World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
19090
World Ranking
9499
National Ranking
4194

Overview

Matam Vijay-Kumar is affiliated with the University of Toledo in the United States and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans a range of interconnected topics including gut microbiota and health, diet and metabolism studies, liver disease diagnosis and treatment, as well as neurobiological aspects related to tryptophan and brain disorders.

The scientist's work is characterized by a multidisciplinary approach that integrates molecular biology, physiology, immunology, genetics, and epidemiology. This diverse expertise supports investigations into the interactions between the gut microbiome and host immunity, metabolic regulation, and disease mechanisms.

Their publication record features several recent papers addressing key areas of immune system function, microbial influences, and metabolic regulation. Notable recent publications include:

  • "Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy," 2023, Biomedicines
  • "Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease," 2020, Physiological Genomics
  • "Gnotobiotic Rats Reveal That Gut Microbiota Regulates Colonic mRNA of Ace2, the Receptor for SARS-CoV-2 Infectivity," 2020, Hypertension
  • "Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator," 2021, JCI Insight
  • "Microbiota Introduced to Germ-Free Rats Restores Vascular Contractility and Blood Pressure," 2020, Hypertension

Matam Vijay-Kumar frequently collaborates with a number of researchers, with co-authors including Beng San Yeoh, Bina Joe, Piu Saha, Rachel M. Golonka, and Blair Mell. Their work has also appeared recurrently in several scientific venues, such as:

  • Hypertension
  • The FASEB Journal
  • Physiology
  • Physiological Genomics
  • Gut Microbes

The major research topics reflected throughout their publications include:

  • Gut microbiota and health
  • Diet and metabolism studies
  • Liver Disease Diagnosis and Treatment
  • Diet, Metabolism, and Disease
  • Tryptophan and brain disorders
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Immune cells in cancer

Matam Vijay-Kumar's research contributes to understanding complex biological systems underlying inflammatory responses, metabolic disorders, and infectious diseases. Their interdisciplinary focus bridges molecular biology and clinical relevance, aiming to clarify how microbial communities and immune signaling affect health and disease outcomes.

Best Publications

  • Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

    Matam Vijay-Kumar;Jesse D. Aitken;Frederic A. Carvalho;Tyler C. Cullender

  • Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

    Benoit Chassaing;Jesse D. Aitken;Madhu Malleshappa;Matam Vijay-Kumar

  • Biological Properties of Curcumin-Cellular and Molecular Mechanisms of Action

    Bina Joe;M. Vijaykumar;B. R. Lokesh

  • Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

    Rajbir Singh;Sandeep Chandrashekharappa;Sobha R. Bodduluri;Becca V. Baby

  • Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

    Frederic A. Carvalho;Frederic A. Carvalho;Frederic A. Carvalho;Omry Koren;Julia K. Goodrich;Malin E.V. Johansson

  • Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation.

    Benoit Chassaing;Gayathri Srinivasan;Maria A. Delgado;Andrew N. Young

  • Deletion of TLR5 results in spontaneous colitis in mice.

    Matam Vijay-Kumar;Catherine J. Sanders;Rebekah T. Taylor;Amrita Kumar

  • Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.

    Vishal Singh;Beng San Yeoh;Benoit Chassaing;Xia Xiao

  • Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling.

    Mallappa Anitha;Matam Vijay–Kumar;Shanthi V. Sitaraman;Andrew T. Gewirtz

  • Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut

    Tyler C. Cullender;Benoit Chassaing;Anders Janzon;Krithika Kumar

  • Evidence for a link between gut microbiota and hypertension in the Dahl rat

    Blair Mell;Venkatakrishna R. Jala;Anna V. Mathew;Jaeman Byun

  • Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP.

    Florencia E Castaneda;Baljit Walia;Matam Vijay-Kumar;Neal R Patel

  • Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.

    Xia Xiao;Beng San Yeoh;Matam Vijay-Kumar

  • Flagellin Treatment Protects against Chemicals, Bacteria, Viruses, and Radiation

    Matam Vijay-Kumar;Jesse D. Aitken;Catherine J. Sanders;Amena Frias

  • Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18

    Benyue Zhang;Benoit Chassaing;Zhenda Shi;Robin Uchiyama

  • Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease.

    Andrew T. Gewirtz;Matam Vijay-Kumar;Steven R. Brant;Richard H. Duerr

  • Microbiota fermentation-NLRP3 axis shapes the impact of dietary fibres on intestinal inflammation

    Vishal Singh;Beng San Yeoh;Rachel E Walker;Xia Xiao

  • Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!

    Frederic A. Carvalho;Jesse D. Aitken;Matam Vijay-Kumar;Andrew T. Gewirtz

  • Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis.

    Pallavi Garg;Matam Vijay-Kumar;Lixin Wang;Andrew T. Gewirtz

  • TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin

    Matam Vijay-Kumar;Frederic A. Carvalho;Jesse D. Aitken;Nimita H. Fifadara

Frequent Co-Authors

Andrew T. Gewirtz
Andrew T. Gewirtz Georgia State University
Benoit Chassaing
Benoit Chassaing Georgia State University
Shanthi V. Sitaraman
Shanthi V. Sitaraman Emory University
Andrew S. Neish
Andrew S. Neish Emory University
Didier Merlin
Didier Merlin Georgia State University
Andrew D. Patterson
Andrew D. Patterson Pennsylvania State University
Rob Knight
Rob Knight University of California, San Diego
Dean P. Jones
Dean P. Jones Emory University
Ruth E. Ley
Ruth E. Ley Max Planck Society
Bodduluri Haribabu
Bodduluri Haribabu University of Louisville

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