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Neuroscience

D-Index
43
Citations
8040
World Ranking
7366
National Ranking
336

Overview

Guy Simonnet is affiliated with the University of Bordeaux in France and works primarily in the fields of Chemistry and Biochemistry, Genetics and Molecular Biology. Their research encompasses both broad and specialized areas, with significant contributions in Organic Chemistry, Molecular Biology, Cellular and Molecular Neuroscience, Cell Biology, and Rheumatology.

Their work covers a variety of main topics including receptor mechanisms and signaling, neuropeptides and animal physiology, chemical synthesis and analysis, chemical synthesis and reactions, catalytic cross-coupling reactions, catalytic C-H functionalization methods, and folate and B vitamins research.

Simonnet has published research in several peer-reviewed journals. Frequent publication venues include:

  • ChemMedChem
  • Journal of Medicinal Chemistry
  • RSC Medicinal Chemistry
  • Organic Process Research & Development
  • ACS Catalysis

They have collaborated frequently with several co-authors, notably Martine Schmitt and Séverine Schneider, each with eight joint publications, followed by Gaëlle Friocourt and Cécile Voisset with five appearances each, and Maha Sinane with four.

Selected recent papers by Guy Simonnet are:

  • Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors, 2021, RSC Medicinal Chemistry
  • Minimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions, 2020, Organic Process Research & Development
  • Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation, 2021, Neurotherapeutics
  • In Situ Formation of Cationic π-Allylpalladium Precatalysts in Alcoholic Solvents: Application to C-N Bond Formation, 2021, ACS Catalysis
  • Identification of an N-acylated-DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia, 2021, Journal of Medicinal Chemistry

Best Publications

  • Long-lasting Hyperalgesia Induced by Fentanyl in Rats: Preventive Effect of Ketamine

    Evelyne Célèrier;Cyril Rivat;Yan Jun;Jean Paul Laulin

  • The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance.

    Jean-Paul Laulin;Pierre Maurette;Jean-Benoît Corcuff;Cyril Rivat

  • Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process.

    Evelyne Célèrier;Jean-Paul Laulin;Jean-Benoı̂t Corcuff;Michel Le Moal

  • Opioid-induced hyperalgesia: abnormal or normal pain?

    Guy Simonnet;Cyril Rivat

  • RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia

    Frédéric Simonin;Martine Schmitt;Jean-Paul Laulin;Emilie Laboureyras

  • Evidence for opiate-activated NMDA processes masking opiate analgesia in rats.

    Evelyne Célèrier;Jean-Paul Laulin;Agnès Larcher;Michel Le Moal

  • Acute tolerance associated with a single opiate administration: involvement of N-methyl-D-aspartate-dependent pain facilitatory systems

    A Larcher;J.P Laulin;E Celerier;M Le Moal

  • Fentanyl enhancement of carrageenan-induced long-lasting hyperalgesia in rats: prevention by the N-methyl-D-aspartate receptor antagonist ketamine.

    Cyril Rivat;Jean Paul Laulin;Jean Benot Corcuff;Evelyne Célèrier

  • Supplementing desflurane-remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgesic requirements.

    Bruno Guignard;Carole Coste;Hélène Costes;Daniel I. Sessler

  • Opiate tolerance to daily heroin administration: an apparent phenomenon associated with enhanced pain sensitivity.

    J.P Laulin;E Célèrier;A Larcher;M Le Moal

  • Characterization of rat spinal cord receptors to FLFQPQRFamide, a mammalian morphine modulating peptide: a binding study.

    M. Allard;S. Geoffre;P. Legendre;J.D. Vincent

  • Long‐lasting increased pain sensitivity in rat following exposure to heroin for the first time

    Jean‐Paul Laulin;Agnès Larcher;Evelyne Célèrier;Michel Le Moal

  • Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats.

    Philippe Richebé;Cyril Rivat;Jean Paul Laulin;Pierre Maurette

  • Non-nociceptive Environmental Stress Induces Hyperalgesia, Not Analgesia, in Pain and Opioid-Experienced Rats

    Cyril Rivat;Emilie Laboureyras;Jean Paul Laulin;Chloé Le Roy

  • Nitrous oxide revisited: evidence for potent antihyperalgesic properties.

    Philippe Richebé;Cyril Rivat;Cyril Creton;Jean Paul Laulin

  • Autoradiographic distribution of receptors to FLFQPQRFamide, a morphine-modulating peptide, in rat central nervous system.

    M. Allard;J.-M. Zajac;G. Simonnet

  • Differential interactions of cholecystokinin and FLFQPQRF-NH2 with μ and δ opioid antinociception in the rat spinal cord

    D. S. K. Magnuson;A. F. Sullivan;G. Simonnet;B. P. Roques

  • Analogues of F8Famide resistant to degradation, with high affinity and in vivo effects.

    Sophie Gicquel;Honoré Mazarguil;Michelle Allard;Guy Simonnet

  • Characterization and localization of a putative morphine-modulating peptide, FLFQPQRFamide, in the rat spinal cord: biochemical and immunocytochemical studies.

    M. Allard;D.T. Theodosis;P. Rousselot;M.C. Lombard

  • Effect of nerve activity on the in vivo release of [3H]serotonin continuously formed from L-[3H]tryptophan in the caudate nucleus of the cat.

    F. He´nry;G. Simonnet;S. Bourgoin;P. Soubrie

Frequent Co-Authors

Michèle Allard
Michèle Allard Centre national de la recherche scientifique, CNRS
Jean-Didier Vincent
Jean-Didier Vincent Centre national de la recherche scientifique, CNRS
Jean-Marie Zajac
Jean-Marie Zajac Federal University of Toulouse Midi-Pyrénées
M. Le Moal
M. Le Moal University of Bordeaux
Pascal Legendre
Pascal Legendre Université Paris Cité
François Cesselin
François Cesselin Grenoble Alpes University
Dionysia T. Theodosis
Dionysia T. Theodosis Grenoble Alpes University
Martine Cador
Martine Cador University of Bordeaux
Florence Noble
Florence Noble Université Paris Cité

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