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D-Index & Metrics

Molecular Biology

D-Index
94
Citations
40475
World Ranking
646
National Ranking
15

John Silke publication distribution in Molecular Biology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Molecular Biology in 2026. The highlighted bar marks where John Silke sits on this spectrum.

47–56 publications: 7 scientists 57–66 publications: 17 scientists 67–76 publications: 65 scientists 77–86 publications: 90 scientists 87–96 publications: 125 scientists 97–106 publications: 131 scientists 107–116 publications: 162 scientists 117–126 publications: 177 scientists 127–136 publications: 158 scientists 137–146 publications: 158 scientists 147–156 publications: 146 scientists 157–166 publications: 159 scientists 167–176 publications: 131 scientists 177–186 publications: 110 scientists 187–196 publications: 112 scientists 197–206 publications: 100 scientists 207–216 publications: 89 scientists 217–226 publications: 98 scientists 227–236 publications: 74 scientists 237–246 publications: 72 scientists 247–256 publications: 63 scientists 257–266 publications: 53 scientists 267–276 publications: 54 scientists 277–286 publications: 49 scientists 287–296 publications: 52 scientists 297–306 publications: 43 scientists 307–316 publications: 46 scientists 317–326 publications: 41 scientists 327–336 publications: 42 scientists 337–346 publications: 31 scientists 347–356 publications: 28 scientists 357–366 publications: 29 scientists 367–376 publications: 26 scientists 377–386 publications: 24 scientists 387–396 publications: 24 scientists 397–406 publications: 14 scientists 407–416 publications: 13 scientists 417–426 publications: 20 scientists 427–436 publications: 12 scientists 437–446 publications: 20 scientists 447–456 publications: 11 scientists 457–466 publications: 10 scientists 467–476 publications: 14 scientists 477–486 publications: 14 scientists 487–496 publications: 10 scientists 497–506 publications: 13 scientists 507–516 publications: 13 scientists 517–526 publications: 2 scientists 527–536 publications: 4 scientists 537–546 publications: 6 scientists 547–556 publications: 8 scientists 557–563 publications: 6 scientists 564+ publications: 100 scientists
47 publications 564+

This scientist: 263 publications — 74th percentile

74% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 564 publications or more.

John Silke D-index placement in Molecular Biology in 2026

The chart shows the D-index (discipline H-index) distribution of Molecular Biology scientists ranked by Research.com in 2026. The highlighted bar marks where John Silke sits on this spectrum.

40–41 D-Index: 36 scientists 42–43 D-Index: 101 scientists 44–45 D-Index: 115 scientists 46–47 D-Index: 121 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 130 scientists 52–53 D-Index: 106 scientists 54–55 D-Index: 116 scientists 56–57 D-Index: 113 scientists 58–59 D-Index: 129 scientists 60–61 D-Index: 120 scientists 62–63 D-Index: 105 scientists 64–65 D-Index: 131 scientists 66–67 D-Index: 95 scientists 68–69 D-Index: 97 scientists 70–71 D-Index: 106 scientists 72–73 D-Index: 83 scientists 74–75 D-Index: 89 scientists 76–77 D-Index: 77 scientists 78–79 D-Index: 70 scientists 80–81 D-Index: 73 scientists 82–83 D-Index: 60 scientists 84–85 D-Index: 48 scientists 86–87 D-Index: 45 scientists 88–89 D-Index: 50 scientists 90–91 D-Index: 31 scientists 92–93 D-Index: 51 scientists 94–95 D-Index: 43 scientists 96–97 D-Index: 38 scientists 98–99 D-Index: 39 scientists 100–101 D-Index: 41 scientists 102–103 D-Index: 29 scientists 104–105 D-Index: 33 scientists 106–107 D-Index: 35 scientists 108–109 D-Index: 20 scientists 110–111 D-Index: 38 scientists 112–113 D-Index: 19 scientists 114–115 D-Index: 28 scientists 116–117 D-Index: 13 scientists 118–119 D-Index: 23 scientists 120–121 D-Index: 16 scientists 122–123 D-Index: 15 scientists 124–125 D-Index: 11 scientists 126–127 D-Index: 21 scientists 128–129 D-Index: 7 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 14 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 9 scientists 138–139 D-Index: 8 scientists 140–141 D-Index: 16 scientists 142–143 D-Index: 7 scientists 144 D-Index: 7 scientists 145+ D-Index: 100 scientists
40 D-Index 145+

This scientist: 94 D-Index — 79th percentile

79% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 145 D-Index or more.

