World's Best Scientists 2026 revealed!
Philip S. Portoghese

Philip S. Portoghese

D-Index & Metrics

Medicine

D-Index
86
Citations
25034
World Ranking
14219
National Ranking
7191

Chemistry

D-Index
86
Citations
25486
World Ranking
2549
National Ranking
891

Philip S. Portoghese publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where Philip S. Portoghese sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 447 publications — 85th percentile

85% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

Philip S. Portoghese D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Philip S. Portoghese sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 86 D-Index — 86th percentile

86% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2010 - Fellow of the American Chemical Society
  • 1986 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Philip S. Portoghese is affiliated with the University of Minnesota in the United States. Their research spans multiple interconnected fields, primarily focused on neuroscience, medicine, and biochemistry, genetics, and molecular biology.

The scientist's main fields of study include:

  • Neuroscience
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these disciplines, the subfields most frequently associated with their work are:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Physiology
  • Anesthesiology and Pain Medicine
  • Pharmacology

The topics covered by their publications reflect a concentrated interest in neuropharmacology and pain management, including:

  • Neuropeptides and Animal Physiology
  • Pain Mechanisms and Treatments
  • Pharmacological Receptor Mechanisms and Effects
  • Receptor Mechanisms and Signaling
  • Pain Management and Opioid Use
  • Neuroscience and Neuropharmacology Research
  • Plant-based Medicinal Research

Philip S. Portoghese's recent papers illustrate a focus on opioid receptor pharmacology and pain modulation. Notable publications include:

  • The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids (2020, Pain)
  • Opioid receptors in GtoPdb v.2023.1 (2023, IUPHAR/BPS Guide to Pharmacology CITE)
  • FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR-DOR Heteromer (2020, Biochemistry)
  • MMG22 Potently Blocks Hyperalgesia in Cisplatin-treated Mice (2023, Neuroscience)
  • Peripherally mediated opioid combination therapy in mouse and pig (2024, Journal of Pain)

Frequently collaborating with other researchers, some of their most common co-authors are:

  • Mary M. Lunzer
  • Eyup Akgün
  • Anna Borsodi
  • Michael R. Bruchas
  • Girolamo Calò

The venues where Philip S. Portoghese has most often published include:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • Neuroscience
  • Pain
  • Biochemistry
  • Journal of Pain

Throughout their career, Philip S. Portoghese has received recognition as a Fellow of the American Chemical Society in 2010 and a Fellow of the American Association for the Advancement of Science (AAAS) in 1986.

Best Publications

  • Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

    P.S. Portoghese;M. Sultana;A.E. Takemori

  • Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists

    P.S. Portoghese;A.W. Lipkowski;A.E. Takemori

  • Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.

    E E Abdelhamid;M Sultana;P S Portoghese;A E Takemori

  • Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats

    Stephen D. Mague;Andrea M. Pliakas;Mark S. Todtenkopf;Hilarie C. Tomasiewicz

  • Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.

    A E Takemori;B Y Ho;J S Naeseth;P S Portoghese

  • Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.

    M. Sofuoglu;Philip S Portoghese;A. E. Takemori

  • A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.

    Philip S. Portoghese;Dennis L. Larson;Lawrence M. Sayre;David S. Fries

  • A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

    Maria Waldhoer;Jamie Fong;Robert M. Jones;Mary M. Lunzer

  • Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.

    S J Ward;P S Portoghese;A E Takemori

  • A New Concept on the Mode of Interaction of Narcotic Analgesics with Receptors

    Philip S. Portoghese

  • Design of peptidomimetic .delta. opioid receptor antagonists using the message-address concept

    P. S. Portoghese;M. Sultana;A. E. Takemori

  • Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.

    Q. Jiang;A. E. Takemori;M. Sultana;P. S. Portoghese

  • Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists.

    Philip S Portoghese;M. Sultana;H. Nagase;A. E. Takemori

  • Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

    David J. Daniels;Natalie R. Lenard;Chris L. Etienne;Ping Yee Law

  • Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists

    Philip S. Portoghese

  • The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone.

    A.E. Takemori;Dennis L. Larson;P.S. Portoghese

  • Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.

    R.L Smith;T.B Adams;J Doull;V.J Feron

  • Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats

    Mark S. Todtenkopf;Jacqueline F. Marcus;Philip S. Portoghese;William A. Carlezon

  • Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures.

    Phillip K. Peterson;Burt M. Sharp;Genya Gekker;P. S. Portoghese

  • The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients.

    Timothy B. Adams;Samuel Monroe Cohen;John Doull;Victor J. Feron

  • From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes.

    Philip S. Portoghese

Frequent Co-Authors

Robert L. Smith
Robert L. Smith Imperial College London
Lawrence J. Marnett
Lawrence J. Marnett Vanderbilt University
Samuel Monroe Cohen
Samuel Monroe Cohen University of Nebraska Medical Center
David M. Ferguson
David M. Ferguson University of Minnesota
Frank Porreca
Frank Porreca University of Arizona
Ivonne M.C.M. Rietjens
Ivonne M.C.M. Rietjens Wageningen University & Research
Phillip K. Peterson
Phillip K. Peterson University of Minnesota
Henry I. Mosberg
Henry I. Mosberg University of Michigan–Ann Arbor
Shuxian Hu
Shuxian Hu University of Minnesota

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