The scientist’s investigation covers issues in Cell biology, Programmed cell death, Inhibitor of apoptosis, XIAP and Apoptosis. His Cell biology research is multidisciplinary, incorporating elements of NFKB1 and Ubiquitin, Ubiquitin ligase. His studies in Programmed cell death integrate themes in fields like Tumor necrosis factor alpha and Inflammasome.
His Inhibitor of apoptosis study incorporates themes from Gene and Locus. His XIAP research is multidisciplinary, incorporating perspectives in Cancer research, Baculoviral IAP repeat-containing protein 3 and XIAP Deficiency. A large part of his Necroptosis studies is devoted to RIPK1.
John Silke mainly focuses on Cell biology, Programmed cell death, Cancer research, Necroptosis and Inhibitor of apoptosis. His work carried out in the field of Cell biology brings together such families of science as Caspase and Ubiquitin. Programmed cell death is a subfield of Apoptosis that John Silke investigates.
His work in Cancer research tackles topics such as Tumor necrosis factor alpha which are related to areas like NFKB1 and Cytokine. His Necroptosis study integrates concerns from other disciplines, such as Pyroptosis and Protein kinase A. John Silke usually deals with Inhibitor of apoptosis and limits it to topics linked to XIAP and XIAP Deficiency, Baculoviral IAP repeat-containing protein 3, Molecular biology, RIPK2 and Proinflammatory cytokine.
His main research concerns Programmed cell death, Cell biology, Necroptosis, Cancer research and Inhibitor of apoptosis. His Programmed cell death research is under the purview of Apoptosis. His biological study spans a wide range of topics, including XIAP and Ubiquitin, Ubiquitin ligase.
His Necroptosis research includes themes of Inflammation, Pyroptosis, Phosphorylation and Effector. The concepts of his Cancer research study are interwoven with issues in Tumor necrosis factor alpha, Missense mutation, Carcinogenesis and Immunotherapy. His research integrates issues of Caspase, Chimeric antigen receptor, Cell growth and In vivo in his study of Inhibitor of apoptosis.
John Silke mainly investigates Necroptosis, Cell biology, Programmed cell death, RIPK1 and Kinase activity. The study incorporates disciplines such as Inhibitor of apoptosis, Bcl-xL, XIAP and Caspase 7 in addition to Cell biology. His research on Programmed cell death concerns the broader Apoptosis.
His Apoptosis study combines topics in areas such as Receptor and Neuroscience. His RIPK1 research incorporates elements of Caspase, Caspase 8 and Signal transduction. His Caspase 8 research is multidisciplinary, incorporating elements of Inflammation, Cancer research and Tumor necrosis factor alpha.
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Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
Anne M Verhagen;Paul G Ekert;Paul G Ekert;Miha Pakusch;John Silke.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams.
Cell Death & Differentiation (2018)
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
Lars. Zender;Mona S. Spector;Wen. Xue;Peer. Flemming.
IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis
James E. Vince;W. Wei-Lynn Wong;Nufail Khan;Rebecca Feltham.
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet.
Linear ubiquitination prevents inflammation and regulates immune signalling
Bjã¶rn Gerlach;Stefanie M. Cordier;Anna C. Schmukle;Christoph H. Emmerich;Christoph H. Emmerich.
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
Anne M Verhagen;John Silke;Paul G Ekert;Paul G Ekert;Miha Pakusch.
Journal of Biological Chemistry (2002)
IAPs, RINGs and ubiquitylation.
David L. Vaux;John Silke.
Nature Reviews Molecular Cell Biology (2005)
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
Tobias L. Haas;Christoph H. Emmerich;Christoph H. Emmerich;Bjã¶rn Gerlach;Bjã¶rn Gerlach;Anna C. Schmukle.
Molecular Cell (2009)
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
Vanessa S. Marsden;Liam O'Connor;Liam O'Connor;Lorraine A. O'Reilly;John Silke.
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