Journal of Clinical Oncology

McDonnell has been recognized with several awards, including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2011 and a Fellow of the National Academy of Inventors in 2020.

Best Publications

  • The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens.

    Julie M. Hall;Donald P. McDonnell

  • Cloning and expression of full-length cDNA encoding human vitamin D receptor.

    A. R. Baker;D. P. McDonnell;M. Hughes;T. M. Crisp

  • Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

    E Vegeto;M M Shahbaz;D X Wen;M E Goldman

  • Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.

    M T Tzukerman;A Esty;D Santiso-Mere;P Danielian

  • Evaluation of Chemicals with Endocrine Modulating Activity in a Yeast-Based Steroid Hormone Receptor Gene Transcription Assay

    Kevin W. Gaido;Linda S. Leonard;Stephanie Lovell;Janet C. Gould

  • 27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

    Erik R. Nelson;Suzanne E. Wardell;Jeff S. Jasper;Sunghee Park

  • Connections and Regulation of the Human Estrogen Receptor

    Donald P. McDonnell;John D. Norris

  • Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.

    D P McDonnell;D L Clemm;T Hermann;M E Goldman

  • Molecular cloning of complementary DNA encoding the avian receptor for vitamin D.

    Donald P. Mcdonnell;David J. Mangelsdorf;J. Wesley Pike;Mark R. Haussler

  • Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol

    Janet C. Gould;Linda S. Leonard;Susan C. Maness;Brandee L. Wagner

  • Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells

    John P. Chute;Garrett G. Muramoto;John Whitesides;Michael Colvin

  • The Human Estrogen Receptor-α Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators

    Ashini L. Wijayaratne;Donald P. McDonnell

  • Variant Human Breast Tumor Estrogen Receptor with Constitutive Transcriptional Activity

    Suzanne A. W. Fuqua;Saundra D. Fitzgerald;Gary C. Chamness;Atul K. Tandon

  • Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta

    Lisa A. Paige;Dale J. Christensen;Hanne Grøn;John D. Norris

  • International Union of Pharmacology. LXV. The Pharmacology and Classification of the Nuclear Receptor Superfamily: Glucocorticoid, Mineralocorticoid, Progesterone, and Androgen Receptors

    Nick Z. Lu;Suzanne E. Wardell;Kerry L. Burnstein;Donald Defranco

  • Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay.

    Karen Oerter Klein;Jeffrey Baron;Michael J. Colli;Donald P. McDonnell

  • The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells.

    D. X. Wen;You-Feng Xu;D. E. Mais;M. E. Goldman

  • Peptide Antagonists of the Human Estrogen Receptor

    John D. Norris;Lisa A. Paige;Dale J. Christensen;Ching-Yi Chang

  • The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor.

    Elisabetta Vegeto;George F. Allan;William T. Schrader;Ming-Jer Tsai

  • Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β

    Ching Yi Chang;John D. Norris;Hanne Grøn;Lisa A. Paige

Frequent Co-Authors

Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Jeffrey C. Rathmell
Jeffrey C. Rathmell Vanderbilt University Medical Center
J. Wesley Pike
J. Wesley Pike University of Wisconsin–Madison
William T. Schrader
William T. Schrader Baylor College of Medicine
Stephen Safe
Stephen Safe Texas A&M University
Nelson J. Chao
Nelson J. Chao Duke University
Zafar Nawaz
Zafar Nawaz University of Miami
Myles Brown
Myles Brown Harvard University
Ming-Jer Tsai
Ming-Jer Tsai Baylor College of Medicine
Nancy L. Weigel
Nancy L. Weigel Baylor College of Medicine

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