World's Best Scientists 2026 revealed!
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Best Female Scientists
2025

D-Index & Metrics

Best Female Scientists

D-Index
114
Citations
41364
World Ranking
746
National Ranking
454

Biology and Biochemistry

D-Index
116
Citations
42584
World Ranking
767
National Ranking
482

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award

Overview

Sophia Y. Tsai is affiliated with Baylor College of Medicine in the United States and specializes in Biochemistry, Genetics, and Molecular Biology. Their research primarily focuses on Molecular Biology, Cellular and Molecular Neuroscience, and Genetics, with additional interests in Endocrinology, Diabetes and Metabolism, and Information Systems.

The scientist's work addresses various topics related to Nuclear Receptors and Signaling, Protein Degradation and Inhibitors, Ubiquitin and Proteasome Pathways, Genomics and Chromatin Dynamics, Estrogen and Related Hormone Effects, Hormonal Regulation and Hypertension, as well as Neuroscience and Neuropharmacology Research.

Below is a list of recent publications by Sophia Y. Tsai:

  • Opposing Functions of BRD4 Isoforms in Breast Cancer, 2020, Molecular Cell
  • Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment, 2020, Science Advances
  • Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction, 2020, PLoS Genetics
  • PCR172 Communicating Challenging Concepts in Preference Research: Developing and Testing a Discrete Choice Experiment (DCE) Survey in Metastatic Castration-Resistant Prostate Cancer (MCRPC), 2023, Value in Health
  • 2F. COUP-TF-like receptors in GtoPdb v.2023.1, 2023, IUPHAR/BPS Guide to Pharmacology CITE

Frequent co-authors collaborating with Sophia Y. Tsai include:

  • Ming-Jer Tsai
  • Leiming Wang
  • Mafei Xu
  • Shwu-Yuan Wu
  • Chien-Fei Lee

The scientist has published repeatedly in the following venues:

  • Molecular Cell
  • Science Advances
  • PLoS Genetics
  • Value in Health
  • IUPHAR/BPS Guide to Pharmacology CITE

Sophia Y. Tsai's contributions span multiple disciplines at the intersection of molecular biology and neuroscience. Their research includes exploration of nuclear receptor function and signaling pathways, mechanisms of protein degradation, and the molecular dynamics underlying chromatin regulation. Additionally, Tsai's work covers hormone-related biological effects and the progression of diseases such as cancer and Parkinson's disease through cellular and molecular mechanisms.

Best Publications

  • Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

    Sergio A. Oñate;Sophia Y. Tsai;Ming-Jer Tsai;Bert W. O'Malley

  • Steroid receptor coactivator-1 is a histone acetyltransferase

    T E Spencer;G Jenster;G Jenster;M M Burcin;C D Allis

  • A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex.

    Rainer B Lanz;Neil J McKenna;Sergio A Onate;Urs Albrecht

  • Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity

    Li Ru You;Fu Jung Lin;Christopher T. Lee;Francesco J. DeMayo

  • Partial Hormone Resistance in Mice with Disruption of the Steroid Receptor Coactivator-1 (SRC-1) Gene

    Jianming Xu;Yuhong Qiu;Francesco J. DeMayo;Sophia Y. Tsai

  • Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.

    H Shibata;T E Spencer;S A Oñate;G Jenster

  • A regulatory system for use in gene transfer

    Yaolin Wang;Bert W. O'Malley;Sophia Y. Tsai

  • Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

    Sophia Y. Tsai;Jan Carlstedt-Duke;Nancy L. Weigel;Karin Dahlman

  • COUP transcription factor is a member of the steroid receptor superfamily.

    Lee-Ho Wang;Sophia Y. Tsai;Richard G. Cook;Wanda G. Beattie

  • The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily

    Zafar Nawaz;David M. Lonard;Carolyn L. Smith;Efrat Lev-Lehman

  • Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.

    Neil J. McKenna;Jianming Xu;Zafar Nawaz;Sophia Y. Tsai

  • Lineage tracing demonstrates the venous origin of the mammalian lymphatic vasculature

    R. Sathish Srinivasan;Miriam E. Dillard;Oleg V. Lagutin;Fu Jung Lin

  • The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors

    Sergio A. Onate;Viroj Boonyaratanakornkit;Thomas E. Spencer;Sophia Y. Tsai

  • The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development

    Fred A. Pereira;Yuhong Qiu;Ge Zhou;Ming-Jer Tsai

  • Chicken ovalbumin upstream promoter transcription factor (COUP-TF) dimers bind to different GGTCA response elements, allowing COUP-TF to repress hormonal induction of the vitamin D3, thyroid hormone, and retinoic acid receptors.

    Austin J. Cooney;Sophia Y. Tsai;Bert W. O'Malley;Ming Jer Tsai

  • Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

    G. F. Allan;X. Leng;S. Y. Tsai;N. L. Weigel

  • Chick Ovalbumin Upstream Promoter-Transcription Factors (COUP-TFs): Coming of Age

    Sophia Y. Tsai;Ming-Jer Tsai

  • Selective Phosphorylations of the SRC-3/AIB1 Coactivator Integrate Genomic Reponses to Multiple Cellular Signaling Pathways

    Ray-Chang Wu;Jun Qin;Ping Yi;Jiemin Wong

  • Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone.

    Aria Baniahmad;Ilho Ha;Danny Reinberg;Sophia Tsai

  • Adenovirus-mediated regulable target gene expression in vivo

    Mark M. Burcin;Gudrun Schiedner;Stefan Kochanek;Sophia Y. Tsai

Frequent Co-Authors

Ming-Jer Tsai
Ming-Jer Tsai Baylor College of Medicine
Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Francesco J. DeMayo
Francesco J. DeMayo National Institutes of Health
John P. Lydon
John P. Lydon Baylor College of Medicine
Jun Qin
Jun Qin Baylor College of Medicine
Austin J. Cooney
Austin J. Cooney Baylor College of Medicine
Milan K. Bagchi
Milan K. Bagchi University of Illinois at Urbana-Champaign
Dennis R. Roop
Dennis R. Roop University of Colorado Anschutz Medical Campus
Jiemin Wong
Jiemin Wong East China Normal University
Chad J. Creighton
Chad J. Creighton Baylor College of Medicine

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