Overview

John Silke is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their work spans multiple fields, primarily focusing on biochemistry, genetics, and molecular biology, with a significant contribution to medicine. Their subfields of study include molecular biology, immunology, oncology, cancer research, and epidemiology.

The main topics in John Silke's research concentrate on cell death mechanisms and regulation, interferon and immune responses, ubiquitin and proteasome pathways, the inflammasome and immune disorders, NF-κB signaling pathways, PARP inhibition in cancer therapy, and immunotherapy and immune responses.

Noteworthy recent publications include:

  • MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis (2020, Nature Communications)
  • Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity (2024, Nature reviews. Cancer)
  • Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease (2020, Nature Reviews Rheumatology)
  • Future Therapeutic Directions for Smac-Mimetics (2020, Cells)
  • An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling (2020, F1000Research)

John Silke frequently collaborates with several researchers, including:

  • James M. Murphy
  • Holly Anderton
  • Natasha Silke
  • Joanne M. Hildebrand
  • Lorraine A. O'Reilly

Their research is regularly published in venues such as Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell Death and Differentiation, and Cell Death and Disease.

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

    Anne M Verhagen;Paul G Ekert;Paul G Ekert;Miha Pakusch;John Silke

  • IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

    James E. Vince;W. Wei-Lynn Wong;Nufail Khan;Rebecca Feltham

  • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

    Lars. Zender;Mona S. Spector;Wen. Xue;Peer. Flemming

  • The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

    James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet

  • Linear ubiquitination prevents inflammation and regulates immune signalling

    Bjã¶rn Gerlach;Stefanie M. Cordier;Anna C. Schmukle;Christoph H. Emmerich;Christoph H. Emmerich

  • Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

    Tobias L. Haas;Christoph H. Emmerich;Christoph H. Emmerich;Bjã¶rn Gerlach;Bjã¶rn Gerlach;Anna C. Schmukle

  • HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.

    Anne M Verhagen;John Silke;Paul G Ekert;Paul G Ekert;Miha Pakusch

  • IAPs, RINGs and ubiquitylation

    David L. Vaux;John Silke

  • Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

    Vanessa S. Marsden;Liam O'Connor;Liam O'Connor;Lorraine A. O'Reilly;John Silke

  • RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

    Kate E. Lawlor;Nufail Khan;Alison Mildenhall;Motti Gerlic

  • RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

    James A Rickard;James A Rickard;Joanne A O'Donnell;Joanne A O'Donnell;Joseph M Evans;Joseph M Evans;Najoua Lalaoui;Najoua Lalaoui

  • Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

    James E. Vince;W. Wei Lynn Wong;W. Wei Lynn Wong;Ian Gentle;Kate E. Lawlor;Kate E. Lawlor

  • XIAP discriminates between type I and type II FAS-induced apoptosis

    Philipp. Jost;Stephanie. Grabow;Stephanie. Grabow;Daniel. Gray;Mark D. McKenzie;Mark D. McKenzie

  • Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

    Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young

  • AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

    V Sagulenko;S J Thygesen;D P Sester;A Idris

  • The diverse role of RIP kinases in necroptosis and inflammation

    John Silke;James A Rickard;Motti Gerlic

  • The Drosophila caspase DRONC is regulated by DIAP1.

    Pascal Meier;John Silke;Sally J. Leevers;Gerard I. Evan;Gerard I. Evan;Gerard I. Evan

  • The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

    Rune Busk Damgaard;Ueli Nachbur;Ueli Nachbur;Ueli Nachbur;Monica Yabal;Wendy Wei-Lynn Wong;Wendy Wei-Lynn Wong

  • The diverse role of RIP kinases in necroptosis and inflammation (vol 16, pg 930, 2016)

    John Silke;James A Rickard;Motti Gerlic

Frequent Co-Authors

David L. Vaux
David L. Vaux Walter and Eliza Hall Institute of Medical Research
James M. Murphy
James M. Murphy Walter and Eliza Hall Institute of Medical Research
Paul G Ekert
Paul G Ekert University of New South Wales
James E. Vince
James E. Vince Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Warren S. Alexander
Warren S. Alexander Walter and Eliza Hall Institute of Medical Research
Andrew I. Webb
Andrew I. Webb Walter and Eliza Hall Institute of Medical Research
Peter E. Czabotar
Peter E. Czabotar Walter and Eliza Hall Institute of Medical Research
Kate E. Lawlor
Kate E. Lawlor Hudson Institute of Medical Research
Marc Pellegrini
Marc Pellegrini Walter and Eliza Hall Institute of Medical Research

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