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Omar M. A. El-Agnaf

Omar M. A. El-Agnaf

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
21993
World Ranking
6205
National Ranking
4

Overview

Omar M. A. El-Agnaf is affiliated with Hamad bin Khalifa University in Qatar and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. The focus of their work often centers on neurology, molecular biology, and physiology within the broader context of cellular and molecular neuroscience and infectious diseases.

The scientist's research covers a range of topics, primarily addressing:

  • Parkinson's Disease Mechanisms and Treatments
  • Neurological disorders and treatments
  • Botulinum Toxin and Related Neurological Disorders
  • Alzheimer's disease research and treatments
  • Cellular transport and secretion
  • Nuclear Receptors and Signaling
  • Lysosomal Storage Disorders Research

Omar M. A. El-Agnaf has published several papers in leading scientific journals. Among the recent papers are:

  • Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates, 2020, Brain
  • α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity, 2022, Proceedings of the National Academy of Sciences
  • Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease, 2021, npj Parkinson's Disease
  • Diagnostic, Prognostic, and Mechanistic Biomarkers of Diabetes Mellitus-Associated Cognitive Decline, 2022, International Journal of Molecular Sciences
  • Safety and immunogenicity of the α-synuclein active immunotherapeutic PD01A in patients with Parkinson's disease: a randomised, single-blinded, phase 1 trial, 2020, The Lancet Neurology

Their frequent co-authors include Nishant N. Vaikath, Nour K. Majbour, Simona S. Ghanem, Houari Abdesselem, and Ilham Y. Abdi, with numerous collaborative publications alongside these researchers.

Key publication venues where Omar M. A. El-Agnaf has contributed include:

  • International Journal of Molecular Sciences
  • Neurobiology of Disease
  • Molecular Neurodegeneration
  • Journal of Parkinson's Disease
  • bioRxiv (Cold Spring Harbor Laboratory)

The scientific work primarily pertains to medicine and intersects with various biological subfields linked to neurodegenerative diseases and neurological conditions. The research covers molecular mechanisms, biomarkers, immunotherapeutics, and disease-associated cognitive impairments.

Best Publications

  • Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium

    Ian G. McKeith;Bradley F. Boeve;Dennis W. DIckson;Glenda Halliday

  • Detection of oligomeric forms of α-synuclein protein in human plasma as a potential biomarker for Parkinson’s disease

    Omar M. A. El-Agnaf;Sultan A. Salem;Katerina E. Paleologou;Martin D. Curran

  • Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases.

    G. Brent Irvine;Omar M. El-Agnaf;Ganesh M. Shankar;Dominic M. Walsh;Dominic M. Walsh

  • α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

    Bruno Fauvet;Martial Kamdem Mbefo;Mohamed-Bilal Fares;Carole Desobry

  • α-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

    Omar M. A. El-Agnaf;Sultan A. Salem;Katerina E. Paleologou;Leanne J. Cooper

  • Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease

    T. Tokuda;M.M. Qureshi;M.T. Ardah;S. Varghese

  • Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments

    Omar M.A El-Agnaf;Ross Jakes;Martin D Curran;Derek Middleton;Derek Middleton

  • Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.

    Takahiko Tokuda;Sultan A. Salem;David Allsop;Toshiki Mizuno

  • Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration

    Brit Mollenhauer;Valerie Cullen;Ilana Kahn;Bryan Krastins

  • Formation of hydrogen peroxide and hydroxyl radicals from Aβ and α-synuclein as a possible mechanism of cell death in Alzheimer’s disease and Parkinson’s disease.

    Brian J. Tabner;Stuart Turnbull;Omar M.A. El-Agnaf;David Allsop

  • Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α‐synuclein protein implicated in Parkinson's disease

    Omar M.A El-Agnaf;Ross Jakes;Martin D Curran;Andrew Wallace

  • Hydrogen Peroxide Is Generated during the Very Early Stages of Aggregation of the Amyloid Peptides Implicated in Alzheimer Disease and Familial British Dementia

    Brian J. Tabner;Omar M.A. El-Agnaf;Omar M.A. El-Agnaf;Stuart Turnbull;Matthew J. German

  • Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.

    Lucilla Parnetti;Davide Chiasserini;Emanuele Persichetti;Paolo Eusebi

  • Oligomerization and Toxicity of β-Amyloid-42 Implicated in Alzheimer's Disease

    Omar M.A. El-Agnaf;Devinder S. Mahil;Bhroma P. Patel;Brian M. Austen

  • Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases.

    Brian J. Tabner;Stuart Turnbull;Omar M.A. El-Agnaf;David Allsop

  • Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease

    Nour K. Majbour;Nour K. Majbour;Nishant N. Vaikath;Nishant N. Vaikath;Karin D. van Dijk;Mustafa T. Ardah

  • Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies

    Katerina E Paleologou;Christine L Kragh;David M A Mann;Sultan A Salem

  • Cerebrospinal fluid biomarkers in Parkinson disease.

    Lucilla Parnetti;Anna Castrioto;Davide Chiasserini;Emanuele Persichetti

  • α-synuclein implicated in Parkinson’s disease catalyses the formation of hydrogen peroxide in vitro.

    Stuart Turnbull;Brian J Tabner;Omar M.A El-Agnaf;Susan Moore

  • A strategy for designing inhibitors of α -synuclein aggregation and toxicity as a novel treatment for Parkinson's disease and related disorders

    Omar M. A. El-Agnaf;Katerina E. Paleologou;Brett Greer;Abdulmawala M. Abogrein

Frequent Co-Authors

David Allsop
David Allsop Lancaster University
Brit Mollenhauer
Brit Mollenhauer University of Göttingen
Tiago F. Outeiro
Tiago F. Outeiro University of Göttingen
Lucilla Parnetti
Lucilla Parnetti University of Perugia
Derek Middleton
Derek Middleton University of Liverpool
Francis Martin
Francis Martin University of Lorraine
Hilal A. Lashuel
Hilal A. Lashuel École Polytechnique Fédérale de Lausanne
Paolo Calabresi
Paolo Calabresi Catholic University of the Sacred Heart
Jose A. Obeso
Jose A. Obeso CEU San Pablo University

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