2010 - Fellow of the American Chemical Society
1986 - Fellow of the American Association for the Advancement of Science (AAAS)
His primary areas of study are Pharmacology, Antagonist, Opioid, Opioid receptor and Stereochemistry. His Pharmacology study combines topics from a wide range of disciplines, such as -Naloxone, Narcotic antagonist, Naltrexone and Opiate. His work in the fields of Antagonist, such as Naltrindole, δ-opioid receptor and Competitive antagonist, overlaps with other areas such as Kappa.
His biological study spans a wide range of topics, including Endocrinology and Physical dependence. When carried out as part of a general Opioid receptor research project, his work on Norbinaltorphimine is frequently linked to work in Bivalent, therefore connecting diverse disciplines of study. His study in Stereochemistry is interdisciplinary in nature, drawing from both Structure–activity relationship, Opioid peptide and κ-opioid receptor.
His scientific interests lie mostly in Stereochemistry, Pharmacology, Receptor, Opioid and Opioid receptor. His research investigates the connection with Stereochemistry and areas like Opioid antagonist which intersect with concerns in Norbinaltorphimine. His Pharmacology research includes elements of Agonist, -Naloxone, μ-opioid receptor and Antagonist.
He interconnects Ligand and In vivo in the investigation of issues within Receptor. In his study, Enkephalin is strongly linked to Endocrinology, which falls under the umbrella field of Opioid. His research integrates issues of Competitive antagonist, Affinity label, Narcotic antagonist and Receptor antagonist in his study of Opioid receptor.
His main research concerns Pharmacology, Agonist, Opioid, Receptor and Opioid receptor. His Pharmacology study focuses on Morphine in particular. His studies in Agonist integrate themes in fields like Enzyme-linked receptor, Endocrinology, Receptor antagonist and Conditioned place preference.
His study looks at the relationship between Opioid and fields such as Antagonist, as well as how they intersect with chemical problems. His Receptor research is multidisciplinary, incorporating perspectives in Pharmacophore, Stereochemistry and In vivo. His Opioid receptor research integrates issues from Potency and δ-opioid receptor.
Opioid, Pharmacology, Agonist, Receptor and Opioid receptor are his primary areas of study. His studies in Pharmacology integrate themes in fields like Oxymorphone and Oxycodone. His Agonist research incorporates themes from Antagonist and Heteromer.
His Receptor course of study focuses on Structure–activity relationship and Cannabinoid, Drug tolerance and Cannabinoid receptor. Philip S. Portoghese combines subjects such as G protein-coupled receptor, Stereochemistry, In vivo and Receptor antagonist with his study of Opioid receptor. His Stereochemistry research incorporates elements of Opioid antagonist and Naltrexone.
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International Union of Pharmacology. XII. Classification of opioid receptors
BN Dhawan;F Cesselin;R Raghubir;T Reisine.
Pharmacological Reviews (1996)
Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist
Philip S Portoghese;M. Sultana;A. E. Takemori.
European Journal of Pharmacology (1988)
Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists
P.S. Portoghese;A.W. Lipkowski;A.E. Takemori.
Life Sciences (1987)
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
E E Abdelhamid;M Sultana;P S Portoghese;A E Takemori.
Journal of Pharmacology and Experimental Therapeutics (1991)
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
Stephen D. Mague;Andrea M. Pliakas;Mark S. Todtenkopf;Hilarie C. Tomasiewicz.
Journal of Pharmacology and Experimental Therapeutics (2003)
Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.
A E Takemori;B Y Ho;J S Naeseth;P S Portoghese.
Journal of Pharmacology and Experimental Therapeutics (1988)
Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
M. Sofuoglu;Philip S Portoghese;A. E. Takemori.
Journal of Pharmacology and Experimental Therapeutics (1991)
A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.
Philip S. Portoghese;Dennis L. Larson;Lawrence M. Sayre;David S. Fries.
Journal of Medicinal Chemistry (1980)
Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.
S. J. Ward;Philip S Portoghese;A. E. Takemori.
Journal of Pharmacology and Experimental Therapeutics (1982)
Design of peptidomimetic .delta. opioid receptor antagonists using the message-address concept
Philip S Portoghese;M. Sultana;A. E. Takemori.
Journal of Medicinal Chemistry (1990)
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