World's Best Scientists 2026 revealed!
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Best Female Scientists
2025

D-Index & Metrics

Best Female Scientists

D-Index
114
Citations
41364
World Ranking
746
National Ranking
454

Biology and Biochemistry

D-Index
116
Citations
42584
World Ranking
767
National Ranking
482

Sophia Y. Tsai publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Sophia Y. Tsai sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 305 publications — 79th percentile

79% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Sophia Y. Tsai D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Sophia Y. Tsai sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 116 D-Index — 96th percentile

96% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award

Overview

Sophia Y. Tsai is affiliated with Baylor College of Medicine in the United States and specializes in Biochemistry, Genetics, and Molecular Biology. Their research primarily focuses on Molecular Biology, Cellular and Molecular Neuroscience, and Genetics, with additional interests in Endocrinology, Diabetes and Metabolism, and Information Systems.

The scientist's work addresses various topics related to Nuclear Receptors and Signaling, Protein Degradation and Inhibitors, Ubiquitin and Proteasome Pathways, Genomics and Chromatin Dynamics, Estrogen and Related Hormone Effects, Hormonal Regulation and Hypertension, as well as Neuroscience and Neuropharmacology Research.

Below is a list of recent publications by Sophia Y. Tsai:

  • Opposing Functions of BRD4 Isoforms in Breast Cancer, 2020, Molecular Cell
  • Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment, 2020, Science Advances
  • Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction, 2020, PLoS Genetics
  • PCR172 Communicating Challenging Concepts in Preference Research: Developing and Testing a Discrete Choice Experiment (DCE) Survey in Metastatic Castration-Resistant Prostate Cancer (MCRPC), 2023, Value in Health
  • 2F. COUP-TF-like receptors in GtoPdb v.2023.1, 2023, IUPHAR/BPS Guide to Pharmacology CITE

Frequent co-authors collaborating with Sophia Y. Tsai include:

  • Ming-Jer Tsai
  • Leiming Wang
  • Mafei Xu
  • Shwu-Yuan Wu
  • Chien-Fei Lee

The scientist has published repeatedly in the following venues:

  • Molecular Cell
  • Science Advances
  • PLoS Genetics
  • Value in Health
  • IUPHAR/BPS Guide to Pharmacology CITE

Sophia Y. Tsai's contributions span multiple disciplines at the intersection of molecular biology and neuroscience. Their research includes exploration of nuclear receptor function and signaling pathways, mechanisms of protein degradation, and the molecular dynamics underlying chromatin regulation. Additionally, Tsai's work covers hormone-related biological effects and the progression of diseases such as cancer and Parkinson's disease through cellular and molecular mechanisms.

Best Publications

  • Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

    Sergio A. Oñate;Sophia Y. Tsai;Ming-Jer Tsai;Bert W. O'Malley

  • Steroid receptor coactivator-1 is a histone acetyltransferase

    T E Spencer;G Jenster;G Jenster;M M Burcin;C D Allis

  • A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex.

    Rainer B Lanz;Neil J McKenna;Sergio A Onate;Urs Albrecht

  • Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity

    Li Ru You;Fu Jung Lin;Christopher T. Lee;Francesco J. DeMayo

  • Partial Hormone Resistance in Mice with Disruption of the Steroid Receptor Coactivator-1 (SRC-1) Gene

    Jianming Xu;Yuhong Qiu;Francesco J. DeMayo;Sophia Y. Tsai

  • Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.

    H Shibata;T E Spencer;S A Oñate;G Jenster

  • A regulatory system for use in gene transfer

    Yaolin Wang;Bert W. O'Malley;Sophia Y. Tsai

  • Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

    Sophia Y. Tsai;Jan Carlstedt-Duke;Nancy L. Weigel;Karin Dahlman

  • COUP transcription factor is a member of the steroid receptor superfamily.

    Lee-Ho Wang;Sophia Y. Tsai;Richard G. Cook;Wanda G. Beattie

  • The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily

    Zafar Nawaz;David M. Lonard;Carolyn L. Smith;Efrat Lev-Lehman

  • Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.

    Neil J. McKenna;Jianming Xu;Zafar Nawaz;Sophia Y. Tsai

  • Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature

    R. Sathish Srinivasan;Miriam E. Dillard;Oleg V. Lagutin;Fu Jung Lin

  • The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors

    Sergio A. Onate;Viroj Boonyaratanakornkit;Thomas E. Spencer;Sophia Y. Tsai

  • The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

    Fred A. Pereira;Yuhong Qiu;Ge Zhou;Ming-Jer Tsai

  • Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.

    Austin J. Cooney;Sophia Y. Tsai;Bert W. O'Malley;Ming Jer Tsai

  • Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

    G. F. Allan;X. Leng;S. Y. Tsai;N. L. Weigel

  • Chick Ovalbumin Upstream Promoter-Transcription Factors (COUP-TFs): Coming of Age

    Sophia Y. Tsai;Ming-Jer Tsai

  • Selective Phosphorylations of the SRC-3/AIB1 Coactivator Integrate Genomic Reponses to Multiple Cellular Signaling Pathways

    Ray-Chang Wu;Jun Qin;Ping Yi;Jiemin Wong

  • Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.

    Aria Baniahmad;Ilho Ha;Danny Reinberg;Sophia Tsai

  • Adenovirus-mediated regulable target gene expression in vivo

    Mark M. Burcin;Gudrun Schiedner;Stefan Kochanek;Sophia Y. Tsai

Frequent Co-Authors

Ming-Jer Tsai
Ming-Jer Tsai Baylor College of Medicine
Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Francesco J. DeMayo
Francesco J. DeMayo National Institutes of Health
John P. Lydon
John P. Lydon Baylor College of Medicine
Jun Qin
Jun Qin Baylor College of Medicine
Austin J. Cooney
Austin J. Cooney Baylor College of Medicine
Milan K. Bagchi
Milan K. Bagchi University of Illinois at Urbana-Champaign
Dennis R. Roop
Dennis R. Roop University of Colorado Anschutz Medical Campus
Jiemin Wong
Jiemin Wong East China Normal University
Chad J. Creighton
Chad J. Creighton Baylor College of Medicine

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