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Poul Henning Jensen

Poul Henning Jensen

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
15598
World Ranking
7837
National Ranking
74

Overview

Poul Henning Jensen is affiliated with Aarhus University in Denmark and has built an extensive research portfolio primarily focusing on medicine and neuroscience. Their work spans multiple subfields including neurology, cellular and molecular neuroscience, physiology, molecular biology, and cell biology.

The primary topics of their research involve Parkinson's disease mechanisms and treatments, neurological disorders and treatments more broadly, Alzheimer's disease research and treatments, nuclear receptors and signaling, genetic neurodegenerative diseases, botulinum toxin and related neurological disorders, and neuroinflammation and neurodegeneration mechanisms.

They have published numerous papers in notable venues with recurring contributions to bioRxiv (Cold Spring Harbor Laboratory), npj Parkinson's Disease, Acta Neuropathologica Communications, Acta Neuropathologica, and Movement Disorders.

Recent publications by Poul Henning Jensen include:

  • "α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity" (2022, Proceedings of the National Academy of Sciences)
  • "Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease" (2021, npj Parkinson's Disease)
  • "Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats" (2021, Brain)
  • "The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses" (2021, International Journal of Molecular Sciences)
  • "Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential" (2021, Acta Neuropathologica)

Throughout their career, Poul Henning Jensen has collaborated frequently with other researchers. Common co-authors include Hjalte Gram, Nanna Møller Jensen, Lasse Reimer, Cristine Betzer, and Nelson Ferreira.

Best Publications

  • Structural and functional characterization of two alpha-synuclein strains

    Luc Bousset;Laura Pieri;Gemma Ruiz-Arlandis;Julia Gath

  • DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease

    Zhen Hong;Min Shi;Kathryn A. Chung;Joseph F. Quinn

  • Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

    Poul H. Jensen;Morten S. Nielsen;Ross Jakes;Carlos G. Dotti

  • Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

    A Nykjaer;C M Petersen;B Møller;P H Jensen

  • Proteasomal Inhibition by α-Synuclein Filaments and Oligomers

    Evo Lindersson;Rasmus Beedholm;Peter Højrup;Torben Moos

  • α-Synuclein Binds to Tau and Stimulates the Protein Kinase A-catalyzed Tau Phosphorylation of Serine Residues 262 and 356

    Poul Henning Jensen;Henrik Hager;Morten S. Nielsen;Peter Højrup

  • Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

    Emanuela Colla;Poul H. Jensen;Olga Pletnikova;Juan C. Troncoso

  • In Situ and in Vitro Study of Colocalization and Segregation of α-Synuclein, Ubiquitin, and Lipids in Lewy Bodies

    W.P. Gai;H.X. Yuan;X.Q. Li;J.T.H. Power

  • Phosphorylated α-Synuclein in Parkinson’s Disease

    Yu Wang;Min Shi;Kathryn A. Chung;Cyrus P. Zabetian

  • Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.

    Nathalie Van Den Berge;Nathalie Van Den Berge;Nelson Ferreira;Hjalte Gram;Trine Werenberg Mikkelsen

  • Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.

    Edward Rockenstein;Silke Nuber;Cassia R. Overk;Kiren Ubhi

  • α-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease

    Glenda M. Halliday;Anita Ophof;Melissa Broe;Poul H. Jensen

  • Detection of elevated levels of soluble α-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies

    Katerina E Paleologou;Christine L Kragh;David M A Mann;Sultan A Salem

  • Phosphorylated a-Synuclein in Parkinson's Disease

    Yu Wang;Min Shi;Kathryn A. Chung;Cyrus P. Zabetian

  • Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

    Patrick Ejlerskov;Izabela Rasmussen;Troels Tolstrup Nielsen;Troels Tolstrup Nielsen;Ann-Louise Bergström

  • How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicity in Vitro

    Nikolai Lorenzen;Søren B. Nielsen;Yuichi Yoshimura;Brian S. Vad

  • Calcium(II) selectively induces α‐synuclein annular oligomers via interaction with the C‐terminal domain

    Rachel Lowe;Dean Louis Pountney;Poul Henning Jensen;Wei Ping Gai

  • p25α Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy

    Yun Ju C. Song;Ditte M.S. Lundvig;Yue Huang;Wei Ping Gai

  • p25α Stimulates α-Synuclein Aggregation and Is Co-localized with Aggregated α-Synuclein in α-Synucleinopathies

    Evo Lindersson;Ditte Lundvig;Christine Petersen;Peder Madsen

  • Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC.

    Poul H. Jensen;Peter Højrup;Henrik Hager;Morten S. Nielsen

Frequent Co-Authors

Jørgen Gliemann
Jørgen Gliemann Aarhus University
Glenda M. Halliday
Glenda M. Halliday University of Sydney
Daniel E. Otzen
Daniel E. Otzen Aarhus University
Peter Højrup
Peter Højrup University of Southern Denmark
Cyrus P. Zabetian
Cyrus P. Zabetian University of Washington
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Deniz Kirik
Deniz Kirik Lund University
James B. Leverenz
James B. Leverenz Cleveland Clinic
Torben Moos
Torben Moos Aalborg University
Peter A. Andreasen
Peter A. Andreasen Aarhus University

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