World's Best Scientists 2026 revealed!
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Microbiology
USA
2026

D-Index & Metrics

Microbiology

D-Index
115
Citations
67720
World Ranking
187
National Ranking
84

Research.com Recognitions

  • 2026 - Research.com Microbiology in United States Leader Award
  • 2025 - Research.com Microbiology in United States Leader Award

Overview

Alan Aderem is affiliated with Seattle Children's Hospital in the United States. Their research primarily focuses on Immunology and Microbiology, with significant contributions to Medicine as well. Within these broader fields, their subfields of study include Immunology, Infectious Diseases, Molecular Biology, Epidemiology, and Virology.

The scientist's work involves several main topics, reflecting a broad interest in immune mechanisms and infectious agents. These topics include:

  • Immune Response and Inflammation
  • Immune cells in cancer
  • Tuberculosis Research and Epidemiology
  • Mycobacterium research and diagnosis
  • Interferon and immune responses
  • Immune responses and vaccinations
  • COVID-19 Clinical Research Studies

Alan Aderem has published multiple recent papers. Notable works include:

  • "Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19," 2020, published in Cell
  • "Type I interferon decreases macrophage energy metabolism during mycobacterial infection," 2021, published in Cell Reports
  • "Contained Mycobacterium tuberculosis infection induces concomitant and heterologous protection," 2020, published in PLoS Pathogens
  • "Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection," 2024, published in PLoS Pathogens
  • "A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV," 2020, published in Cell Reports

The scientist collaborates frequently with a number of colleagues, including:

  • Alan H. Diercks (28 co-publications)
  • Dat Mai (23 co-publications)
  • Alissa C. Rothchild (22 co-publications)
  • Ana N. Jahn (21 co-publications)
  • Elizabeth S. Gold (20 co-publications)

Their research has appeared in a variety of publication venues. The most frequent among these include:

  • OPAL (Open@LaTrobe) (La Trobe University) with 12 publications
  • bioRxiv (Cold Spring Harbor Laboratory) with 5 publications
  • PLoS Pathogens with 3 publications
  • Cell Reports with 2 publications
  • The Journal of Immunology with 2 publications

Best Publications

  • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5.

    Fumitaka Hayashi;Kelly D. Smith;Adrian Ozinsky;Thomas R. Hawn;Thomas R. Hawn

  • Toll-like receptors in the induction of the innate immune response

    Alan Aderem;Richard J. Ulevitch

  • MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES

    Alan Aderem;David M. Underhill

  • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

    Adrian Ozinsky;David M. Underhill;Jason D. Fontenot;Adeline M. Hajjar

  • Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron.

    Trude H Flo;Kelly D Smith;Kelly D Smith;Shintaro Sato;David J Rodriguez

  • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens

    David M. Underhill;Adrian Ozinsky;Adeline M. Hajjar;Anne Stevens

  • Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

    Edward A Miao;Irina A Leaf;Piper M Treuting;Dat P Mao

  • The evolution of vertebrate Toll-like receptors

    Jared C. Roach;Gustavo Glusman;Lee Rowen;Amardeep Kaur

  • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

    Edward A Miao;Celia M Alpuche-Aranda;Monica Dors;April E Clark

  • Caspase-1-induced pyroptotic cell death.

    Edward A. Miao;Jayant V. Rajan;Jayant V. Rajan;Alan Aderem

  • Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

    Troy D Querec;Rama Akondy;Eva K Lee;Weiping Cao

  • Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages.

    David M. Underhill;Adrian Ozinsky;Kelly D. Smith;Alan Aderem

  • Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility.

    Kelly D Smith;Kelly D Smith;Erica Andersen-Nissen;Erica Andersen-Nissen;Fumitaka Hayashi;Fumitaka Hayashi;Fumitaka Hayashi;Katie Strobe

  • Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

    John W. Schoggins;Donna A. MacDuff;Naoko Imanaka;Maria D. Gainey

  • Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

    Catherine Werts;Catherine Werts;Richard I. Tapping;John C. Mathison;Tsung Hsien Chuang

  • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

    Edward A. Miao;Dat P. Mao;Natalya Yudkovsky;Richard Bonneau

  • Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4

    Mark Gilchrist;Vesteinn Thorsson;Bin Li;Alistair G. Rust

  • Systems biology of vaccination for seasonal influenza in humans

    Helder Imoto Nakaya;Jens Wrammert;Eva K Lee;Luigi Racioppi;Luigi Racioppi

  • MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin.

    J. H. Hartwig;M. Thelen;M. Thelen;A. Resen;P. A. Janmey

  • The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

    Stuart McLaughlin;Alan Aderem

Frequent Co-Authors

Kelly D. Smith
Kelly D. Smith University of Washington
Thomas R. Hawn
Thomas R. Hawn University of Washington
Edward A. Miao
Edward A. Miao University of North Carolina at Chapel Hill
David M. Underhill
David M. Underhill Cedars-Sinai Medical Center
Zanvil A. Cohn
Zanvil A. Cohn Rockefeller University
John D. Aitchison
John D. Aitchison University of Minnesota
Angus C. Nairn
Angus C. Nairn Yale University
Lee-Ann H. Allen
Lee-Ann H. Allen University of Iowa
Bali Pulendran
Bali Pulendran Stanford University
Leroy Hood
Leroy Hood University of Washington

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