Alex MacKenzie focuses on Genetics, NAIP, Inhibitor of apoptosis, Cell biology and Baculoviral IAP repeat-containing protein 3. His work on Myotonin-protein kinase, Ctg repeat and Myotonic dystrophy as part of general Genetics research is frequently linked to Population, thereby connecting diverse disciplines of science. His NAIP research incorporates elements of NLR Proteins, Hippocampus and In vivo.
While the research belongs to areas of Inhibitor of apoptosis, he spends his time largely on the problem of XIAP, intersecting his research to questions surrounding Inhibitor of apoptosis domain. The Cell biology study combines topics in areas such as Molecular biology, Caspase 7 and Programmed cell death. Alex MacKenzie has researched Apoptosis in several fields, including Cellular differentiation, Immunology and Protein family.
His main research concerns Genetics, NAIP, Spinal muscular atrophy, Gene and Molecular biology. His biological study spans a wide range of topics, including Gene expression, Inhibitor of apoptosis, Apoptosis, Cell biology and Candidate gene. His Inhibitor of apoptosis research focuses on Baculoviral IAP repeat-containing protein 3 in particular.
His work carried out in the field of Spinal muscular atrophy brings together such families of science as Mutation, Neuromuscular disease and Motor neuron. His Gene research integrates issues from Computational biology and Rare disease. His Molecular biology research includes themes of Messenger RNA and DNA.
Alex MacKenzie spends much of his time researching Severe acute respiratory syndrome coronavirus 2, Wastewater, Rare disease, Spinal muscular atrophy and Neuromuscular disease. He undertakes interdisciplinary study in the fields of Spinal muscular atrophy and Nusinersen through his research. His study in Neuromuscular disease is interdisciplinary in nature, drawing from both Clinical trial, Duchenne muscular dystrophy, Myotonic dystrophy, Pediatrics and Weakness.
His study looks at the intersection of Duchenne muscular dystrophy and topics like Cancer research with Downregulation and upregulation. His PI3K/AKT/mTOR pathway study is concerned with the larger field of Cell biology. Alex MacKenzie undertakes multidisciplinary studies into Cell biology and Alveolar rhabdomyosarcoma in his work.
Wastewater, Gene, Computational biology, Severe acute respiratory syndrome coronavirus 2 and 16S ribosomal RNA are his primary areas of study. Wastewater is integrated with Emergency medicine, Clinical tests and Public health in his study. His studies deal with areas such as Drug discovery, Drug and Rare disease as well as Gene.
His work carried out in the field of Computational biology brings together such families of science as genomic DNA, Genetic disorder, DNA extraction, Danio and Neurogenetics. The various areas that he examines in his 16S ribosomal RNA study include RNA, 18S ribosomal RNA, Biotechnology and Incidence. His RNA study combines topics in areas such as Biomarker and Feces.
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The inhibitors of apoptosis (IAPs) and their emerging role in cancer.
Eric C LaCasse;Stephen Baird;Stephen Baird;Robert G Korneluk;Robert G Korneluk;Alex E MacKenzie;Alex E MacKenzie.
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes
Liston P;Roy N;Tamai K;Lefebvre C;Lefebvre C.
The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy
Natalie Roy;Natalie Roy;Mani S. Mahadevan;Michael McLean;Michael McLean;Gary Shutter.
Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome
Giuseppe Pilia;Rhiannon M. Hughes-Benzie;Alex MacKenzie;Primo Baybayan.
Nature Genetics (1996)
The NLR gene family: a standard nomenclature
Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin.
Rare-disease genetics in the era of next-generation sequencing: discovery to translation
Kym M. Boycott;Megan R. Vanstone;Dennis E. Bulman;Alex E. MacKenzie.
Nature Reviews Genetics (2013)
Correlation between CTG trinucleotide repeat length and frequency of severe congenital myotonic dystrophy
Catherine Tsilfidis;Alex E. MacKenzie;Alex E. MacKenzie;Gabrielle Mettler;Juana Barceló.
Nature Genetics (1992)
Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus
D.G. Xu;S.J. Crocker;J.-P. Doucet;M. St-Jean.
Nature Medicine (1997)
The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7
Johannes K. X. Maier;Zahia Lahoua;Nathalie H. Gendron;Raouf Fetni.
The Journal of Neuroscience (2002)
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage
Nicole Arbour;Jacqueline L Vanderluit;J Nicole Le Grand;Arezu Jahani-Asl.
The Journal of Neuroscience (2008)
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