2026 John Silke: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Molecular Biology	94	646	575	15	14	263	40475

Overview

John Silke is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their work spans multiple fields, primarily focusing on biochemistry, genetics, and molecular biology, with a significant contribution to medicine. Their subfields of study include molecular biology, immunology, oncology, cancer research, and epidemiology.

The main topics in John Silke's research concentrate on cell death mechanisms and regulation, interferon and immune responses, ubiquitin and proteasome pathways, the inflammasome and immune disorders, NF-κB signaling pathways, PARP inhibition in cancer therapy, and immunotherapy and immune responses.

Noteworthy recent publications include:

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis (2020, Nature Communications)
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity (2024, Nature reviews. Cancer)
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease (2020, Nature Reviews Rheumatology)
Future Therapeutic Directions for Smac-Mimetics (2020, Cells)
An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling (2020, F1000Research)

John Silke frequently collaborates with several researchers, including:

James M. Murphy
Holly Anderton
Natasha Silke
Joanne M. Hildebrand
Lorraine A. O'Reilly

Their research is regularly published in venues such as Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell Death and Differentiation, and Cell Death and Disease.

Best Publications

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

6452
Citations
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Anne M Verhagen;Paul G Ekert;Paul G Ekert;Miha Pakusch;John Silke

3288
Citations
IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

James E. Vince;W. Wei-Lynn Wong;Nufail Khan;Rebecca Feltham

1271
Citations
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Lars. Zender;Mona S. Spector;Wen. Xue;Peer. Flemming

1243
Citations
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet

1187
Citations
Linear ubiquitination prevents inflammation and regulates immune signalling

Bjã¶rn Gerlach;Stefanie M. Cordier;Anna C. Schmukle;Christoph H. Emmerich;Christoph H. Emmerich

1028
Citations
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

Tobias L. Haas;Christoph H. Emmerich;Christoph H. Emmerich;Bjã¶rn Gerlach;Bjã¶rn Gerlach;Anna C. Schmukle

836
Citations
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.

Anne M Verhagen;John Silke;Paul G Ekert;Paul G Ekert;Miha Pakusch

788
Citations
IAPs, RINGs and ubiquitylation

David L. Vaux;John Silke

779
Citations
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

Vanessa S. Marsden;Liam O'Connor;Liam O'Connor;Lorraine A. O'Reilly;John Silke

722
Citations
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

Kate E. Lawlor;Nufail Khan;Alison Mildenhall;Motti Gerlic

660
Citations
RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

James A Rickard;James A Rickard;Joanne A O'Donnell;Joanne A O'Donnell;Joseph M Evans;Joseph M Evans;Najoua Lalaoui;Najoua Lalaoui

634
Citations
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

James E. Vince;W. Wei Lynn Wong;W. Wei Lynn Wong;Ian Gentle;Kate E. Lawlor;Kate E. Lawlor

561
Citations
XIAP discriminates between type I and type II FAS-induced apoptosis

Philipp. Jost;Stephanie. Grabow;Stephanie. Grabow;Daniel. Gray;Mark D. McKenzie;Mark D. McKenzie

555
Citations
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young

553
Citations
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

V Sagulenko;S J Thygesen;D P Sester;A Idris

515
Citations
The diverse role of RIP kinases in necroptosis and inflammation

John Silke;James A Rickard;Motti Gerlic

509
Citations
The Drosophila caspase DRONC is regulated by DIAP1.

Pascal Meier;John Silke;Sally J. Leevers;Gerard I. Evan;Gerard I. Evan;Gerard I. Evan

411
Citations
The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

Rune Busk Damgaard;Ueli Nachbur;Ueli Nachbur;Ueli Nachbur;Monica Yabal;Wendy Wei-Lynn Wong;Wendy Wei-Lynn Wong

396
Citations
The diverse role of RIP kinases in necroptosis and inflammation (vol 16, pg 930, 2016)

John Silke;James A Rickard;Motti Gerlic

0
Citations

Frequent Co-Authors

David L. Vaux Walter and Eliza Hall Institute of Medical Research

James M. Murphy Walter and Eliza Hall Institute of Medical Research

Paul G Ekert University of New South Wales

James E. Vince Walter and Eliza Hall Institute of Medical Research

Andreas Strasser Walter and Eliza Hall Institute of Medical Research

Warren S. Alexander Walter and Eliza Hall Institute of Medical Research

Andrew I. Webb Walter and Eliza Hall Institute of Medical Research

Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research

Kate E. Lawlor Hudson Institute of Medical Research

Marc Pellegrini Walter and Eliza Hall Institute of Medical Research

External Links

Personal website of John Silke

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