D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 98 Citations 39,552 761 World Ranking 524 National Ranking 244
Biology and Biochemistry D-index 92 Citations 37,408 636 World Ranking 975 National Ranking 594

Research.com Recognitions

Awards & Achievements

2019 - Fellow, National Academy of Inventors

1984 - Fellow of John Simon Guggenheim Memorial Foundation

1971 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Internal medicine
  • Organic chemistry

Victor J. Hruby spends much of his time researching Stereochemistry, Receptor, Internal medicine, Endocrinology and Enkephalin. Victor J. Hruby has included themes like Amino acid, Ligand, μ-opioid receptor, Side chain and Peptide in his Stereochemistry study. Biochemistry covers he research in Receptor.

His Internal medicine study frequently draws connections to adjacent fields such as Potency. His Enkephalin study combines topics in areas such as -Naloxone, δ-opioid receptor, Opioid peptide and Blood–brain barrier. His biological study spans a wide range of topics, including Glycopeptide, Pharmacology and Nociception.

His most cited work include:

  • A new type of synthetic peptide library for identifying ligand-binding activity (1864 citations)
  • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome (1683 citations)
  • Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors. (624 citations)

What are the main themes of his work throughout his whole career to date?

Stereochemistry, Receptor, Peptide, Internal medicine and Endocrinology are his primary areas of study. Within one scientific family, Victor J. Hruby focuses on topics pertaining to Amino acid under Stereochemistry, and may sometimes address concerns connected to Organic chemistry. His Receptor study contributes to a more complete understanding of Biochemistry.

His Peptide research incorporates elements of Combinatorial chemistry, Side chain, Pharmacophore and Ligand. He focuses mostly in the field of Glucagon, narrowing it down to matters related to Cyclase and, in some cases, Adenylate kinase. Victor J. Hruby combines subjects such as δ-opioid receptor and Opioid peptide with his study of Enkephalin.

He most often published in these fields:

  • Stereochemistry (39.21%)
  • Receptor (26.88%)
  • Peptide (21.67%)

What were the highlights of his more recent work (between 2009-2021)?

  • Receptor (26.88%)
  • Pharmacology (13.65%)
  • Stereochemistry (39.21%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Receptor, Pharmacology, Stereochemistry, Opioid and Melanocortin. His study in Receptor is interdisciplinary in nature, drawing from both Pharmacophore and Endocrinology. His Pharmacology research integrates issues from Opioid receptor, Antagonist, κ-opioid receptor, Central nervous system and Dynorphin A.

The study incorporates disciplines such as Amino acid, DAMGO, Molecule, Selectivity and Structure–activity relationship in addition to Stereochemistry. His research integrates issues of Analgesic, Neuropathic pain, Hyperalgesia and Chronic pain in his study of Opioid. In Melanocortin, Victor J. Hruby works on issues like Peptide, which are connected to Combinatorial chemistry.

Between 2009 and 2021, his most popular works were:

  • Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. (117 citations)
  • Multiple N-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies (67 citations)
  • Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. (50 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • Internal medicine

His primary areas of study are Receptor, Stereochemistry, Pharmacology, Opioid and Melanocortin. His studies link Pharmacophore with Receptor. His Stereochemistry research is multidisciplinary, relying on both Agonist, Amino acid, Structure–activity relationship and Peptide.

His work deals with themes such as Endocrinology, Antagonist, Bradykinin, Dynorphin and Internal medicine, which intersect with Pharmacology. The various areas that Victor J. Hruby examines in his Opioid study include Analgesic, Neuropathic pain and Hyperalgesia. His Melanocortin research is included under the broader classification of Biochemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A new type of synthetic peptide library for identifying ligand-binding activity

Kit S. Lam;Sydney E. Salmon;Evan M. Hersh;Victor J. Hruby.
Nature (1992)

2465 Citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

W. Fan;B. A. Boston;R. A. Kesterson;V. J. Hruby.
Nature (1997)

2267 Citations

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

Henry I. Mosberg;Robin Hurst;Victor J. Hruby;Kelvin Gee.
Proceedings of the National Academy of Sciences of the United States of America (1983)

986 Citations

Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof

Kit Sang Lam;Sydney E. Salmon;Victor J. Hruby;Evan M. Hersh.
(1991)

747 Citations

Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations.

V J Hruby;F al-Obeidi;W Kazmierski.
Biochemical Journal (1990)

727 Citations

Conformational restrictions of biologically active peptides via amino acid side chain groups

Victor J. Hruby.
Life Sciences (1982)

632 Citations

4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.

Tomi K. Sawyer;Pauline J. Sanfilippo;Victor J. Hruby;Michael H. Engel.
Proceedings of the National Academy of Sciences of the United States of America (1980)

596 Citations

The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

Jeffrey S. Mogil;Sonya G. Wilson;Elissa J. Chesler;Andrew L. Rankin.
Proceedings of the National Academy of Sciences of the United States of America (2003)

550 Citations

Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

F Porreca;H I Mosberg;R Hurst;V J Hruby.
Journal of Pharmacology and Experimental Therapeutics (1984)

535 Citations

Peptidomimetics, a synthetic tool of drug discovery

Josef Vagner;Hongchang Qu;Victor J Hruby.
Current Opinion in Chemical Biology (2008)

524 Citations

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