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Biology and Biochemistry

D-Index
51
Citations
13708
World Ranking
16977
National Ranking
716

Overview

Manuel S. Rodriguez is affiliated with the Centre national de la recherche scientifique (CNRS) in France. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a significant number of publications in medicine as well. Their work spans several subfields including molecular biology, oncology, epidemiology, cell biology, and hematology.

The main topics of their research encompass ubiquitin and proteasome pathways, autophagy in disease and therapy, peptidase inhibition and analysis, protein degradation and inhibitors, endoplasmic reticulum stress and disease, viral-associated cancers and disorders, and cancer-related gene regulation.

Their recent papers reflect diverse investigations within these areas, including:

  • Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation, 2021, Cell Reports
  • Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma, 2020, Advances in Experimental Medicine and Biology
  • Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy, 2020, Molecules
  • SUMOylation modulates the stability and function of PI3K-p110β, 2021, Cellular and Molecular Life Sciences
  • Breaking Bad Proteins-Discovery Approaches and the Road to Clinic for Degraders, 2024, Cells

The scientist collaborates frequently with other researchers. Notable frequent co-authors include Rosa Barrio, Grégoire Quinet, María Gonzalez-Santamarta, James D. Sutherland, and Rune Matthiesen.

Regarding publication venues, Manuel S. Rodriguez has contributed multiple works to:

  • Methods in Molecular Biology
  • Cell Reports
  • Cells
  • Seminars in Cell and Developmental Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

In addition to journal articles, Manuel S. Rodriguez has several book publications. Publishers include Springer Nature, Centre National de la Recherche Scientifique, and Springer Science+Business Media. The books published are:

  • Proteostasis and Disease, 2020, Springer Nature
  • Proteostasis and disease: from basic mechanisms to clinics, 2020, Centre National de la Recherche Scientifique
  • The Ubiquitin Code, 2022, Springer Science+Business Media

Best Publications

  • SUMO-1 Modification of IκBα Inhibits NF-κB Activation

    Joana M.P Desterro;Manuel S Rodriguez;Ronald T Hay

  • SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting

    Manuel S. Rodriguez;Catherine Dargemont;Catherine Dargemont;Ronald T. Hay

  • SUMO-1 modification activates the transcriptional response of p53

    Manuel S. Rodriguez;Joana M. P. Desterro;Sonia Lain;Carol A. Midgley

  • Human immunodeficiency virus infection modified the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis

    Basilio Soto;Armandó Sánchez-Quijano;Luis Rodrigo;Juan Angel del Olmo

  • Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm

    F. Arenzana-Seisdedos;P. Turpin;M. Rodriguez;D. Thomas

  • Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B

    F Arenzana-Seisdedos;J Thompson;M S Rodriguez;F Bachelerie

  • Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

    Manuel S Rodriguez;Joana M P Desterro;Sonia Lain;David P. Lane

  • Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

    Roland Hjerpe;Fabienne Aillet;Fernando Lopitz‐Otsoa;Valerie Lang

  • Identification of the Enzyme Required for Activation of the Small Ubiquitin-like Protein SUMO-1

    Joana M.P. Desterro;Manuel S. Rodriguez;Graham D. Kemp;Ronald T. Hay

  • Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivo.

    Marilynn Roff;Jill Thompson;Manuel S. Rodriguez;Jean-Marc Jacque

  • Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

    Manuel S. Rodriguez;Jill Thompson;Ronald T. Hay;Catherine Dargemont

  • A proteomic study of SUMO-2 target proteins.

    Alfred C.O. Vertegaal;Stephen C. Ogg;Ellis Jaffray;Manuel S. Rodriguez

  • E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation

    Laurent Le Cam;Laëtitia K. Linares;Conception Paul;Eric Julien

  • Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.

    Guillaume Bossis;Cécile E. Malnou;Rosa Farras;Elisabetta Andermarcher

  • Nuclear export of RNA

    Manuel S. Rodriguez;Catherine Dargemont;Françoise Stutz

  • Dependability of COTS microkernel-based systems

    J. Arlat;J.-C. Fabre;M. Rodriguez

  • Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: a double-blind RCT.

    Juan Carlos García-Pagán;Rosa Morillas;Rafael Bañares;Agustin Albillos

  • Detection of protein SUMOylation in vivo.

    Michael H Tatham;Manuel S Rodriguez;Dimitris P Xirodimas;Ronald T Hay

  • Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivo.

    Rodriguez Ms;Wright J;Thompson J;Thomas D

  • Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription

    Carole Gwizdek;Nahid Iglesias;Manuel S. Rodriguez;Batool Ossareh-Nazari

Frequent Co-Authors

Ronald T. Hay
Ronald T. Hay University of Dundee
Catherine Dargemont
Catherine Dargemont Université Paris Cité
Patrick England
Patrick England Institut Pasteur
Fernando Arenzana-Seisdedos
Fernando Arenzana-Seisdedos Chinese Academy of Sciences
Arkaitz Carracedo
Arkaitz Carracedo University of the Basque Country
Jean-Louis Virelizier
Jean-Louis Virelizier Institut Pasteur
Mariano Esteban
Mariano Esteban Spanish National Research Council
José M. Mato
José M. Mato CIC bioGUNE
Shelly C. Lu
Shelly C. Lu Cedars-Sinai Medical Center
Françoise Bachelerie
Françoise Bachelerie University of Paris-Saclay

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