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Biology and Biochemistry

D-Index
53
Citations
14494
World Ranking
15965
National Ranking
555

Overview

Alex MacKenzie is affiliated with the Children's Hospital of Eastern Ontario in Canada. Their research activity spans multiple fields within medicine and biological sciences, with notable work in infectious diseases and molecular biology. The primary focus of their research is related to SARS-CoV-2 detection and COVID-19, along with contributions to neurogenetic and muscular disorders research.

MacKenzie's work includes several published papers on wastewater surveillance as a method to monitor viral RNA, particularly for SARS-CoV-2. Key papers include:

  • Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence (2020, Water Research)
  • Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 hours before COVID-19 clinical tests and 96 hours before hospitalizations (2021, The Science of The Total Environment)
  • Municipal and neighbourhood level wastewater surveillance and subtyping of an influenza virus outbreak (2022, Scientific Reports)
  • COVID-19 wastewater surveillance in rural communities: Comparison of lagoon and pumping station samples (2021, The Science of The Total Environment)
  • A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer (2022, Cancers)

MacKenzie's frequent coauthors are:

  • Élisabeth Mercier
  • Robert Delatolla
  • Patrick M. D'Aoust
  • Tyson E. Graber
  • Nada Hegazy

The most common publication venues for MacKenzie's work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Science of The Total Environment
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • Neurology
  • Water Research

The main fields of study reflected in MacKenzie's body of work are:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

MacKenzie's research focuses on several subfields, including:

  • Infectious Diseases
  • Molecular Biology
  • Genetics
  • Epidemiology
  • Biomedical Engineering

Topics frequently addressed in their work involve:

  • SARS-CoV-2 detection and testing
  • SARS-CoV-2 and COVID-19 Research
  • Neurogenetic and Muscular Disorders Research
  • Muscle Physiology and Disorders
  • COVID-19 Clinical Research Studies
  • Biosensors and Analytical Detection
  • Respiratory viral infections research

In addition to journal articles, MacKenzie has contributed to book publications, including a title published by Edward Elgar Publishing:

  • The European Union as a Global Counter-Terrorism Actor (2022)

Best Publications

  • The inhibitors of apoptosis (IAPs) and their emerging role in cancer.

    Eric C LaCasse;Stephen Baird;Stephen Baird;Robert G Korneluk;Robert G Korneluk;Alex E MacKenzie;Alex E MacKenzie

  • Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

    Liston P;Roy N;Tamai K;Lefebvre C;Lefebvre C

  • The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

    Natalie Roy;Natalie Roy;Mani S. Mahadevan;Michael McLean;Michael McLean;Gary Shutter

  • The NLR gene family: a standard nomenclature

    Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin

  • Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

    Giuseppe Pilia;Rhiannon M. Hughes-Benzie;Alex MacKenzie;Primo Baybayan

  • Rare-disease genetics in the era of next-generation sequencing: discovery to translation

    Kym M. Boycott;Megan R. Vanstone;Dennis E. Bulman;Alex E. MacKenzie

  • Correlation between CTG trinucleotide repeat length and frequency of severe congenital myotonic dystrophy

    Catherine Tsilfidis;Alex E. MacKenzie;Alex E. MacKenzie;Gabrielle Mettler;Juana Barceló

  • Quantitative analysis of SARS-CoV-2 RNA from wastewater solids in communities with low COVID-19 incidence and prevalence.

    Patrick M. D'Aoust;Elisabeth Mercier;Danika Montpetit;Jian Jun Jia

  • Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

    D.G. Xu;S.J. Crocker;J.-P. Doucet;M. St-Jean

  • The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7

    Johannes K. X. Maier;Zahia Lahoua;Nathalie H. Gendron;Raouf Fetni

  • Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

    Nicole Arbour;Jacqueline L Vanderluit;J Nicole Le Grand;Arezu Jahani-Asl

  • Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 h before COVID-19 clinical tests and 96 h before hospitalizations.

    Patrick M. D'Aoust;Tyson E. Graber;Elisabeth Mercier;Danika Montpetit

  • Adenovirus‐Mediated Gene Transfer of Inhibitors of Apoptosis Proteins Delays Apoptosis in Cerebellar Granule Neurons

    M. Simons;S. Beinroth;M. Gleichmann;P. Liston

  • Watson syndrome: is it a subtype of type 1 neurofibromatosis?

    J E Allanson;M Upadhyaya;G H Watson;M Partington

  • Simpson-Golabi-Behmel syndrome: genotype/phenotype analysis of 18 affected males from 7 unrelated families.

    R.M. Hughes-Benzie;G. Pilia;J.Y. Xuan;A.G.W. Hunter

  • Expression of inhibitor of apoptosis proteins (IAPs) in rat granulosa cells during ovarian follicular development and atresia.

    Julang Li;Jong-Min Kim;Peter Liston;Ming Li

  • DNM1L- related mitochondrial fission defect presenting as refractory epilepsy

    Jason R Vanstone;Amanda M Smith;Skye McBride;Turaya Naas

  • p38 Mitogen-Activated Protein Kinase Stabilizes SMN mRNA Through RNA Binding Protein HuR

    Faraz Farooq;Sylvia Balabanian;Xuejun Liu;Martin Holcik

  • NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease.

    Stephen J. Crocker;Nichola Wigle;Peter Liston;Charlie S. Thompson

  • Catching a resurgence: Increase in SARS-CoV-2 viral RNA identified in wastewater 48 hours before COVID-19 clinical tests and 96 hours before hospitalizations

    Patrick M. D’Aoust;Tyson E. Graber;Elisabeth Mercier;Danika Montpetit

Frequent Co-Authors

Robert G. Korneluk
Robert G. Korneluk University of Ottawa
Kym M. Boycott
Kym M. Boycott Children's Hospital of Eastern Ontario
Martin Holcik
Martin Holcik Carleton University
Benjamin K. Tsang
Benjamin K. Tsang Ottawa Hospital Research Institute
Daniel Figeys
Daniel Figeys University of Ottawa
David A. Dyment
David A. Dyment University of Ottawa
Mark R. Servos
Mark R. Servos University of Waterloo
David R. Mack
David R. Mack University of Ottawa
Timothy W. McKeithan
Timothy W. McKeithan City Of Hope National Medical Center
Dennis E. Bulman
Dennis E. Bulman Children's Hospital of Eastern Ontario

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