World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
103
Citations
37787
World Ranking
645
National Ranking
375

Medicine

D-Index
103
Citations
38882
World Ranking
7369
National Ranking
3856

Overview

Andrew T. Gewirtz is affiliated with Georgia State University in the United States. Their research primarily centers on the intersection of gut microbiota, health, and disease processes, with a strong focus on molecular biology and infectious diseases within the medical sciences.

Their recent publications include studies addressing the complex interactions between gut bacteria and host metabolism, dietary impacts on gut microbiota, and microbial influences on gastrointestinal conditions. Notable papers include:

  • Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity (2022, Nature Microbiology)
  • Sphingolipids produced by gut bacteria enter host metabolic pathways impacting ceramide levels (2020, Nature Communications)
  • Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome (2021, Gastroenterology)
  • Direct impact of commonly used dietary emulsifiers on human gut microbiota (2021, Microbiome)
  • Considering gut microbiota in treatment of type 2 diabetes mellitus (2020, Gut Microbes)

The scientist has frequently co-authored works with several collaborators, including Benoît Chassaing, Vu L. Ngo, Jun Zou, Alexis Bretin, and Yanling Wang. These partnerships have contributed to a substantial body of research advancing knowledge in gut microbiota and related fields.

Gewirtz's work has been published in various venues with Gastroenterology being the most frequent outlet, followed by bioRxiv (Cold Spring Harbor Laboratory), Gut Microbes, Current Developments in Nutrition, and Cellular and Molecular Gastroenterology and Hepatology. This distribution highlights a consistent engagement with journals focused on gastrointestinal and microbiological research.

Their research spans multiple fields of study, primarily Medicine and Biochemistry, Genetics, and Molecular Biology. Subfields include Molecular Biology, Infectious Diseases, Physiology, Epidemiology, and Immunology. This interdisciplinary approach facilitates a comprehensive examination of gut microbiota's roles in health and disease.

Key topics addressed in Gewirtz's research are:

  • Gut microbiota and health
  • Clostridium difficile and Clostridium perfringens research
  • Diet and metabolism studies
  • Gastrointestinal motility and disorders
  • Nutritional studies and diet
  • Viral gastroenteritis research and epidemiology
  • Immune responses and vaccinations

Best Publications

  • Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

    Matam Vijay-Kumar;Jesse D. Aitken;Frederic A. Carvalho;Tyler C. Cullender

  • Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

    Benoit Chassaing;Omry Koren;Julia K. Goodrich;Angela C. Poole

  • Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

    Andrew T. Gewirtz;Tony A. Navas;Sean Lyons;Paul J. Godowski

  • Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

    Andrew S. Neish;Andrew T. Gewirtz;Hui Zeng;Andrew N. Young

  • Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

    Malin E V Johansson;Jenny K Gustafsson;Jessica Holmén-Larsson;Karolina S Jabbar

  • Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging

    Mary Renshaw;Julie Rockwell;Carrie Engleman;Andrew Gewirtz

  • Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

    Jau-Yi Li;Benoit Chassaing;Abdul Malik Tyagi;Chiara Vaccaro

  • Dysregulation of Inflammatory Responses by Chronic Circadian Disruption

    Oscar Castanon-Cervantes;Mingwei Wu;J. Christopher Ehlen;Ketema Paul

  • Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

    Frederic A. Carvalho;Frederic A. Carvalho;Frederic A. Carvalho;Omry Koren;Julia K. Goodrich;Malin E.V. Johansson

  • Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation.

    Benoit Chassaing;Gayathri Srinivasan;Maria A. Delgado;Andrew N. Young

  • Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation

    Benoit Chassaing;Tom Van de Wiele;Jana De Bodt;Massimo Marzorati

  • Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.

    Amal Amer;Luigi Franchi;Thirumala Devi Kanneganti;Mathilde Body-Malapel

  • Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health.

    Jun Zou;Benoit Chassaing;Vishal Singh;Michael Pellizzon

  • Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans.

    Thomas Hagan;Mario Cortese;Nadine Rouphael;Carolyn Boudreau

  • TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.

    Jason Z. Oh;Rajesh Ravindran;Benoit Chassaing;Frederic A. Carvalho;Frederic A. Carvalho

  • Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response

    Andrew T. Gewirtz;Peter O. Simon;Clare K. Schmitt;Laura J. Taylor

  • Deletion of TLR5 results in spontaneous colitis in mice.

    Matam Vijay-Kumar;Catherine J. Sanders;Rebekah T. Taylor;Amrita Kumar

  • Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.

    Vishal Singh;Beng San Yeoh;Benoit Chassaing;Xia Xiao

  • Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling.

    Mallappa Anitha;Matam Vijay–Kumar;Shanthi V. Sitaraman;Andrew T. Gewirtz

  • Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut

    Tyler C. Cullender;Benoit Chassaing;Anders Janzon;Krithika Kumar

Frequent Co-Authors

Benoit Chassaing
Benoit Chassaing Georgia State University
Matam Vijay-Kumar
Matam Vijay-Kumar University of Toledo
Didier Merlin
Didier Merlin Georgia State University
Shanthi V. Sitaraman
Shanthi V. Sitaraman Emory University
Andrew S. Neish
Andrew S. Neish Emory University
James L. Madara
James L. Madara American Medical Association
Ruth E. Ley
Ruth E. Ley Max Planck Society
Christopher Duggan
Christopher Duggan Boston Children's Hospital
Lixin Wang
Lixin Wang Indiana University – Purdue University Indianapolis
Timothy L. Denning
Timothy L. Denning Georgia Research Alliance

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