david i smith

What is he best known for?

The fields of study he is best known for:

• Gene
• DNA
• Cancer

His primary scientific interests are in Cancer research, Genetics, Chromosomal fragile site, Carcinogenesis and Gene. His studies deal with areas such as Mutation, Transfection, Lymphoma, Tumor suppressor gene and Virus Integration as well as Cancer research. His studies in Tumor suppressor gene integrate themes in fields like Lung cancer, AXIN2, Colorectal cancer and Exon.

His Chromosomal fragile site research includes themes of Fluorescence in situ hybridization, Aphidicolin, Cervical cancer and Genome instability. His work deals with themes such as Molecular biology and Virology, which intersect with Carcinogenesis. The study incorporates disciplines such as Bladder cancer and Urinary bladder in addition to Molecular biology.

His most cited work include:

• Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling. (431 citations)
• Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss (270 citations)
• A role for common fragile site induction in amplification of human oncogenes. (251 citations)

What are the main themes of his work throughout his whole career to date?

David I. Smith spends much of his time researching Genetics, Cancer research, Gene, Chromosomal fragile site and Molecular biology. His Cancer research research includes elements of Carcinogenesis, Cancer, Tumor suppressor gene, Cell and Mutation. His Cancer research is multidisciplinary, relying on both Carcinoma, Pathology and Oncology.

His Chromosomal fragile site study also includes fields such as

• FHIT which intersects with area such as WWOX,
• Fluorescence in situ hybridization which intersects with area such as Bacterial artificial chromosome. He interconnects Translocation Breakpoint, Messenger RNA and Gene mapping in the investigation of issues within Molecular biology. His study looks at the relationship between Loss of heterozygosity and topics such as Ovarian cancer, which overlap with Ovary.

He most often published in these fields:

• Genetics (40.96%)
• Cancer research (40.43%)
• Gene (36.17%)

What were the highlights of his more recent work (between 2009-2020)?

• Genetics (40.96%)
• Cancer research (40.43%)
• Gene (36.17%)

In recent papers he was focusing on the following fields of study:

His main research concerns Genetics, Cancer research, Gene, Cancer and DNA sequencing. His studies deal with areas such as Cell, Gene expression profiling, Transcriptome, microRNA and Lymphoma as well as Cancer research. His study on Chromosomal fragile site, RNA, Sequence analysis and Fusion gene is often connected to TP63 as part of broader study in Gene.

His Cancer study integrates concerns from other disciplines, such as Oncology and Untranslated region. His studies in DNA sequencing integrate themes in fields like Genome, Human genome, Genomics and Computational biology. His Human genome research is multidisciplinary, incorporating elements of Cervical cancer, Whole genome sequencing and Molecular biology.

Between 2009 and 2020, his most popular works were:

• Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss (270 citations)
• Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing. (198 citations)
• Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas (145 citations)

In his most recent research, the most cited papers focused on:

• Gene
• DNA
• Cancer

David I. Smith mainly investigates Genetics, Gene, Cancer research, Chromosomal fragile site and Exome sequencing. His research combines Cervical adenocarcinoma and Gene. David I. Smith combines subjects such as Gene expression profiling, Cervical cancer, Lymphoma, Pathology and microRNA with his study of Cancer research.

He works on Chromosomal fragile site which deals in particular with Chromosome Fragile Site. David I. Smith has included themes like Hereditary sensory and autonomic neuropathy, Cell cycle phase, DNA mismatch repair and Hereditary motor and sensory neuropathy in his Exome sequencing study. The concepts of his RNA study are interwoven with issues in Molecular biology and Gene knockdown.