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D-Index & Metrics

Biology and Biochemistry

D-Index
96
Citations
35002
World Ranking
1814
National Ranking
1002

Overview

Dennis R. Roop is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research predominantly spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine, reflecting a multidisciplinary approach to molecular and cellular studies.

Their contributions include 39 publications in Biochemistry, Genetics and Molecular Biology and 20 in Medicine, with significant focus on subfields such as Cell Biology, Molecular Biology, Immunology, Dermatology, and Genetics. This diverse expertise supports a wide scope of biological and medical inquiries.

The main areas of research explored by Roop cover topics including Skin and Cellular Biology Research, Dermatology and Skin Diseases, Cellular Mechanics and Interactions, melanin and skin pigmentation, Immunotherapy and Immune Responses, Genomics, phytochemicals, and oxidative stress, as well as Skin Protection and Aging.

Key recent papers authored or co-authored by Roop include:

  • "Loricrin: Past, Present, and Future," 2020, International Journal of Molecular Sciences
  • "The KEAP1/NRF2 Signaling Pathway in Keratinization," 2020, Antioxidants
  • "NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy," 2020, The Journal of Immunology
  • "Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling," 2020, Journal of Investigative Dermatology
  • "A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa," 2024, Nature Communications

Roop frequently collaborates with:

  • Ganna Bilousova
  • Yosuke Ishitsuka
  • Igor Kogut
  • Patrick S. McGrath
  • Anna L. Bruckner

Their work is most commonly published in the Journal of Investigative Dermatology, with at least 14 publications in this venue. Other venues include Antioxidants, bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, and The Journal of Immunology.

Best Publications

  • p63 is a p53 homologue required for limb and epidermal morphogenesis.

    Alea A. Mills;Binhai Zheng;Xiao-Jing Wang;Hannes Vogel

  • Molecular and Cellular Biology of Intermediate Filaments

    Peter M. Steinert;Dennis R. Roop

  • Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

    Nobunao Wakabayashi;Ken Itoh;Junko Wakabayashi;Hozumi Motohashi

  • p63 is the molecular switch for initiation of an epithelial stratification program

    Maranke I. Koster;Soeun Kim;Alea A. Mills;Francesco J. DeMayo

  • Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.

    S H Yuspa;A E Kilkenny;P M Steinert;D R Roop

  • Multiple defects and perinatal death in mice deficient in follistatin

    Martin M. Matzuk;Nalfang Lu;Hannes Vogel;Klaus Sellheyer

  • Functional analysis of activins during mammalian development

    Martin M. Matzuk;T. Rajendra Kumar;Anne Vassalli;Jackie R. Bickenbach

  • The molecular biology of intermediate filaments.

    Peter M. Steinert;Alasdair C. Steven;Dennis R. Roop

  • Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.

    Fang Li;Qian Huang;Qian Huang;Jiang Chen;Yuanlin Peng

  • Identification of a major keratinocyte cell envelope protein, loricrin.

    Thomas Mehrel;Daniel Hohl;Joseph A. Rothnagel;Mary A. Longley

  • Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies.

    John R. Stanley;Toshihiro Tanaka;Stephan Mueller;Vera Klaus-Kovtun

  • Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

    Bach Cuc Nguyen;Karine Lefort;Anna Mandinova;Dario Antonini

  • Deregulated expression of c-Myc depletes epidermal stem cells.

    Rebekah L. Waikel;Yasuhiro Kawachi;Patricia A. Waikel;Xiao-Jing Wang

  • Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments

    Peter M. Steinert;Robert H. Rice;Dennis R. Roop;Benes L. Trus

  • Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis

    J. A. Rothnagel;A. M. Dominey;L. D. Dempsey;M. A. Longley

  • Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins.

    D Hohl;T Mehrel;U Lichti;M L Turner

  • Mechanisms regulating epithelial stratification.

    Maranke I. Koster;Dennis R. Roop

  • Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

    David B. Klug;Carla Carter;Elizabeth Crouch;Dennis Roop

  • Lessons from Loricrin-Deficient Mice: Compensatory Mechanisms Maintaining Skin Barrier Function in the Absence of a Major Cornified Envelope Protein

    Peter J. Koch;Pierre A. de Viragh;Pierre A. de Viragh;Elisabeth Scharer;Elisabeth Scharer;Donnie Bundman

  • Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice

    Klaus Sellheyer;Jackie R. Bickenbach;Joseph A. Rothnagel;Donnie Bundman

Frequent Co-Authors

Joseph A. Rothnagel
Joseph A. Rothnagel University of Queensland
Stuart H. Yuspa
Stuart H. Yuspa National Institutes of Health
Peter M. Steinert
Peter M. Steinert National Institutes of Health
Daniel Hohl
Daniel Hohl University of Lausanne
David A. Norris
David A. Norris University of Colorado Anschutz Medical Campus
Alasdair C. Steven
Alasdair C. Steven National Institutes of Health
Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Sophia Y. Tsai
Sophia Y. Tsai Baylor College of Medicine
Ming-Jer Tsai
Ming-Jer Tsai Baylor College of Medicine
Savio L. C. Woo
Savio L. C. Woo Icahn School of Medicine at Mount Sinai

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