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D-Index & Metrics

Chemistry

D-Index
64
Citations
15647
World Ranking
7994
National Ranking
2322

Research.com Recognitions

  • 2004 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Henry I. Mosberg is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily centers on biochemistry, genetics, and molecular biology, with a significant focus on neuroscience. The subfields that are pivotal in their work include molecular biology and cellular and molecular neuroscience.

The main research topics Henry I. Mosberg engages with involve receptor mechanisms and signaling, neuropeptides and animal physiology, as well as pharmacological receptor mechanisms and effects. These topics reflect an emphasis on understanding the molecular and cellular bases of receptor function and pharmacology.

Henry I. Mosberg has contributed to multiple scientific publications. Notable papers include:

  • "Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability" (2020), published in the Journal of Medicinal Chemistry
  • "SAR Matrices Enable Discovery of Mixed Efficacy μ-Opioid Receptor Agonist Peptidomimetics with Simplified Structures through an Aromatic-Amine Pharmacophore" (2020), published in ACS Chemical Neuroscience

The scientist frequently publishes in the following venues:

  • Journal of Medicinal Chemistry
  • ACS Chemical Neuroscience

Collaborations feature prominently in Henry I. Mosberg's research activities. Frequent coauthors include:

  • Sean Henry
  • Jessica P. Anand
  • Jack J. Twarozynski
  • Ashley C. Brinkel
  • John R. Traynor

Henry I. Mosberg was recognized with the title Fellow of the American Association for the Advancement of Science (AAAS) in 2004.

Best Publications

  • OPM database and PPM web server: resources for positioning of proteins in membranes

    Mikhail A. Lomize;Irina D. Pogozheva;Hyeon Joo;Henry I. Mosberg

  • OPM: Orientations of Proteins in Membranes database

    Mikhail A. Lomize;Andrei L. Lomize;Irina D. Pogozheva;Henry I. Mosberg

  • Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

    Henry I. Mosberg;Robin Hurst;Victor J. Hruby;Kelvin Gee

  • Roles of mu, delta and kappa opioid receptors in spinal and supraspinal mediation of gastrointestinal transit effects and hot-plate analgesia in the mouse.

    F Porreca;H I Mosberg;R Hurst;V J Hruby

  • Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.

    Q. Jiang;A. E. Takemori;M. Sultana;P. S. Portoghese

  • Lack of antinociceptive cross-tolerance between [D-Pen2, D-Pen5]enkephalin and [D-Ala2]deltorphin II in mice: evidence for delta receptor subtypes.

    A Mattia;T Vanderah;H I Mosberg;F Porreca

  • Positioning of proteins in membranes: a computational approach.

    Andrei L. Lomize;Irina D. Pogozheva;Mikhail A. Lomize;Henry I. Mosberg

  • Opioid receptor three-dimensional structures from distance geometry calculations with hydrogen bonding constraints.

    Irina D. Pogozheva;Andrei L. Lomize;Henry I. Mosberg

  • Direct dependence studies in rats with agents selective for different types of opioid receptor.

    A Cowan;X Z Zhu;H I Mosberg;J R Omnaas

  • Membrane Composition Determines Pardaxin's Mechanism of Lipid Bilayer Disruption

    Kevin J. Hallock;Dong Kuk Lee;John Omnaas;Henry I. Mosberg

  • Role of mu and delta receptors in the supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse.

    F Porreca;J S Heyman;H I Mosberg;J R Omnaas

  • Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors ALLOSTERIC MODULATION OF AGONIST BINDING BY Gi2

    Adam J. Kuszak;Sethuramasundaram Pitchiaya;Jessica P. Anand;Henry I. Mosberg

  • Cerebral delta opioid receptors mediate analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids.

    J J Galligan;H I Mosberg;R Hurst;V J Hruby

  • The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints

    Irina D. Pogozheva;Andrei L. Lomize;Henry I. Mosberg

  • Opioid δ-receptor involvement in supraspinal and spinal antinociception in mice

    Julius S. Heyman;Sheila A. Mulvaney;Henry I. Mosberg;Frank Porreca

  • Anisotropic solvent model of the lipid bilayer. 2. Energetics of insertion of small molecules, peptides, and proteins in membranes.

    Andrei L. Lomize;Irina D. Pogozheva;Henry I Mosberg

  • Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.

    S. D. Comer;E. M. Hoenicke;A. I. Sable;R. W. Mcnutt

  • The role of hydrophobic interactions in positioning of peripheral proteins in membranes

    Andrei L Lomize;Irina D Pogozheva;Mikhail A Lomize;Henry I Mosberg

  • Key Residues Defining the Μ-Opioid Receptor Binding Pocket: A Site-Directed Mutagenesis Study

    Alfred Mansour;Larry P. Taylor;Jeffrey L. Fine;Robert C. Thompson

  • Modulation of the potency and efficacy of mu-mediated antinociception by delta agonists in the mouse.

    J N Qi;H I Mosberg;F Porreca

Frequent Co-Authors

Victor J. Hruby
Victor J. Hruby University of Arizona
Frank Porreca
Frank Porreca University of Arizona
Richard R. Neubig
Richard R. Neubig Michigan State University
James H. Woods
James H. Woods University of Michigan–Ann Arbor
Philip S. Portoghese
Philip S. Portoghese University of Minnesota
Henry I. Yamamura
Henry I. Yamamura University of Arizona
Alvin H. Schmaier
Alvin H. Schmaier University Hospitals of Cleveland
Todd W. Vanderah
Todd W. Vanderah University of Arizona
Roger K. Sunahara
Roger K. Sunahara University of California, San Diego
James J. Galligan
James J. Galligan Michigan State University

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