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Medicine

D-Index
127
Citations
55029
World Ranking
2848
National Ranking
1585

Research.com Recognitions

  • 1995 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Frank Porreca is affiliated with the University of Arizona in the United States. Their research is primarily situated within the field of Medicine, with specific focus on subfields such as Pharmacology, Physiology, Molecular Biology, Cellular and Molecular Neuroscience, and Neurology.

Their recent publications address various aspects of pain mechanisms and treatments, neuropeptides, cytokine signaling pathways, and musculoskeletal conditions. Notable recent papers include:

  • The Jak/STAT pathway: A focus on pain in rheumatoid arthritis (2020, Seminars in Arthritis and Rheumatism)
  • Green Light Exposure Improves Pain and Quality of Life in Fibromyalgia Patients: A Preliminary One-Way Crossover Clinical Trial (2020, Pain Medicine)
  • Conotoxin contulakin-G engages a neurotensin receptor 2/R-type calcium channel (Cav2.3) pathway to mediate spinal antinociception (2021, Pain)
  • Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism (2021, Biomedicines)
  • Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain (2024, bioRxiv (Cold Spring Harbor Laboratory))

The main topics covered by their work include:

  • Pain Mechanisms and Treatments
  • Neuropeptides and Animal Physiology
  • Pharmacological Effects of Natural Compounds
  • Cytokine Signaling Pathways and Interactions
  • Rheumatoid Arthritis Research and Therapies
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Musculoskeletal pain and rehabilitation

Frank Porreca has frequently collaborated with researchers including Laurent Martin, Rajesh Khanna, Mohab Ibrahim, Amol Patwardhan, and Kimberly Gómez. These collaborations reflect a blend of expertise contributing to multiple dimensions of pain research and neuropharmacology.

Their work has been published across several venues, notably Seminars in Arthritis and Rheumatism, Pain Medicine, Pain, BioRxiv (Cold Spring Harbor Laboratory), and Biomedicines.

In recognition of their scientific contributions, Frank Porreca was awarded the status of Fellow of the American Association for the Advancement of Science (AAAS) in 1995.

Best Publications

  • Central modulation of pain

    Michael H. Ossipov;Gregory O. Dussor;Frank Porreca

  • Chronic pain and medullary descending facilitation

    Frank Porreca;Michael H Ossipov;G.F Gebhart

  • Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

    Claes R Wahlestedt;Peter Salmi;Liam Good;Johanna Kela

  • Descending pain modulation and chronification of pain.

    Michael H. Ossipov;Kozo Morimura;Frank Porreca

  • CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.

    Mohab M. Ibrahim;Frank Porreca;Josephine Lai;Phillip J. Albrecht

  • Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

    Mohab M. Ibrahim;Hongfeng Deng;Alexander Zvonok;Debra A. Cockayne

  • Unmasking the tonic-aversive state in neuropathic pain.

    Tamara King;Louis Vera-Portocarrero;Tannia Gutierrez;Todd W Vanderah

  • Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8.

    Josephine Lai;Michael S Gold;Chang Sook Kim;Di Bian

  • Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

    F Porreca;H I Mosberg;R Hurst;V J Hruby

  • CB2 cannabinoid receptor-mediated peripheral antinociception.

    T.Philip Malan;Mohab M. Ibrahim;Hongfeng Deng;Qian Liu

  • Reward and motivation in pain and pain relief

    Edita Navratilova;Frank Porreca

  • A Comparison of the Potential Role of the Tetrodotoxin-Insensitive Sodium Channels, PN3/SNS and NaN/SNS2, in Rat Models of Chronic Pain

    Frank Porreca;Josephine Lai;D. I. Bian;Sandra Wegert

  • Statistical analysis of drug-drug and site-site interactions with isobolograms.

    Ronald J. Tallarida;Frank Porreca;Alan Cowan

  • A Newly Identified Role for Superoxide in Inflammatory Pain

    Zhi Qiang Wang;Frank Porreca;Salvatore Cuzzocrea;Karen Galen

  • Redistribution of NaV1.8 in Uninjured Axons Enables Neuropathic Pain

    Michael S. Gold;Daniel Weinreich;Chang Sook Kim;Ruizhong Wang

  • AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties

    Narender R. Gavva;Rami Tamir;Yusheng Qu;Lana Klionsky

  • The rat paw formalin test: comparison of noxious agents.

    Helen Wheeler-Aceto;Frank Porreca;Frank Porreca;Alan Cowan

  • The role of sodium channels in chronic inflammatory and neuropathic pain.

    Ron Amir;Charles E. Argoff;Gary J. Bennett;Theodore R. Cummins

  • Molecular Determinants of Vanilloid Sensitivity in TRPV1

    Narender R. Gavva;Lana Klionsky;Yusheng Qu;Licheng Shi

  • Voltage-Gated Sodium Channels and Hyperalgesia

    Josephine Lai;Frank Porreca;John C. Hunter;Michael S. Gold

Frequent Co-Authors

Victor J. Hruby
Victor J. Hruby University of Arizona
Michael H. Ossipov
Michael H. Ossipov University of Arizona
Todd W. Vanderah
Todd W. Vanderah University of Arizona
Henry I. Yamamura
Henry I. Yamamura University of Arizona
Tamara King
Tamara King University of New England
T. Philip Malan
T. Philip Malan University of Arizona
Richard B. Rothman
Richard B. Rothman National Institute on Drug Abuse
Kenner C. Rice
Kenner C. Rice National Institutes of Health
David W. Dodick
David W. Dodick Mayo Clinic
Henry I. Mosberg
Henry I. Mosberg University of Michigan–Ann Arbor

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