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Robert G. Korneluk

Robert G. Korneluk

D-Index & Metrics

Genetics

D-Index
74
Citations
28256
World Ranking
1941
National Ranking
67

Research.com Recognitions

  • 1998 - Fellow of the Royal Society of Canada Academy of Science

Overview

Robert G. Korneluk is affiliated with the University of Ottawa in Canada. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology, with a focus on molecular biology, immunology, virology, and oncology.

Korneluk's work encompasses several main research topics, including RNA interference and gene delivery, cell death mechanisms and regulation, HIV research and treatment, immune cells in cancer, CAR-T cell therapy research, CRISPR and genetic engineering, and immune cell function and interaction.

The scientist has contributed to several recent publications, including:

  • Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages, 2021, Scientific Reports
  • LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling, 2023, Frontiers in Immunology
  • "Smac"ing the Life out of XIAP, 2020, The FASEB Journal
  • The Effects of XIAP on Alzheimer's Disease, 2020, The FASEB Journal
  • Author Correction: Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages, 2021, Scientific Reports

Frequent co-authors collaborating with Korneluk include Ramon Edwin Caballero, Simon Xin Min Dong, Niranjala Gajanayaka, Hamza Ali, and Edana Cassol.

Korneluk's work has been published primarily in the following venues:

  • Scientific Reports
  • The FASEB Journal
  • Frontiers in Immunology
  • Neuro-Oncology Advances

In recognition of their contributions to science, Korneluk was awarded the Fellow of the Royal Society of Canada in 1998 by the Academy of Science.

Best Publications

  • NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

    Cun Yu Wang;Marty W. Mayo;Robert G. Korneluk;David V. Goeddel

  • The inhibitors of apoptosis (IAPs) and their emerging role in cancer.

    Eric C LaCasse;Stephen Baird;Stephen Baird;Robert G Korneluk;Robert G Korneluk;Alex E MacKenzie;Alex E MacKenzie

  • Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

    Liston P;Roy N;Tamai K;Lefebvre C;Lefebvre C

  • The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

    Natalie Roy;Natalie Roy;Mani S. Mahadevan;Michael McLean;Michael McLean;Gary Shutter

  • Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK

    Brian J Zarnegar;Yaya Wang;Douglas J Mahoney;Paul W Dempsey

  • The inhibitors of apoptosis (IAPs) as cancer targets.

    Allison M. Hunter;Eric C. LaCasse;Robert G. Korneluk;Robert G. Korneluk

  • IAP-targeted therapies for cancer

    E C LaCasse;E C LaCasse;D J Mahoney;D J Mahoney;H H Cheung;H H Cheung;S Plenchette;S Plenchette

  • Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia

    D H MacLennan;C Duff;F Zorzato;J Fujii

  • Cloning of the essential myotonic dystrophy region and mapping of the putative defect

    Aslanidis C;Jansen G;Amemiya C;Shutler G

  • Both cIAP1 and cIAP2 regulate TNFα-mediated NF-κB activation

    D. J. Mahoney;H. H. Cheung;R. Lejmi Mrad;S. Plenchette

  • Identification of XAF1 as an antagonist of XIAP anti-Caspase activity.

    Peter Liston;Wai Gin Fong;N. Lynn Kelly;Shingo Toji

  • The inhibitors of apoptosis: there is more to life than Bcl2.

    Peter Liston;Wai Gin Fong;Robert G Korneluk;Robert G Korneluk

  • XIAP: apoptotic brake and promising therapeutic target.

    Martin Holcik;Hilary Gibson;Robert G. Korneluk

  • Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells.

    Jennifer Tran;Janusz Rak;Capucine Sheehan;Samuel D. Saibil

  • Correlation between CTG trinucleotide repeat length and frequency of severe congenital myotonic dystrophy

    Catherine Tsilfidis;Alex E. MacKenzie;Alex E. MacKenzie;Gabrielle Mettler;Juana Barceló

  • Searching for IRES.

    Stephen D. Baird;Marcel Turcotte;Robert G. Korneluk;Martin Holcik

  • XIAP, the guardian angel

    Martin Holcik;Robert G. Korneluk

  • A new internal-ribosome-entry-site motif potentiates XIAP- mediated cytoprotection

    Martin Holcik;Charles Lefebvre;Chiaoli Yeh;Terry Chow

  • Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

    Mathieu J.M. Bertrand;Karine Doiron;Katherine Labbé;Robert G. Korneluk

  • Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.

    Martin Holcik;Chiaoli Yeh;Robert G Korneluk;Robert G Korneluk;Terry Chow

Frequent Co-Authors

Alex MacKenzie
Alex MacKenzie Children's Hospital of Eastern Ontario
Martin Holcik
Martin Holcik Carleton University
Benjamin K. Tsang
Benjamin K. Tsang Ottawa Hospital Research Institute
William W. Hauswirth
William W. Hauswirth University of Florida
Timothy W. McKeithan
Timothy W. McKeithan City Of Hope National Medical Center
David H. MacLennan
David H. MacLennan University of Toronto
Subash Sad
Subash Sad University of Ottawa
Guy A. Rouleau
Guy A. Rouleau Montreal Neurological Institute and Hospital
Pieter J. de Jong
Pieter J. de Jong UCSF Benioff Children's Hospital
Catharina Larsson
Catharina Larsson Karolinska University Hospital

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