World's Best Scientists 2026 revealed!
Philip S. Portoghese

Philip S. Portoghese

D-Index & Metrics

Chemistry

D-Index
86
Citations
25486
World Ranking
2549
National Ranking
892

Medicine

D-Index
86
Citations
25034
World Ranking
14219
National Ranking
7191

Research.com Recognitions

  • 2010 - Fellow of the American Chemical Society
  • 1986 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Philip S. Portoghese is affiliated with the University of Minnesota in the United States. Their research spans multiple interconnected fields, primarily focused on neuroscience, medicine, and biochemistry, genetics, and molecular biology.

The scientist's main fields of study include:

  • Neuroscience
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these disciplines, the subfields most frequently associated with their work are:

  • Cellular and Molecular Neuroscience
  • Molecular Biology
  • Physiology
  • Anesthesiology and Pain Medicine
  • Pharmacology

The topics covered by their publications reflect a concentrated interest in neuropharmacology and pain management, including:

  • Neuropeptides and Animal Physiology
  • Pain Mechanisms and Treatments
  • Pharmacological Receptor Mechanisms and Effects
  • Receptor Mechanisms and Signaling
  • Pain Management and Opioid Use
  • Neuroscience and Neuropharmacology Research
  • Plant-based Medicinal Research

Philip S. Portoghese's recent papers illustrate a focus on opioid receptor pharmacology and pain modulation. Notable publications include:

  • The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids (2020, Pain)
  • Opioid receptors in GtoPdb v.2023.1 (2023, IUPHAR/BPS Guide to Pharmacology CITE)
  • FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR-DOR Heteromer (2020, Biochemistry)
  • MMG22 Potently Blocks Hyperalgesia in Cisplatin-treated Mice (2023, Neuroscience)
  • Peripherally mediated opioid combination therapy in mouse and pig (2024, Journal of Pain)

Frequently collaborating with other researchers, some of their most common co-authors are:

  • Mary M. Lunzer
  • Eyup Akgün
  • Anna Borsodi
  • Michael R. Bruchas
  • Girolamo Calò

The venues where Philip S. Portoghese has most often published include:

  • IUPHAR/BPS Guide to Pharmacology CITE
  • Neuroscience
  • Pain
  • Biochemistry
  • Journal of Pain

Throughout their career, Philip S. Portoghese has received recognition as a Fellow of the American Chemical Society in 2010 and a Fellow of the American Association for the Advancement of Science (AAAS) in 1986.

Best Publications

  • Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

    P.S. Portoghese;M. Sultana;A.E. Takemori

  • Binaltorphimine and nor-binaltorphimine, potent and selective k-opioid receptor antagonists

    P.S. Portoghese;A.W. Lipkowski;A.E. Takemori

  • Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.

    E E Abdelhamid;M Sultana;P S Portoghese;A E Takemori

  • Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats

    Stephen D. Mague;Andrea M. Pliakas;Mark S. Todtenkopf;Hilarie C. Tomasiewicz

  • Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays.

    A E Takemori;B Y Ho;J S Naeseth;P S Portoghese

  • Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.

    M. Sofuoglu;Philip S Portoghese;A. E. Takemori

  • A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities.

    Philip S. Portoghese;Dennis L. Larson;Lawrence M. Sayre;David S. Fries

  • A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

    Maria Waldhoer;Jamie Fong;Robert M. Jones;Mary M. Lunzer

  • Pharmacological characterization in vivo of the novel opiate, beta-funaltrexamine.

    S J Ward;P S Portoghese;A E Takemori

  • A New Concept on the Mode of Interaction of Narcotic Analgesics with Receptors

    Philip S. Portoghese

  • Design of peptidomimetic .delta. opioid receptor antagonists using the message-address concept

    P. S. Portoghese;M. Sultana;A. E. Takemori

  • Differential antagonism of opioid delta antinociception by [D-Ala2,Leu5,Cys6]enkephalin and naltrindole 5'-isothiocyanate: evidence for delta receptor subtypes.

    Q. Jiang;A. E. Takemori;M. Sultana;P. S. Portoghese

  • Application of the message-address concept in the design of highly potent and selective non-peptide delta opioid receptor antagonists.

    Philip S Portoghese;M. Sultana;H. Nagase;A. E. Takemori

  • Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

    David J. Daniels;Natalie R. Lenard;Chris L. Etienne;Ping Yee Law

  • Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists

    Philip S. Portoghese

  • The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone.

    A.E. Takemori;Dennis L. Larson;P.S. Portoghese

  • Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.

    R.L Smith;T.B Adams;J Doull;V.J Feron

  • Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats

    Mark S. Todtenkopf;Jacqueline F. Marcus;Philip S. Portoghese;William A. Carlezon

  • Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures.

    Phillip K. Peterson;Burt M. Sharp;Genya Gekker;P. S. Portoghese

  • The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients.

    Timothy B. Adams;Samuel Monroe Cohen;John Doull;Victor J. Feron

  • From models to molecules: opioid receptor dimers, bivalent ligands, and selective opioid receptor probes.

    Philip S. Portoghese

Frequent Co-Authors

Robert L. Smith
Robert L. Smith Imperial College London
Lawrence J. Marnett
Lawrence J. Marnett Vanderbilt University
Samuel Monroe Cohen
Samuel Monroe Cohen University of Nebraska Medical Center
David M. Ferguson
David M. Ferguson University of Minnesota
Frank Porreca
Frank Porreca University of Arizona
Ivonne M.C.M. Rietjens
Ivonne M.C.M. Rietjens Wageningen University & Research
Phillip K. Peterson
Phillip K. Peterson University of Minnesota
Henry I. Mosberg
Henry I. Mosberg University of Michigan–Ann Arbor
Shuxian Hu
Shuxian Hu University of Minnesota

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