Victor J. Hruby

Research.com Recognitions

• 2019 - Fellow, National Academy of Inventors
• 1984 - Fellow of John Simon Guggenheim Memorial Foundation
• 1971 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• A new type of synthetic peptide library for identifying ligand-binding activity

  Kit S. Lam;Sydney E. Salmon;Evan M. Hersh;Victor J. Hruby

  2721
  Citations

• Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

  W. Fan;B. A. Boston;R. A. Kesterson;V. J. Hruby

  2454
  Citations

• Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

  Henry I. Mosberg;Robin Hurst;Victor J. Hruby;Kelvin Gee

  1028
  Citations

• Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations.

  V J Hruby;F al-Obeidi;W Kazmierski

  738
  Citations

• Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof

  Kit Sang Lam;Sydney E. Salmon;Victor J. Hruby;Evan M. Hersh

  727
  Citations

• Peptidomimetics, a synthetic tool of drug discovery

  Josef Vagner;Hongchang Qu;Victor J Hruby

  717
  Citations

• Conformational restrictions of biologically active peptides via amino acid side chain groups

  Victor J. Hruby

  679
  Citations

• 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.

  Tomi K. Sawyer;Pauline J. Sanfilippo;Victor J. Hruby;Michael H. Engel

  675
  Citations

• The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans

  Jeffrey S. Mogil;Sonya G. Wilson;Elissa J. Chesler;Andrew L. Rankin

  619
  Citations

• Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

  F Porreca;H I Mosberg;R Hurst;V J Hruby

  564
  Citations

• Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.

  Victor J Hruby;Dongsi Lu;Shubh D. Sharma;Ana L. De Castrucci

  537
  Citations

• Designing peptide receptor agonists and antagonists

  Victor J. Hruby

  518
  Citations

• Design of peptides, proteins, and peptidomimetics in chi space

  Victor J. Hruby;Guigen Li;Carrie Haskell-Luevano;Mark Shenderovich

  464
  Citations

• Activation of two signal-transduction systems in hepatocytes by glucagon

  Michael J. O. Wakelam;Gregory J. Murphy;Victor J. Hruby;Miles D. Houslay

  455
  Citations

• Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics.

  Fahad Al-Obeidi;Ana M. de L. Castrucci;Ana M. de L. Castrucci;Mac E. Hadley;Victor J. Hruby

  424
  Citations

• Pronociceptive actions of dynorphin maintain chronic neuropathic pain.

  Zaijie Wang;Luis R. Gardell;Michael H. Ossipov;Todd W. Vanderah

  361
  Citations

• Molecular biology and pharmacology of cloned opioid receptors.

  Richard J. Knapp;Ewa Malatynska;Nathan Collins;Lei Fang

  344
  Citations

• Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier.

  R Polt;F Porreca;L Z Szabò;E J Bilsky

  341
  Citations

• Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications.

  Ruben S Vardanyan;Victor J Hruby

  335
  Citations

• Structure-function relationships in glucagon: properties of highly purified des-His-1-, monoiodo-, and (des-Asn-28, Thr-29)(homoserine lactone-27)-glucagon.

  Michael C. Lin;David E. Wright;Victor J. Hruby;Martin Rodbell

  332
  Citations

• Erratum: A new type of synthetic peptide library for identifying ligand-binding activity (Nature (1991) 354 (82-84))

  Kit S. Lam;Sydney E. Salmon;Evan M. Hersh;Victor J. Hruby

  19
  Citations