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Biology and Biochemistry

D-Index
84
Citations
20425
World Ranking
3390
National Ranking
1704

Overview

Dean P. Edwards is affiliated with Baylor College of Medicine in the United States. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and genetics as primary subfields of study. Their scholarly output includes significant contributions to oncology, cellular and molecular neuroscience, and cell biology.

The main topics of Edwards's work include:

  • Estrogen and related hormone effects
  • Advanced biosensing techniques and applications
  • Advanced biosensing and bioanalysis techniques
  • Monoclonal and polyclonal antibodies research
  • Nuclear receptors and signaling
  • Retinoids in leukemia and cellular processes
  • Gene expression and cancer classification

Edwards has published extensively, with key recent papers as follows:

  • Systemic distribution of progesterone receptor subtypes in human tissues, 2020, The Journal of Steroid Biochemistry and Molecular Biology
  • Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration, 2021, Journal of Biomolecular Techniques JBT
  • International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023, 2023, Pharmacological Reviews
  • Molecular mechanisms of TWIST1-regulated transcription in EMT and cancer metastasis, 2023, EMBO Reports
  • High-throughput profiling of histone post-translational modifications and chromatin modifying proteins by reverse phase protein array, 2022, Journal of Proteomics

Frequent co-authors working alongside Edwards include:

  • Shixia Huang
  • Sandra L. Grimm
  • Cristian Coarfa
  • Kimal Rajapakshe
  • Derek W. Cain

Their work has appeared in several publication venues with multiple contributions, including:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • Journal of Biomolecular Techniques JBT
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Pharmacological Reviews
  • EMBO Reports

Best Publications

  • Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases.

    Viroj Boonyaratanakornkit;Margaret Porter Scott;Vered Ribon;Vered Ribon;Lori Sherman

  • REGULATION OF SIGNAL TRANSDUCTION PATHWAYS BY ESTROGEN AND PROGESTERONE

    Dean P Edwards

  • Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis

    George R. Attia;Khaled Zeitoun;Dean Edwards;Alan Johns

  • The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors

    Sergio A. Onate;Viroj Boonyaratanakornkit;Thomas E. Spencer;Sophia Y. Tsai

  • Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

    G. F. Allan;X. Leng;S. Y. Tsai;N. L. Weigel

  • High-Mobility Group Chromatin Proteins 1 and 2 Functionally Interact with Steroid Hormone Receptors To Enhance Their DNA Binding In Vitro and Transcriptional Activity in Mammalian Cells

    Viroj Boonyaratanakornkit;Vida Melvin;Paul Prendergast;Magda Altmann

  • The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding.

    Paloma H. Giangrande;Erin A. Kimbrel;Dean P. Edwards;Donald P. McDonnell

  • The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

    Candace A. Beck;Nancy L. Weigel;Marissa L. Moyer;Steven K. Nordeen

  • Progesterone receptor transcription and non-transcription signaling mechanisms.

    Susan A. Leonhardt;Viroj Boonyaratanakornkit;Dean P. Edwards

  • The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle.

    Viroj Boonyaratanakornkit;Eileen McGowan;Lori Sherman;Michael A. Mancini

  • The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences.

    S A Oñate;P Prendergast;J P Wagner;M Nissen

  • Immunologic analysis of human breast cancer progesterone receptors. 1. Immunoaffinity purification of transformed receptors and production of monoclonal antibodies.

    Patricia A. Estes;Eric J. Suba;Janet Lawler-Heavner;Dorraya El-Ashry-Stowers

  • Transcriptional signature primes human oral mucosa for rapid wound healing.

    Ramiro Iglesias-Bartolome;Akihiko Uchiyama;Alfredo A. Molinolo;Alfredo A. Molinolo;Loreto Abusleme

  • Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

    Toshio M. Igarashi;Kaylon L. Bruner-Tran;Grant R. Yeaman;Bruce A. Lessey

  • The biology of progesterone receptor in the normal mammary gland and in breast cancer.

    Alison E. Obr;Dean P. Edwards

  • Human sperm plasma membrane progesterone receptor(s) and the acrosome reaction.

    Khalida Sabeur;Dean P. Edwards;Stanley Meizel

  • Receptor mechanisms mediating non-genomic actions of sex steroids.

    Viroj Boonyaratanakornkit;Dean P. Edwards

  • The role of coactivators and corepressors in the biology and mechanism of action of steroid hormone receptors.

    Dean P. Edwards

  • Distribution of an Estrogen-induced Protein with a Molecular Weight of 24,000 in Normal and Malignant Human Tissues and Cells

    Daniel R. Ciocca;David J. Adams;Dean P. Edwards;Robert J. Bjercke

  • Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo.

    Marc J. Tetel;Paloma H. Giangrande;Susan A. Leonhardt;Donald P. McDonnell

Frequent Co-Authors

Nancy L. Weigel
Nancy L. Weigel Baylor College of Medicine
William L. McGuire
William L. McGuire The University of Texas Health Science Center at San Antonio
Cristian Coarfa
Cristian Coarfa Baylor College of Medicine
Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Susan G. Hilsenbeck
Susan G. Hilsenbeck Baylor College of Medicine
Jeffrey M. Rosen
Jeffrey M. Rosen Baylor College of Medicine
Rachel Schiff
Rachel Schiff Baylor College of Medicine
Mair E. A. Churchill
Mair E. A. Churchill University of Colorado Denver
John P. Lydon
John P. Lydon Baylor College of Medicine
David J. Adams
David J. Adams Wellcome Sanger Institute

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