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Genetics

D-Index
50
Citations
9913
World Ranking
3928
National Ranking
1692

Overview

Timothy W. McKeithan is affiliated with the City Of Hope National Medical Center in the United States and has a research focus primarily within the field of Medicine. Their work encompasses several subfields, including Pathology and Forensic Medicine, Oncology, Immunology, Molecular Biology, and Cancer Research.

The main topics of their research include:

  • Lymphoma Diagnosis and Treatment
  • Viral-associated cancers and disorders
  • Immune Cell Function and Interaction
  • T-cell and Retrovirus Studies
  • Cancer-related molecular mechanisms research
  • CAR-T cell therapy research
  • Chronic Lymphocytic Leukemia Research

McKeithan has contributed to several published papers over the years. Notable recent publications include:

  • Genomic profiling identifies distinct genetic subtypes in extra-nodal natural killer/T-cell lymphoma, 2022, Leukemia
  • Genome-Wide miRNA Expression Profiling of Molecular Subgroups of Peripheral T-cell Lymphoma, 2021, Clinical Cancer Research
  • Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1, 2020, Haematologica
  • High-grade B-cell lymphoma not otherwise specified, with diffuse large B-cell lymphoma gene expression signatures: Genomic analysis and potential therapeutics, 2024, American Journal of Hematology
  • MiR-17∼92 is involved in NF-κB activation via targeting the ubiquitin-editing proteins to mediate RIP1 complex polyubiquitinations in ABC-DLBCL, 2024, Clinical Immunology

Frequent co-authors collaborating with McKeithan include:

  • Javeed Iqbal
  • Wing C. Chan
  • Alyssa Bouska
  • Xuxiang Liu
  • Yuping Li

McKeithan's research findings have been published in a range of scientific journals with multiple contributions to the following venues:

  • Leukemia
  • Clinical Cancer Research
  • American Journal of Hematology
  • Haematologica
  • Clinical Immunology

Best Publications

  • Kinetic proofreading in T-cell receptor signal transduction.

    Timothy W. McKeithan

  • The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control

    Hitoshi Ohno;Glenn Takimoto;Timothy W. McKeithan

  • Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells

    Can Küçük;Bei Jiang;Xiaozhou Hu;Wenyan Zhang

  • Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.

    B W Baron;G Nucifora;N McCabe;rd R Espinosa

  • The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding

    E N Hatada;A Nieters;F G Wulczyn;M Naumann

  • Replication of a Common Fragile Site, FRA3B, Occurs Late in S Phase and is Delayed Further Upon Induction: Implications for the Mechanism of Fragile Site Induction

    Michelle M. Le Beau;Feyruz V. Rassool;Mary E. Neilly;Rafael Espinosa

  • Morphology in Ki-1 (CD30)-Positive Non Hodgkin's Lymphoma Is Correlated with Clinical Features and the Presence of a Unique Chromosomal Abnormality, t(2;5)(p23;q35)

    M. A. Bitter;W. A. Franklin;R. A. Larson;T. W. Mckeithan

  • Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma

    Tayla B. Heavican;Alyssa Bouska;Jiayu Yu;Waseem Lone

  • Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma.

    Javeed Iqbal;Timothy Charles Greiner;K. Patel;Bhavana J Dave

  • IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma

    Chao Wang;Chao Wang;Chao Wang;Timothy W. McKeithan;Qiang Gong;Weiwei Zhang

  • The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation

    E. Rao;C. Jiang;M. Ji;X. Huang

  • BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study.

    Timothy W. McKeithan;Glenn S. Takimoto;Hitoshi Ohno;Vincent S. Bjorling

  • Quantitative Proteomics Reveals that miR-155 Regulates the PI3K-AKT Pathway in Diffuse Large B-Cell Lymphoma

    Xin Huang;Yulei Shen;Miao Liu;Chengfeng Bi

  • Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites.

    F V Rassool;T W McKeithan;M E Neilly;E van Melle

  • Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia

    E A Shima;M M Le Beau;T W McKeithan;J Minowada

  • Clinical, morphologic, and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11).

    Maya Thangavelu;Olufunmilayo Olopade;Enrique Beckman;James W. Vardiman

  • Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia.

    Timothy W. McKeithan;Janet D. Rowley;Thomas B. Shows;Manuel O. Diaz

  • The proto-oncogene bcl-3 encodes an I kappa B protein.

    Lawrence D. Kerr;Colin S. Duckett;Penny Wamsley;Qiang Zhang

  • Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis

    Giuseppina Nucifora;Debra J. Birn;Rafael Espinosa;Paul Erickson

  • Genome-wide copy-number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma

    Alyssa Bouska;Timothy W. McKeithan;Karen E. Deffenbacher;Cynthia Lachel

Frequent Co-Authors

Janet D. Rowley
Janet D. Rowley University of Chicago
Michelle M. Le Beau
Michelle M. Le Beau University of Chicago
Manuel O. Diaz
Manuel O. Diaz Loyola University Chicago
Richard A. Larson
Richard A. Larson University of Chicago
Alex MacKenzie
Alex MacKenzie Children's Hospital of Eastern Ontario
Robert G. Korneluk
Robert G. Korneluk University of Ottawa
Harry A. Drabkin
Harry A. Drabkin Medical University of South Carolina
James W. Vardiman
James W. Vardiman University of Chicago
Thomas W. Glover
Thomas W. Glover University of Michigan–Ann Arbor
david i smith
david i smith Mayo Clinic

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